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Details

Stereochemistry RACEMIC
Molecular Formula C21H23NO3.BrH
Molecular Weight 418.324
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROROXAN HYDROBROMIDE

SMILES

Br.O=C(CCN1CCC(C1)C2=CC=CC=C2)C3=CC=C4OCCOC4=C3

InChI

InChIKey=YRTLMJNPRCWOML-UHFFFAOYSA-N
InChI=1S/C21H23NO3.BrH/c23-19(17-6-7-20-21(14-17)25-13-12-24-20)9-11-22-10-8-18(15-22)16-4-2-1-3-5-16;/h1-7,14,18H,8-13,15H2;1H

HIDE SMILES / InChI

Molecular Formula C21H23NO3
Molecular Weight 337.4122
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula BrH
Molecular Weight 80.912
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Proroxan is a non-selective а-adrenoblocker. Proroxan was found to prevent the development of hypertensive crises and improve cerebral bioelectrical parameters in most of hypertensive patients. Proroxan has been used as an antihypertensive and in the treatment of Ménière’s disease, motion sickness, and allergic dermatitis.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Pirroksan
Primary
Pirroksan
Primary
Pirroksan

OverviewOther

Other InhibitorOther SubstrateOther Inducer



Drug as perpetrator​

Drug as victim

Tox targets

PubMed

Sample Use Guides

In Vivo Use Guide
Adults: tablets - 20 mg 2-3 times a day; injection - 2-3 ml per day; The maximum daily dose is 90 mg;
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
J48JGW5NHZ
Record Status Validated (UNII)
Record Version