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Ensereptide (PXL01) is a polypeptide derived from human lactoferrin. PXL01 has several mechanisms of action; including immunomodulation and enhancement of fibrinolytic activity. PXL01 produces its immunomodulatory action by inhibiting the release of pro-inflammatory cytokines, such as IL-1β, IL-6 and Il-8 as well as TNF- α (tumor necrosis factor alpha). PXL01 also inhibits the local production of PAI-1 which is an important mediator of fibrinolysis. The anti-inflammatory properties combined with the modulation of fibrinolysis are assumed to account for the ability of the product candidate to prevent post-surgical adhesions and scar formation. Ensereptide (PXL01) is being developed by ProMore Pharma for the treatment of post-surgical adhesions and for prevention of dermal scarring after surgery or trauma.

Approval Year

PubMed

PubMed

TitleDatePubMed
Effect of major abdominal surgery on the host immune response to infection.
2010 Jun
Effect of lactoferrin peptide (PXL01) on rabbit digit mobility after flexor tendon repair.
2012 Dec
Patents

Patents

Sample Use Guides

20 mg/ml of PXL01 and 15 mg/ml of sodium hyaluronate. 0.5 ml of the mixed product was administered in the surgical area in flexor tendon repair surgery, corresponding to a dose of 10 mg PXL01.
Route of Administration: Topical
Substance Class Protein
Created
by admin
on Sat Dec 16 09:09:02 GMT 2023
Edited
by admin
on Sat Dec 16 09:09:02 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
SMV73KW49C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ENSEREPTIDE
INN  
INN  
Official Name English
PXL01
Code English
PXL-01
Code English
ACETYL(HUMAN LACTOTRANSFERRIN-(15-39)-PEPTIDAMIDE)
Common Name English
ensereptide [INN]
Common Name English
Code System Code Type Description
NCI_THESAURUS
C169952
Created by admin on Sat Dec 16 09:09:02 GMT 2023 , Edited by admin on Sat Dec 16 09:09:02 GMT 2023
PRIMARY
FDA UNII
SMV73KW49C
Created by admin on Sat Dec 16 09:09:02 GMT 2023 , Edited by admin on Sat Dec 16 09:09:02 GMT 2023
PRIMARY
PUBCHEM
49863418
Created by admin on Sat Dec 16 09:09:02 GMT 2023 , Edited by admin on Sat Dec 16 09:09:02 GMT 2023
PRIMARY
CAS
254433-51-7
Created by admin on Sat Dec 16 09:09:02 GMT 2023 , Edited by admin on Sat Dec 16 09:09:02 GMT 2023
PRIMARY
INN
9579
Created by admin on Sat Dec 16 09:09:02 GMT 2023 , Edited by admin on Sat Dec 16 09:09:02 GMT 2023
PRIMARY
From To
1_5 1_22
Related Record Type Details
TARGET->INHIBITOR OF EXPRESSION
TARGET->INHIBITOR OF EXPRESSION
TARGET->ACTIVATOR OF EXPRESSION
Increased expression of PRG4 mRNA in tendons treated with rabPXL01 in HA, but not in tendon sheaths. In addition, treatment with rabPXL01 in HA led to repression of the mRNA levels for the pro-inflammatory mediators interleukin (IL)-1β, IL-6, and IL-8 in tendon sheaths.
TARGET->INHIBITOR OF EXPRESSION
Increased expression of PRG4 mRNA in tendons treated with rabPXL01 in HA, but not in tendon sheaths. In addition, treatment with rabPXL01 in HA led to repression of the mRNA levels for the pro-inflammatory mediators interleukin (IL)-1β, IL-6, and IL-8 in tendon sheaths.
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL