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Details

Stereochemistry ACHIRAL
Molecular Formula C28H41ClN2O
Molecular Weight 457.091
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TEROXALENE

SMILES

CCC(C)(C)C1=CC=C(OCCCCCCN2CCN(CC2)C3=CC(Cl)=C(C)C=C3)C=C1

InChI

InChIKey=LRQIJOWDNRNLDY-UHFFFAOYSA-N
InChI=1S/C28H41ClN2O/c1-5-28(3,4)24-11-14-26(15-12-24)32-21-9-7-6-8-16-30-17-19-31(20-18-30)25-13-10-23(2)27(29)22-25/h10-15,22H,5-9,16-21H2,1-4H3

HIDE SMILES / InChI
Molecular Formula C28H41ClN2O
Molecular Weight 457.091
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Teroxalene is a dioxopiperazine derivative with multidrug resistance reversal activity

Originator

Michalsky, Jiri; Ctvrtnik, Josef
2
Sources: CS106503 "Derivatives of 2,​5-​dioxopiperazine" Feb 15, 1963

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Reversal of multidrug resistance by bis(phenylalkyl)amines and structurally related compounds.
1994
Patents

Patents

20040058896
57
6331289
128
6680047
81
CS106503
2
WO2007061529A1
72
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:18:11 GMT 2023
Edited
by admin
on Fri Dec 15 18:18:11 GMT 2023
Record UNII
R4ZID09918
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TEROXALENE
INN  
INN  
Official Name English
1-(3-CHLORO-P-TOLYL)-4-(6-(P-TERT-PENTYLPHENOXY)HEXYL)PIPERAZINE
Common Name English
teroxalene [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C250
Created by admin on Fri Dec 15 18:18:11 GMT 2023 , Edited by admin on Fri Dec 15 18:18:11 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID40163643
Created by admin on Fri Dec 15 18:18:11 GMT 2023 , Edited by admin on Fri Dec 15 18:18:11 GMT 2023
PRIMARY
PUBCHEM
19705
Created by admin on Fri Dec 15 18:18:11 GMT 2023 , Edited by admin on Fri Dec 15 18:18:11 GMT 2023
PRIMARY
FDA UNII
R4ZID09918
Created by admin on Fri Dec 15 18:18:11 GMT 2023 , Edited by admin on Fri Dec 15 18:18:11 GMT 2023
PRIMARY
INN
2170
Created by admin on Fri Dec 15 18:18:11 GMT 2023 , Edited by admin on Fri Dec 15 18:18:11 GMT 2023
PRIMARY
SMS_ID
100000082713
Created by admin on Fri Dec 15 18:18:11 GMT 2023 , Edited by admin on Fri Dec 15 18:18:11 GMT 2023
PRIMARY
NCI_THESAURUS
C152571
Created by admin on Fri Dec 15 18:18:11 GMT 2023 , Edited by admin on Fri Dec 15 18:18:11 GMT 2023
PRIMARY
ChEMBL
CHEMBL2111143
Created by admin on Fri Dec 15 18:18:11 GMT 2023 , Edited by admin on Fri Dec 15 18:18:11 GMT 2023
PRIMARY
CAS
14728-33-7
Created by admin on Fri Dec 15 18:18:11 GMT 2023 , Edited by admin on Fri Dec 15 18:18:11 GMT 2023
PRIMARY
EVMPD
SUB10931MIG
Created by admin on Fri Dec 15 18:18:11 GMT 2023 , Edited by admin on Fri Dec 15 18:18:11 GMT 2023
PRIMARY
Related Record Type Details
Structure of TEROXALENE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of TEROXALENE
ACTIVE MOIETY
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