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Details

Stereochemistry ACHIRAL
Molecular Formula C19H16F2N8O2
Molecular Weight 426.3795
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VERICIGUAT

SMILES

COC(=O)NC1=C(N)N=C(N=C1N)C2=NN(CC3=CC=CC=C3F)C4=NC=C(F)C=C24

InChI

InChIKey=QZFHIXARHDBPBY-UHFFFAOYSA-N
InChI=1S/C19H16F2N8O2/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27)

HIDE SMILES / InChI

Molecular Formula C19H16F2N8O2
Molecular Weight 426.3795
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Vericiguat, discovered at Bayer, is the first soluble guanylate cyclase (sGC) stimulator. Vericiguat is currently being studied in a Phase III clinical program for the treatment of heart failure with reduced ejection fraction (HFrEF).

Originator

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
1005.0 nM [EC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PubMed

PubMed

TitleDatePubMed
Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure.
2017 Jun 22
Patents

Sample Use Guides

In Vivo Use Guide
Starting dose of 2.5 mg taken orally once daily with food, on a background of standard of care. Dose will be uptitrated to 5 mg and to 10 mg.
Route of Administration: Oral
In Vitro Use Guide
Studies on the in vitro effects of Vericiguat on highly purified sGC (soluble guanylate cyclase) revealed that Vericiguat (0.01 uM to 100 uM) stimulates recombinant sGC concentration dependently, by 1.7-fold to 57.6-fold.
Substance Class Chemical
Created
by admin
on Mon Oct 21 20:25:23 UTC 2019
Edited
by admin
on Mon Oct 21 20:25:23 UTC 2019
Record UNII
LV66ADM269
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VERICIGUAT
INN  
USAN   INN  
Official Name English
METHYL N-(4,6-DIAMINO-2-(5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO(3,4-B)PYRIDIN-3-YL)PYRIMIDIN-5-YL)CARBAMATE
Systematic Name English
VERICIGUAT [INN]
Common Name English
METHYL (4,6-DIAMINO-2-(5-FLUORO-1-((2-FLUOROPHENYL)METHYL)-1H-PYRAZOLO(3,4-B)PYRIDIN-3-YL(PYRIMIDIN-5-YL)CARBAMATE
Systematic Name English
METHYL (4,6-DIAMINO-2-(5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO(3,4-B)PYRIDIN-3-YL)PYRIMIDIN-5-YL)CARBAMATE
Systematic Name English
BAY-1021189
Code English
VERICIGUAT [WHO-DD]
Common Name English
MK-1242
Code English
VERICIGUAT [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29707
Created by admin on Mon Oct 21 20:25:23 UTC 2019 , Edited by admin on Mon Oct 21 20:25:23 UTC 2019
Code System Code Type Description
INN
9805
Created by admin on Mon Oct 21 20:25:23 UTC 2019 , Edited by admin on Mon Oct 21 20:25:23 UTC 2019
PRIMARY
NCI_THESAURUS
C152862
Created by admin on Mon Oct 21 20:25:23 UTC 2019 , Edited by admin on Mon Oct 21 20:25:23 UTC 2019
PRIMARY
CAS
1350653-20-1
Created by admin on Mon Oct 21 20:25:23 UTC 2019 , Edited by admin on Mon Oct 21 20:25:23 UTC 2019
PRIMARY
PUBCHEM
54674461
Created by admin on Mon Oct 21 20:25:23 UTC 2019 , Edited by admin on Mon Oct 21 20:25:23 UTC 2019
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY