U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CO3.Ca
Molecular Weight 100.087
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CALCIUM CARBONATE

SMILES

[Ca++].[O-]C([O-])=O

InChI

InChIKey=VTYYLEPIZMXCLO-UHFFFAOYSA-L
InChI=1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2

HIDE SMILES / InChI

Molecular Formula Ca
Molecular Weight 40.078
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula CO3
Molecular Weight 60.0089
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260884.htm | http://www.webmd.com/drugs/2/drug-159847/calcium-phosphate-dibasic-oral/details

Anhydrous dibasic calcium phosphate is a calcium salt of phosphoric acid. It is used as a diluent in pharmaceutical industry, in some toothpastes as a polishing agent. Calcium phosphate is generally recognized as safe by FDA. Dibasic calcium phosphate is ised as a supplement to treat conditions associated with calcium deficit, such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany)

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Hypocalcemia, chronic (treatment) — Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency, oral calcium salts may be administered concomitantly with vitamin D analogs. However, calcium phosphate should not be used in patients with hypoparathyroidism or renal failure, since phosphate levels may be too high and giving more phosphate would exacerbate the condition. Calcium supplements should not be used in hyperparathyroidism, unless the need for a calcium supplement is high and the patient is carefully monitored. For treatment of hypocalcemia, supplementation is preferred
PubMed

PubMed

TitleDatePubMed
1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes.
1999 Feb
Transient kinetic analysis of the 130-kDa myosin I (MYR-1 gene product) from rat liver. A myosin I designed for maintenance of tension?
1999 Jul 30
Characterization of the human cysteinyl leukotriene CysLT1 receptor.
1999 Jun 24
Ni2+ transport by the human Na+/Ca2+ exchanger expressed in Sf9 cells.
1999 May
Aluminum is a weak agonist for the calcium-sensing receptor.
1999 May
Modifications induced by LDL from type 1 diabetic patients on endothelial cells obtained from human umbilical vein.
1999 Nov
Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity.
1999 Sep 20
Cytosolic [Ca(2+)] modulates basal GLUT1 activity and plays a permissive role in its activation by metabolic stress and insulin in rat epithelial cells.
2000 Aug
Regulation of Na/K-ATPase beta1-subunit gene expression by ouabain and other hypertrophic stimuli in neonatal rat cardiac myocytes.
2000 Dec
Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors.
2000 Nov
Chemokines induce eosinophil degranulation through CCR-3.
2000 Sep
Pilocarpine-induced status epilepticus causes N-methyl-D-aspartate receptor-dependent inhibition of microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake.
2000 Sep
Ca2+-induced contraction of cat esophageal circular smooth muscle cells.
2001 Apr
Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity.
2001 Apr 27
Endothelin-induced changes of secondary messengers in cultured corneal endothelial cells.
2001 Aug
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel.
2001 Feb 16
Molecular and functional characterization of a family of rat brain T-type calcium channels.
2001 Feb 9
Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line.
2001 Jul
Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine.
2001 Jul
[Acute renal failure caused by hypercalcemia].
2001 Jun 10
Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy.
2001 Jun 8
Regression of ventral striatum hypometabolism after calcium/calcitriol therapy in paroxysmal kinesigenic choreoathetosis due to idiopathic primary hypoparathyroidism.
2001 Nov
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.
2001 Nov 1
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.
2001 Nov 30
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
2001 Oct
Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2+) channels.
2001 Oct 12
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.
2001 Oct 26
Regional differences in functional receptor distribution and calcium mobilization in the intact human lens.
2001 Sep
A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein.
2001 Sep 15
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.
2001 Sep 7
The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells.
2002 Apr 19
Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.
2002 Feb 1
Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.
2002 Jan 15
Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones.
2002 Jul
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.
2002 Jul 5
[Prevention of osteoporosis by foods and dietary supplements. Bioavailability of milk micellar calcium phosphate].
2006 Oct
Dietary calcium source influences body composition, glucose metabolism and hormone levels in a mouse model of postmenopausal obesity.
2009 Jul-Aug
Patents

Sample Use Guides

oral: 500 to 2000 mg elemental calcium a day, in divided doses (bid-qid). inhalation: In a single-blind, phase 1B proof of concept study, 24 subjects were enrolled to sequentially receive three doses of PUR118 (calcium lactate inhalation powder (CLIP) formulation) (5.5 mg, n = 18; 11.0 mg, n = 18; 2.8 mg, n = 16). Each dose was inhaled 3 times (1, 13, 25 h, preceded by 2 puffs salbutamol) before the ozone exposure (250 ppb, 3 h intermittent exercise). Sputum was induced 3 h after the end of exposure.
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:15:02 GMT 2023
Edited
by admin
on Fri Dec 15 16:15:02 GMT 2023
Record UNII
H0G9379FGK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CALCIUM CARBONATE
EP   FCC   HSDB   II   INCI   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
INS-170(I)
Code English
MARBLE DUST
Common Name English
CALCII CARBONAS [WHO-IP LATIN]
Common Name English
GLAUBERITUM
Common Name English
PRECPITATED CALCIUM CARBONATE [JAN]
Common Name English
LIMESTONE, GROUND
FCC  
Common Name English
HYDROLYZED PEARL
INCI  
INCI  
Official Name English
HYDROLYZED PEARL [INCI]
Common Name English
CALCIUM CARBONATE COMPONENT OF PEPCID COMPLETE
Common Name English
CALCITE [INCI]
Common Name English
Calcium carbonate (1:1)
Systematic Name English
CALCIUM CARBONATE [HSDB]
Common Name English
CALCITE
INCI  
Official Name English
CALCIUM (AS CARBONATE)
Common Name English
CALCIUM CARBONATE [FCC]
Common Name English
CALCIUM CARBONATE DC (SPRAY DRIED) [NDI]
Common Name English
NDI 443 [FDMS]
Code English
PEPCID COMPLETE COMPONENT CALCIUM CARBONATE
Common Name English
LIMESTONE, GROUND [FCC]
Common Name English
Chalk [WHO-DD]
Common Name English
CALCIUM CARBONATE [EP MONOGRAPH]
Common Name English
CALCIUM CARBONATE [WHO-IP]
Common Name English
CHALK
INCI   WHO-DD  
INCI  
Official Name English
HAN SHUI SHI
Common Name English
CALCITE (CA(CO3))
Common Name English
CALCIUM CARBONATE [MI]
Common Name English
CALCIUM CARBONATE [INCI]
Common Name English
CALCIUM CARBONATE [MART.]
Common Name English
CHALK [INCI]
Common Name English
E-170(I)
Code English
INS NO.170(I)
Code English
PHX CAL-CARB BUFFER
Brand Name English
CI 77220
INCI  
INCI  
Official Name English
CALCIUM (AS CALCIUM CARBONATE)
VANDF  
Common Name English
CALCIUM CARBONATE [USP-RS]
Common Name English
CALCIUM CARBONATE [USP MONOGRAPH]
Common Name English
CALCIUM CARBONATE [ORANGE BOOK]
Common Name English
CALCIUM (AS CALCIUM CARBONATE) [VANDF]
Common Name English
CALCIUM (AS CARBONATE) [VANDF]
Common Name English
LIMESTONE
Common Name English
CALCIUM CARBONATE [VANDF]
Common Name English
CALCITUM
Common Name English
PRECPITATED CALCIUM CARBONATE
JAN  
Common Name English
CALCIUM CARBONATE [II]
Common Name English
CI 77220 [INCI]
Common Name English
Calcium carbonate [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-VATC QA12AA04
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
EPA PESTICIDE CODE 73502
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
WHO-ATC A12AA04
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
CFR 21 CFR 178.3297
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
CFR 21 CFR 331.11
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
CFR 21 CFR 184.1191
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
JECFA EVALUATION INS-170(I)
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
LOINC 32156-2
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
WHO-VATC QA02AC01
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
CFR 21 CFR 176.170
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
CFR 21 CFR 331.15
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-170(I)
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
FDA ORPHAN DRUG 42189
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
CFR 21 CFR 184.1409
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
WHO-ATC A02AC01
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
Code System Code Type Description
DRUG BANK
DB06724
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
CONCEPT Dietary Supplement
MESH
D002119
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
CALCIUM CARBONATE
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY Description: A white, fine, microcrystalline powder; odourless. Solubility: Practically insoluble in water and ethanol (~750 g/l) TS. It dissolves with effervescence in acetic acid (~60 g/l) TS, hydrochloric acid (~70 g/l) TS, and nitric acid (~130 g/l) TS. Category: Antacid. Storage: Calcium carbonate should be kept in a well-closed container. Definition: Calcium carbonate contains not less than 98.0% and not more than 100.5% of CaCO3, calculated with reference to the dried substance.
EVMPD
SUB13166MIG
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
CAS
13397-26-7
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
ALTERNATIVE
ECHA (EC/EINECS)
207-439-9
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
CAS
1317-65-3
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
ALTERNATIVE
DAILYMED
H0G9379FGK
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
WIKIPEDIA
CALCIUM CARBONATE
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
PUBCHEM
10112
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
CHEBI
46719
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
CHEBI
31344
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
CAS
471-34-1
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
FDA UNII
H0G9379FGK
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
CAS
287389-46-2
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
ALTERNATIVE
CHEBI
3311
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-279-6
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
ALTERNATIVE
ChEMBL
CHEMBL1200539
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
RXCUI
1897
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
NCI_THESAURUS
C332
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
EPA CompTox
DTXSID3036238
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
HSDB
927
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
RS_ITEM_NUM
1086403
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
MERCK INDEX
m2929
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY Merck Index
DRUG CENTRAL
4239
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
SMS_ID
100000091518
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
PRIMARY
RXCUI
349908
Created by admin on Fri Dec 15 16:15:02 GMT 2023 , Edited by admin on Fri Dec 15 16:15:02 GMT 2023
ALTERNATIVE
Related Record Type Details
LABELED -> NON-LABELED
BINDER->LIGAND
BINDING
Related Record Type Details
ACTIVE MOIETY
http://apps.who.int/phint/pdf/b/Jb.6.1.68.pdf
ACTIVE MOIETY
ACTIVE MOIETY
ACTIVE MOIETY