U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 18:07:15 GMT 2025
Edited
by admin
on Tue Apr 01 18:07:15 GMT 2025
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
JOC85XIO65
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CGI-PDE A
Preferred Name English
CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A
Common Name English
CYCLIC GMP-INHIBITED PHOSPHODIESTERASE A
Common Name English
PDE3A
Common Name English
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Systematic Name English
Code System Code Type Description
UNIPROT
Q14432
Created by admin on Tue Apr 01 18:07:15 GMT 2025 , Edited by admin on Tue Apr 01 18:07:15 GMT 2025
PRIMARY
FDA UNII
JOC85XIO65
Created by admin on Tue Apr 01 18:07:15 GMT 2025 , Edited by admin on Tue Apr 01 18:07:15 GMT 2025
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
IC50
INHIBITOR->OFF-TARGET
IC50
INHIBITOR -> TARGET
May be responsible for Cardiac related adverse events.
IC50
INHIBITOR -> TARGET
SELECTIVE INHIBITOR OF PDE3
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR->OFF-TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Could inhibit other PDE3 enzymes. inhibited cyclic AMP phosphodiesterase rude enzyme preparation from rabbit platelets.
IC50
INHIBITOR -> TARGET
INHIBITOR->OFF-TARGET
IC50

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_312] [1_492] [1_520] [1_524] [1_1033] DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_1036] THREONINE PHOSPHATE 3L4WX7B1EI
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL