Details
Stereochemistry | ACHIRAL |
Molecular Formula | C19H16F2N8O2.ClH |
Molecular Weight | 462.8412 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(=Nc1c(=N)[nH]c(-c2c3cc(cnc3n(Cc4ccccc4F)n2)F)nc1N)O.Cl
InChI
InChIKey=MEOLGPNZHXRKRG-UHFFFAOYSA-N
InChI=1S/C19H16F2N8O2.ClH/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21;/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27);1H
Molecular Formula | ClH |
Molecular Weight | 36.4609 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C19H16F2N8O2 |
Molecular Weight | 426.3803 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2111348 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28557445 |
1005.0 nM [EC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT02861534
Starting dose of 2.5 mg taken orally once daily with food, on a background of standard of care. Dose will be uptitrated to 5 mg and to 10 mg.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28557445
Studies on the in
vitro effects of Vericiguat on highly purified sGC (soluble guanylate cyclase) revealed that Vericiguat (0.01
uM to 100 uM) stimulates recombinant sGC concentration
dependently, by 1.7-fold to 57.6-fold.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 08:20:04 UTC 2021
by
admin
on
Sat Jun 26 08:20:04 UTC 2021
|
Record UNII |
5G76IGF54K
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
5G76IGF54K
Created by
admin on Sat Jun 26 08:20:04 UTC 2021 , Edited by admin on Sat Jun 26 08:20:04 UTC 2021
|
PRIMARY | |||
|
1350658-96-6
Created by
admin on Sat Jun 26 08:20:04 UTC 2021 , Edited by admin on Sat Jun 26 08:20:04 UTC 2021
|
PRIMARY | |||
|
SUB185342
Created by
admin on Sat Jun 26 08:20:04 UTC 2021 , Edited by admin on Sat Jun 26 08:20:04 UTC 2021
|
PRIMARY | |||
|
72942024
Created by
admin on Sat Jun 26 08:20:04 UTC 2021 , Edited by admin on Sat Jun 26 08:20:04 UTC 2021
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |