U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H7Cl2N3O
Molecular Weight 256.088
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ANAGRELIDE

SMILES

ClC1=CC=C2NC3=NC(=O)CN3CC2=C1Cl

InChI

InChIKey=OTBXOEAOVRKTNQ-UHFFFAOYSA-N
InChI=1S/C10H7Cl2N3O/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7/h1-2H,3-4H2,(H,13,14,16)

HIDE SMILES / InChI
Molecular Formula C10H7Cl2N3O
Molecular Weight 256.088
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: http://www.rxlist.com/agrylin-drug.htm | https://www.drugs.com/pro/anagrelide.html | https://www.ncbi.nlm.nih.gov/pubmed/20331456

Anagrelide is an orally active quinazinolone derivative that was originally developed as an antiplatelet drug. The drug inhibits cyclic nucleotide phosphodiesterase III (PDEIII) and phopholipase A2, which is thought to cause the side effects of vasodilation, positive inotropism, reduced platelet aggregation. However, significant inhibition of platelet aggregation is observed only at doses of anagrelide higher than those required to reduce platelet count. It is indicated for the treatment of patients with thrombocythemia, secondary to myeloproliferative disorders. Commonly reported side effects of anagrelide include: abdominal pain, dizziness, headache, nausea, and palpitations. Other side effects include: back pain, fever, tachycardia, vomiting, and anorexia. There is a single case report, which suggests that sucralfate may interfere with anagrelide absorption. Anagrelide is an inhibitor of cyclic AMP PDE III. The effects of medicinal products with similar properties such as inotropes milrinone, enoximone, amrinone, olprinone and cilostazol may be exacerbated by anagrelide.

Originator

Approval Year

1997
172
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 36.0 nM [IC50]
Inhibitor
8297
Cytochrome P450 1A2
72
Target ID: P05177
Gene ID: 1544.0
Gene Symbol: CYP1A2
Target Organism: Homo sapiens (Human)
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
AGRYLIN

Approved Use

Anagrelide hydrochloride capsules are indicated for the treatment of patients with thrombocythemia, secondary to myeloproliferative disorders, to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms including thrombo-hemorrhagic events (see CLINICAL STUDIES, DOSAGE AND ADMINISTRATION).

Launch Date

1997
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
10.28 ng/mL
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/19302911
2 mg single, oral
dose: 2 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ANAGRELIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
28.39 ng × h/mL
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/19302911
2 mg single, oral
dose: 2 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ANAGRELIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
1.38 h
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/19302911
2 mg single, oral
dose: 2 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ANAGRELIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
1.9 mg 1 times / day multiple, oral (mean)
Recommended
Dose: 1.9 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1.9 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
unhealthy, 58
n = 16
Health Status: unhealthy
Condition: Thrombocythemia
Age Group: 58
Sex: M+F
Population Size: 16
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
Disc. AE: Dizziness postural, Palpitations...
AEs leading to
discontinuation/dose reduction:
Dizziness postural (6.25%)
Palpitations (12.5%)
Chest pain (6.25%)
Sinus tachycardia (6.25%)
Abdominal pain (6.25%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
1 mg 2 times / day multiple, oral
Recommended
Dose: 1 mg, 2 times / day
Route: oral
Route: multiple
Dose: 1 mg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
unhealthy
n = 942
Health Status: unhealthy
Condition: Thrombocythemia
Population Size: 942
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
Disc. AE: Headache, Diarrhea...
AEs leading to
discontinuation/dose reduction:
Headache
Diarrhea
Edema
Palpitations
Abdominal pain
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
10 mg 1 times / day multiple, oral (total daily dose)
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Thrombocythemia
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
Disc. AE: Cardiotoxicity, QT interval prolonged...
AEs leading to
discontinuation/dose reduction:
Cardiotoxicity
QT interval prolonged
Ventricular tachycardia
Pulmonary hypertension
Bleeding
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
AEs

AEs

AESignificanceDosePopulation
Palpitations 12.5%
Disc. AE
1.9 mg 1 times / day multiple, oral (mean)
Recommended
Dose: 1.9 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1.9 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
unhealthy, 58
n = 16
Health Status: unhealthy
Condition: Thrombocythemia
Age Group: 58
Sex: M+F
Population Size: 16
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
Abdominal pain 6.25%
Disc. AE
1.9 mg 1 times / day multiple, oral (mean)
Recommended
Dose: 1.9 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1.9 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
unhealthy, 58
n = 16
Health Status: unhealthy
Condition: Thrombocythemia
Age Group: 58
Sex: M+F
Population Size: 16
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
Chest pain 6.25%
Disc. AE
1.9 mg 1 times / day multiple, oral (mean)
Recommended
Dose: 1.9 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1.9 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
unhealthy, 58
n = 16
Health Status: unhealthy
Condition: Thrombocythemia
Age Group: 58
Sex: M+F
Population Size: 16
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
Dizziness postural 6.25%
Disc. AE
1.9 mg 1 times / day multiple, oral (mean)
Recommended
Dose: 1.9 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1.9 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
unhealthy, 58
n = 16
Health Status: unhealthy
Condition: Thrombocythemia
Age Group: 58
Sex: M+F
Population Size: 16
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
Sinus tachycardia 6.25%
Disc. AE
1.9 mg 1 times / day multiple, oral (mean)
Recommended
Dose: 1.9 mg, 1 times / day
Route: oral
Route: multiple
Dose: 1.9 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
unhealthy, 58
n = 16
Health Status: unhealthy
Condition: Thrombocythemia
Age Group: 58
Sex: M+F
Population Size: 16
Sources:
https://pubmed.ncbi.nlm.nih.gov/10200810
Page: p.33
Abdominal pain Disc. AE
1 mg 2 times / day multiple, oral
Recommended
Dose: 1 mg, 2 times / day
Route: oral
Route: multiple
Dose: 1 mg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
unhealthy
n = 942
Health Status: unhealthy
Condition: Thrombocythemia
Population Size: 942
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
Diarrhea Disc. AE
1 mg 2 times / day multiple, oral
Recommended
Dose: 1 mg, 2 times / day
Route: oral
Route: multiple
Dose: 1 mg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
unhealthy
n = 942
Health Status: unhealthy
Condition: Thrombocythemia
Population Size: 942
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
Edema Disc. AE
1 mg 2 times / day multiple, oral
Recommended
Dose: 1 mg, 2 times / day
Route: oral
Route: multiple
Dose: 1 mg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
unhealthy
n = 942
Health Status: unhealthy
Condition: Thrombocythemia
Population Size: 942
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
Headache Disc. AE
1 mg 2 times / day multiple, oral
Recommended
Dose: 1 mg, 2 times / day
Route: oral
Route: multiple
Dose: 1 mg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
unhealthy
n = 942
Health Status: unhealthy
Condition: Thrombocythemia
Population Size: 942
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
Palpitations Disc. AE
1 mg 2 times / day multiple, oral
Recommended
Dose: 1 mg, 2 times / day
Route: oral
Route: multiple
Dose: 1 mg, 2 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
unhealthy
n = 942
Health Status: unhealthy
Condition: Thrombocythemia
Population Size: 942
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.4
Bleeding Disc. AE
10 mg 1 times / day multiple, oral (total daily dose)
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Thrombocythemia
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
Cardiotoxicity Disc. AE
10 mg 1 times / day multiple, oral (total daily dose)
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Thrombocythemia
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
Pulmonary hypertension Disc. AE
10 mg 1 times / day multiple, oral (total daily dose)
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Thrombocythemia
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
QT interval prolonged Disc. AE
10 mg 1 times / day multiple, oral (total daily dose)
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Thrombocythemia
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
Ventricular tachycardia Disc. AE
10 mg 1 times / day multiple, oral (total daily dose)
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Thrombocythemia
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020333s024lbl.pdf
Page: p.1
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:142290
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:142290
ChemicalBook
CB8246866
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB8246866
MolPort
MolPort-003-844-624
https://www.molport.com/shop/molecule-link/MolPort-003-844-624
MolPort
MolPort-005-934-314
https://www.molport.com/shop/molecule-link/MolPort-005-934-314
ZINC
ZINC000003871541
http://zinc15.docking.org/substances/ZINC000003871541
eMolecules
2726176
https://www.emolecules.com/cgi-bin/more?vid=2726176
eMolecules
901387
https://www.emolecules.com/cgi-bin/more?vid=901387
PubMed

PubMed

TitleDatePubMed
Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains.
1992 Jul 10
Anagrelide metabolite induces thrombocytopenia in mice by inhibiting megakaryocyte maturation without inducing platelet aggregation.
2001 Dec
Long-term use of anagrelide in young patients with essential thrombocythemia.
2001 Feb 15
Current management in polycythemia vera.
2001 Jan
Management of patients with essential thrombocythemia: current concepts and perspectives.
2001 Mar
[Treatment of essential thrombocythemia with anagrelide: a ten-year experience].
2002
What is the standard treatment in essential thrombocythemia.
2002 Aug
Therapeutic options for essential thrombocythemia and polycythemia vera.
2002 Jun
[Recurring ischemic cerebral infarction caused by primary thrombocytosis in infancy].
2003 Dec 1-15
Pilot study of pegylated interferon-alpha 2b in patients with essential thrombocythemia.
2003 Jan
Treatment of essential thrombocythemia in childhood.
2003 Jul-Aug
Efficacy and safety of long-term use of hydroxyurea in young patients with essential thrombocythemia and a high risk of thrombosis.
2003 May 1
Acute leukemia and myelodysplasia in patients with a Philadelphia chromosome negative chronic myeloproliferative disorder treated with hydroxyurea alone or with hydroxyurea after busulphan.
2003 Sep
Treatment paradigms in the management of myeloproliferative disorders.
2004 Apr
[Diagnostic and therapeutic management of essential thrombocythemia in children].
2004 Jul-Sep
Thrombocytosis.
2004 Mar 18
Essential thrombocythaemia in children: is a treatment needed?
2004 May
Essential thrombocythemia-related acute ST-segment elevation myocardial infarction. A case report and literature review.
2004 May-Jun
Anagrelide-associated cardiomyopathy in polycythemia vera and essential thrombocythemia.
2004 Nov
[Unclear liver fibrosis in a 42-year-old patient with polycythemia vera].
2004 Nov
[Retrospective analysis of the clinical course of 12 children given the diagnosis essential thrombocythemia].
2004 Nov-Dec
Anagrelide treatment in 52 patients with chronic myeloproliferative diseases.
2004 Oct
Effects of anagrelide on platelet factor 4 and vascular endothelial growth factor levels in patients with essential thrombocythemia.
2004 Sep
Primary and secondary thrombocytosis in childhood.
2005 Apr
High-output heart failure associated with anagrelide therapy for essential thrombocytosis.
2005 Aug 16
High-performance liquid chromatography-mass spectrometry method for determination of anagrelide in human plasma.
2005 Aug 5
Myeloproliferative disorders.
2005 Jul-Aug
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
Management of patients with polycythaemia vera: results of a survey among Swedish haematologists.
2005 Jun
Treatment of symptomatic patients with essential thrombocythemia: effectiveness of anagrelide.
2005 Sep
Risk-adapted therapy in essential thrombocythemia and polycythemia vera.
2005 Sep
Anagrelide: a review of its use in the management of essential thrombocythaemia.
2006
Patents

Patents

04146718
6
08530651
3
JP2001500865A
3
JP2011528275A
455
US3932407
3

Sample Use Guides

In Vivo Use Guide
0.5 mg qid or 1 mg bid (2 capsules of 0.5 mg twice a day) for at least one week
Route of Administration: Oral
In Vitro Use Guide
Anagrelide was studied as an inhibitor of PDE fractions I, II and III separated from each other from rabbit heart supernatant. Anagrelide did not inhibit PDE I or II except at a concentration of 10(-4) M where inhibition of 33 and 39%, respectively, was noted. As expected, anagrelide inhibited PDE fraction III with a dose-response curve that was closely similar to that seen in the human platelet preparation. The IC50 for inhibition of the rabbit heart PDE fraction III was 7 x 10(-8) M.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:51:16 GMT 2023
Edited
by admin
on Fri Dec 15 15:51:16 GMT 2023
Record UNII
K9X45X0051
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ANAGRELIDE
EMA EPAR   HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
ANAGRELIDE [HSDB]
Common Name English
Anagrelide [WHO-DD]
Common Name English
anagrelide [INN]
Common Name English
ANAGRELIDE [EMA EPAR]
Common Name English
6,7-DICHLORO-1,5-DIHYDROIMIDAZO(2,1-B)-QUINAZOLIN-2(3H)-ONE MONOHYDROCHLORIDE
Systematic Name English
ANAGRELIDE [VANDF]
Common Name English
IMIDAZO(2,1-B)QUINAZOLIN-2(3H)-ONE, 6,7-DICHLORO-1,5-DIHYDRO-, MONOHYDROCHLORIDE
Common Name English
ANAGRELIDE [MI]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 935223
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
LIVERTOX NBK548467
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
FDA ORPHAN DRUG 14586
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
NDF-RT N0000175972
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
FDA ORPHAN DRUG 20887
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
FDA ORPHAN DRUG 6985
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
WHO-VATC QL01XX35
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
NCI_THESAURUS C1327
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
NDF-RT N0000175638
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
WHO-ATC L01XX35
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID4048305
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
CHEBI
142290
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
NCI_THESAURUS
C28825
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
DRUG CENTRAL
209
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
EVMPD
SUB05499MIG
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
CAS
68475-42-3
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
MERCK INDEX
m1886
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY Merck Index
IUPHAR
7114
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
ChEMBL
CHEMBL760
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
FDA UNII
K9X45X0051
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
CHEBI
55345
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
WIKIPEDIA
ANAGRELIDE
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
SMS_ID
100000085241
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
PUBCHEM
135409400
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
LACTMED
Anagrelide
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
RXCUI
596724
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY RxNorm
DAILYMED
K9X45X0051
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
HSDB
7325
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
DRUG BANK
DB00261
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
INN
4672
Created by admin on Fri Dec 15 15:51:16 GMT 2023 , Edited by admin on Fri Dec 15 15:51:16 GMT 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 1A2
METABOLIC ENZYME -> SUBSTRATE
CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A
OFF-TARGET->INHIBITOR
IC50
Structure of ANAGRELIDE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
Structure of ANAGRELIDE
EXCRETED UNCHANGED
URINE
Structure of ANAGRELIDE HYDROCHLORIDE ANHYDROUS
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of RL-603
METABOLITE INACTIVE -> PARENT
Structure of 3-HYDROXY ANAGRELIDE
METABOLITE ACTIVE -> PARENT
Related Record Type Details
Structure of ANAGRELIDE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966