PROROXAN HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H23NO3.ClH
Molecular Weight	373.873
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.O=C(CCN1CCC(C1)C2=CC=CC=C2)C3=CC4=C(OCCO4)C=C3

InChI

InChIKey=QQZPGRDQMBPRFY-UHFFFAOYSA-N

InChI=1S/C21H23NO3.ClH/c23-19(17-6-7-20-21(14-17)25-13-12-24-20)9-11-22-10-8-18(15-22)16-4-2-1-3-5-16;/h1-7,14,18H,8-13,15H2;1H

HIDE SMILES / InChI

Molecular Formula	C21H23NO3
Molecular Weight	337.4122
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://paper.rsmu.ru/pirogovka_2015/articles/article.php?thesis_number=90 | https://www.ncbi.nlm.nih.gov/pubmed/26087584 | http://noillen.bitballoon.com/medicine2/pirroksan-instructio1832

Proroxan is a non-selective а-adrenoblocker. Proroxan was found to prevent the development of hypertensive crises and improve cerebral bioelectrical parameters in most of hypertensive patients. Proroxan has been used as an antihypertensive and in the treatment of Ménière’s disease, motion sickness, and allergic dermatitis.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor alpha-1 169 Target ID: CHEMBL2094251 Sources: http://paper.rsmu.ru/pirogovka_2015/articles/article.php?thesis_number=90 \| https://www.ncbi.nlm.nih.gov/pubmed/26087584 \| http://dspace.vnmu.edu.ua/bitstream/handle/123456789/1660/General_Pharmacology%20and%20drugs%20affecting%20mediatory%20processes.pdf?sequence=1 \| http://medsideen.bitballoon.com/for-the-nervous-syst102/pirroksan2432.html	Antagonist 2778
Adrenergic receptor alpha-2 113 Target ID: CHEMBL2095158 Sources: http://paper.rsmu.ru/pirogovka_2015/articles/article.php?thesis_number=90 \| https://www.ncbi.nlm.nih.gov/pubmed/26087584 \| http://dspace.vnmu.edu.ua/bitstream/handle/123456789/1660/General_Pharmacology%20and%20drugs%20affecting%20mediatory%20processes.pdf?sequence=1 \| http://medsideen.bitballoon.com/for-the-nervous-syst102/pirroksan2432.html	Antagonist 2778

Conditions

Condition	Modality	Highest Phase	Product
Hypertension 567 Sources: http://drdoping.com/instructions/Proroxan/ http://dspace.vnmu.edu.ua/bitstream/handle/123456789/1660/General_Pharmacology%20and%20drugs%20affecting%20mediatory%20processes.pdf?sequence=1	Primary	Approved 8429	Pirroksan Approved Use Proroxan has been used as an antihypertensive and in the treatment of Ménière’s disease, motion sickness, and allergic dermatitis.
Meniere's disease 16 Sources: http://drdoping.com/instructions/Proroxan/ http://medsideen.bitballoon.com/for-the-nervous-syst102/pirroksan2432.html	Primary	Approved 8429	Pirroksan Approved Use Proroxan has been used as an antihypertensive and in the treatment of Ménière’s disease, motion sickness, and allergic dermatitis.
Motion sickness 43 Sources: http://noillen.bitballoon.com/medicine2/pirroksan-instructio1832 http://medsideen.bitballoon.com/for-the-nervous-syst102/pirroksan2432.html	Primary	Approved 8429	Pirroksan Approved Use Proroxan has been used as an antihypertensive and in the treatment of Ménière’s disease, motion sickness, and allergic dermatitis.

PubMed

Title	Date	PubMed
[Adrenergic component in the hepatotropic, carcinogenic effect of diethylnitrosamine].	1977 Apr	15687

Patents

Sample Use Guides

In Vivo Use Guide

Adults: tablets - 20 mg 2-3 times a day; injection - 2-3 ml per day; The maximum daily dose is 90 mg;

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:48:11 GMT 2023` Edited by `admin` on `Fri Dec 15 15:48:11 GMT 2023`
Record UNII	694Z9P44G4
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PROROXAN HYDROCHLORIDE

Official Name

English

PIROXAN

Brand Name

English

1-(1,4-Benzodioxan-6-yl)-3-(3-phenyl-1-pyrrolidinyl)-1-propanone hydrochloride

Systematic Name

English

AY-24,269

Code

English

PROROXAN HYDROCHLORIDE [USAN]

Common Name

English

1-PROPANONE, 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-(3-PHENYL-1-PYRROLIDINYL)-, HYDROCHLORIDE

Systematic Name

English

AY-24269

Code

English

PYRROXAN

Brand Name

English

PROROXAN HCL

Common Name

English

PROROXAN HYDROCHLORIDE [MART.]

Common Name

English

Proroxan hydrochloride [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29713