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Details

Stereochemistry ACHIRAL
Molecular Formula C19H16F2N8O2.ClH
Molecular Weight 462.84
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VERICIGUAT HYDROCHLORIDE

SMILES

Cl.COC(=O)NC1=C(N)N=C(N=C1N)C2=NN(CC3=CC=CC=C3F)C4=NC=C(F)C=C24

InChI

InChIKey=MEOLGPNZHXRKRG-UHFFFAOYSA-N
InChI=1S/C19H16F2N8O2.ClH/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21;/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27);1H

HIDE SMILES / InChI

Molecular Formula C19H16F2N8O2
Molecular Weight 426.3795
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Vericiguat, discovered at Bayer, is the first soluble guanylate cyclase (sGC) stimulator. Vericiguat is currently being studied in a Phase III clinical program for the treatment of heart failure with reduced ejection fraction (HFrEF).

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
1005.0 nM [EC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

Starting dose of 2.5 mg taken orally once daily with food, on a background of standard of care. Dose will be uptitrated to 5 mg and to 10 mg.
Route of Administration: Oral
Studies on the in vitro effects of Vericiguat on highly purified sGC (soluble guanylate cyclase) revealed that Vericiguat (0.01 uM to 100 uM) stimulates recombinant sGC concentration dependently, by 1.7-fold to 57.6-fold.
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:00:34 GMT 2023
Edited
by admin
on Sat Dec 16 08:00:34 GMT 2023
Record UNII
5G76IGF54K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VERICIGUAT HYDROCHLORIDE
Common Name English
METHYL (4,6-DIAMINO-2-(5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO(3,4-B)PYRIDIN-3-YL)PYRIMIDIN-5-YL)CARBAMATE HYDROCHLORIDE
Systematic Name English
Vericiguat hydrochloride [WHO-DD]
Common Name English
CARBAMIC ACID, N-(4,6-DIAMINO-2-(5-FLUORO-1-((2-FLUOROPHENYL)METHYL)-1H-PYRAZOLO(3,4-B)PYRIDIN-3-YL)-5-PYRIMIDINYL)-, METHYL ESTER, HYDROCHLORIDE (1:1)
Common Name English
Code System Code Type Description
FDA UNII
5G76IGF54K
Created by admin on Sat Dec 16 08:00:34 GMT 2023 , Edited by admin on Sat Dec 16 08:00:34 GMT 2023
PRIMARY
CAS
1350658-96-6
Created by admin on Sat Dec 16 08:00:34 GMT 2023 , Edited by admin on Sat Dec 16 08:00:34 GMT 2023
PRIMARY
EVMPD
SUB185342
Created by admin on Sat Dec 16 08:00:34 GMT 2023 , Edited by admin on Sat Dec 16 08:00:34 GMT 2023
PRIMARY
SMS_ID
100000171734
Created by admin on Sat Dec 16 08:00:34 GMT 2023 , Edited by admin on Sat Dec 16 08:00:34 GMT 2023
PRIMARY
PUBCHEM
72942024
Created by admin on Sat Dec 16 08:00:34 GMT 2023 , Edited by admin on Sat Dec 16 08:00:34 GMT 2023
PRIMARY
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