Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C7H11NO5 |
| Molecular Weight | 189.1659 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI
InChIKey=RFMMMVDNIPUKGG-YFKPBYRVSA-N
InChI=1S/C7H11NO5/c1-4(9)8-5(7(12)13)2-3-6(10)11/h5H,2-3H2,1H3,(H,8,9)(H,10,11)(H,12,13)/t5-/m0/s1
| Molecular Formula | C7H11NO5 |
| Molecular Weight | 189.1659 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| N-acetyl-glutamate synthetase deficiency or porto-systemic shunt associated encephalopathy? | 2002 |
|
| Hyperammonemia in carnitine-deficient adult JVS mice used by starvation. | 2002 Dec |
|
| N-acetylglutamate synthase deficiency and the treatment of hyperammonemic encephalopathy. | 2002 Dec |
|
| Regulation of urea synthesis by agmatine in the perfused liver: studies with 15N. | 2002 Dec |
|
| Cloning and expression of the human N-acetylglutamate synthase gene. | 2002 Dec 13 |
|
| Role of N-acetylglutamate concentration and ornithine transport into mitochondria in urea synthesis of rats given proteins of different quality. | 2002 Dec 4 |
|
| Hepatic glutaminase--a special role in urea synthesis? | 2002 Jun |
|
| Towards structural understanding of feedback control of arginine biosynthesis: cloning and expression of the gene for the arginine-inhibited N-acetyl-L-glutamate kinase from Pseudomonas aeruginosa, purification and crystallization of the recombinant enzyme and preliminary X-ray studies. | 2002 Jun |
|
| Identification, cloning and expression of the mouse N-acetylglutamate synthase gene. | 2002 Jun 15 |
|
| Structure of acetylglutamate kinase, a key enzyme for arginine biosynthesis and a prototype for the amino acid kinase enzyme family, during catalysis. | 2002 Mar |
|
| A crystallographic glimpse of a nucleotide triphosphate (AMPPNP) bound to a protein surface: external and internal AMPPNP molecules in crystalline N-acetyl-L-glutamate kinase. | 2002 Oct |
|
| Enantioseparation of amino acid derivatives by capillary zone electrophoresis using vancomycin as chiral selector. | 2002 Sep |
|
| A radiometric assay for aspartoacylase activity in cultured oligodendrocytes. | 2002 Sep 15 |
|
| Null mutations in the N-acetylglutamate synthase gene associated with acute neonatal disease and hyperammonemia. | 2003 Apr |
|
| Mutation analysis in patients with N-acetylglutamate synthase deficiency. | 2003 Jun |
|
| N-acetylglutamate and its changing role through evolution. | 2003 Jun 1 |
|
| The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis. | 2003 Mar |
|
| Straightforward relative quantitation and age-related human standards of N-acetylaspartate at the centrum semiovale level by CSI (1)H-MRS. | 2003 Nov |
|
| Complex formation and catalytic activation by the PII signaling protein of N-acetyl-L-glutamate kinase from Synechococcus elongatus strain PCC 7942. | 2004 Dec 31 |
|
| Carglumic acid: new preparation. An advance in rare urea cycle disorders. | 2004 Feb |
|
| Urea synthesis by ruminal epithelial and duodenal mucosal cells from growing sheep. | 2004 Jun |
|
| The Synechococcus elongatus P signal transduction protein controls arginine synthesis by complex formation with N-acetyl-L-glutamate kinase. | 2004 Jun |
|
| N-carbamylglutamate protects patients with decompensated propionic aciduria from hyperammonaemia. | 2005 |
|
| Role of N-acetylglutamate turnover in urea synthesis of rats given proteins of different quality. | 2005 Apr |
|
| Identification of novel mutations of the human N-acetylglutamate synthase gene and their functional investigation by expression studies. | 2005 Apr 15 |
|
| Increases in urea synthesis and the ornithine-urea cycle capacity in the giant African snail, Achatina fulica, during fasting or aestivation, or after the injection with ammonium chloride. | 2005 Dec 1 |
|
| Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles. | 2005 Mar |
|
| Unusual reactivity in a commercial chromium supplement compared to baseline DNA cleavage with synthetic chromium complexes. | 2005 Mar |
|
| A comprehensive update of the sequence and structure classification of kinases. | 2005 Mar 16 |
|
| The little skate Raja erinacea exhibits an extrahepatic ornithine urea cycle in the muscle and modulates nitrogen metabolism during low-salinity challenge. | 2005 Mar-Apr |
|
| Understanding carbamoyl phosphate synthetase deficiency: impact of clinical mutations on enzyme functionality. | 2005 May 27 |
|
| The role of mitochondrially bound arginase in the regulation of urea synthesis: studies with [U-15N4]arginine, isolated mitochondria, and perfused rat liver. | 2005 May 6 |
|
| The regulatory PII protein controls arginine biosynthesis in Arabidopsis. | 2006 Apr 3 |
|
| Tight binding inhibitors of N-acyl amino sugar and N-acyl amino acid deacetylases. | 2006 Apr 5 |
|
| Expression, crystallization and preliminary crystallographic studies of a novel bifunctional N-acetylglutamate synthase/kinase from Xanthomonas campestris homologous to vertebrate N-acetylglutamate synthase. | 2006 Dec 1 |
|
| [Cloning, sequence analysis and expression of N-acetylglutamate kinase gene in Corynebacterium crenatum]. | 2006 Feb |
|
| Expression of ornithine-urea cycle enzymes in early life stages of air-breathing walking catfish Clarias batrachus and induction of ureogenesis under hyper-ammonia stress. | 2006 Jan |
|
| Bioinformatic analysis of an unusual gene-enzyme relationship in the arginine biosynthetic pathway among marine gamma proteobacteria: implications concerning the formation of N-acetylated intermediates in prokaryotes. | 2006 Jan 12 |
|
| The dogfish shark (Squalus acanthias) increases both hepatic and extrahepatic ornithine urea cycle enzyme activities for nitrogen conservation after feeding. | 2006 May-Jun |
|
| A metabonomics study of the hepatotoxicants galactosamine, methylene dianiline and clofibrate in rats. | 2006 Sep |
|
| Polar body-based preimplantation genetic diagnosis for N-acetylglutamate synthase deficiency. | 2008 |
|
| Protein preparation, crystallization and preliminary X-ray crystallographic analysis of N-acetylglutamate kinase from Streptococcus mutans. | 2008 |
|
| Identification and characterization of a plastid-localized Arabidopsis glyoxylate reductase isoform: comparison with a cytosolic isoform and implications for cellular redox homeostasis and aldehyde detoxification. | 2008 |
|
| Ornithine-delta-aminotransferase is essential for arginine catabolism but not for proline biosynthesis. | 2008 Apr 17 |
|
| Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. | 2008 Apr 25 |
|
| Human carbamoyl-phosphate synthetase: insight into N-acetylglutamate interaction and the functional effects of a common single nucleotide polymorphism. | 2008 Aug |
|
| Horizontal gene transfers link a human MRSA pathogen to contagious bovine mastitis bacteria. | 2008 Aug 27 |
|
| Novel suppressors of alpha-synuclein toxicity identified using yeast. | 2008 Dec 1 |
|
| Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis. | 2008 Oct 17 |
|
| 'Naked-eye' enantioselective chemosensors for N-protected amino acid anions bearing thiourea units. | 2009 Mar |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:30:16 GMT 2025
by
admin
on
Mon Mar 31 20:30:16 GMT 2025
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| Record UNII |
MA61H539YZ
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| Record Status |
Validated (UNII)
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70914
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2001205
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DB04075
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N-ACETYLGLUTAMIC ACID
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17533
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MA61H539YZ
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DTXSID3046534
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1188-37-0
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214-708-4
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MA61H539YZ
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