CALCIUM CARBONATE

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	CO3.Ca
Molecular Weight	100.087
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Ca++].[O-]C([O-])=O

InChI

InChIKey=VTYYLEPIZMXCLO-UHFFFAOYSA-L

InChI=1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2

HIDE SMILES / InChI

Molecular Formula	CO3
Molecular Weight	60.0089
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Ca
Molecular Weight	40.078
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/inactive/calcium-phosphate-dibasic-anhydrous-463.htmlhttp://apps.who.int/iris/bitstream/10665/43579/1/9789241530729_eng.pdfhttp://www.globalrph.com/calcium_supplements.htm | https://www.ncbi.nlm.nih.gov/pubmed/26265479
Curator's Comment: description was created based on several sources, including https://www.alfa.com/en/catalog/043674/

Calcium lactate is the salt that consists of two lactate anions for each calcium cation (Ca2+); this salt is used as a calcium supplement to treat hypocalcemia. However, as a source of free calcium, this salt is less convenient than calcium citrate. Calcium lactate inhalation powder also called as PUR118 participated in phase I clinical trials to determine whether this formulation was safe and tolerable in a population of subjects with Cystic Fibrosis (CF). PUR118 also was used in another clinical trials to evaluate its effect on ozone-induced airway Inflammation in healthy normal volunteers in case of Chronic Obstructive Pulmonary Disease (COPD). The obtained results revealed that PUR118 reduced the severity of acute exacerbations in COPD and CF and had the beneficial impacts on mortality, morbidity, and quality of life in affected individuals. However, both studies were discontinued.

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2565
Hypocalcemia 75 Sources: http://www.globalrph.com/calcium_supplements.htm	Primary	Not Provided 503	Unknown Approved Use Unknown
Chronic obstructive pulmonary disease 173 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26265479	Palliative	Phase I 424	Unknown Approved Use Unknown
Cystic fibrosis 120 Sources: https://clinicaltrials.gov/ct2/show/NCT01543191	Palliative	Phase I 424	Unknown Approved Use Unknown
Unknown 2565
Hypocalcemia 75 Sources: https://www.drugs.com/mmx/calcium-phosphate-dibasic.html	Primary	Approved 8360	Unknown Approved Use Hypocalcemia, chronic (treatment) — Oral calcium supplements provide a source of calcium ion for treating calcium depletion occurring in conditions such as chronic hypoparathyroidism, pseudohypoparathyroidism, osteomalacia, rickets, chronic renal failure, and hypocalcemia secondary to the administration of anticonvulsant medications. When chronic hypocalcemia is due to vitamin D deficiency, oral calcium salts may be administered concomitantly with vitamin D analogs. However, calcium phosphate should not be used in patients with hypoparathyroidism or renal failure, since phosphate levels may be too high and giving more phosphate would exacerbate the condition. Calcium supplements should not be used in hyperparathyroidism, unless the need for a calcium supplement is high and the patient is carefully monitored. For treatment of hypocalcemia, supplementation is preferred

PubMed

Title	Date	PubMed
Studies on the calcemic effect of intravenous secretin in humans.	1975 Jun	1220513
Effects of terbutaline on force and intracellular calcium in slow-twitch skeletal muscle fibres of the rat.	1999 Apr	10372813
1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes.	1999 Feb	10048583
A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors.	1999 Feb 26	10026162
[Early stage of cardiomyopathy: mechanisms of damage and compensation].	1999 Jul	10643616
Modifications induced by LDL from type 1 diabetic patients on endothelial cells obtained from human umbilical vein.	1999 Nov	10535458
Cytosolic [Ca(2+)] modulates basal GLUT1 activity and plays a permissive role in its activation by metabolic stress and insulin in rat epithelial cells.	2000 Aug	10970766
Oim mice exhibit altered femur and incisor mineral composition and decreased bone mineral density.	2000 Aug	10913914
Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist.	2000 Dec	11093801
Inactivation properties of human recombinant class E calcium channels.	2000 Feb	10669483
Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors.	2000 Feb 15	10660688
Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.	2000 Jan 7	10617657
Hepatocyte growth factor disrupts cell contact and stimulates an increase in type 3 inositol triphosphate receptor expression, intracellular calcium levels, and apoptosis of rat ovarian surface epithelial cells.	2000 Jun	10963052
A family of gamma-like calcium channel subunits.	2000 Mar 24	10734232
ATP induces dephosphorylation of myosin light chain in endothelial cells.	2000 Sep	10942722
Pilocarpine-induced status epilepticus causes N-methyl-D-aspartate receptor-dependent inhibition of microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake.	2000 Sep	10936204
Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity.	2001 Aug 28	11513607
Complement activation in factor D-deficient mice.	2001 Dec 4	11724962
Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine.	2001 Jul	11435522
Analysis of the native quaternary structure of vanilloid receptor 1.	2001 Jul 27	11358970
Endothelin- and sarafotoxin-induced receptor-mediated calcium mobilization in a clonal murine osteoblast-like cell line, MC3T3-E1/B.	2001 Jun	11425647
Mechanisms of regulation of agonist efficacy at the 5-HT(1A) receptor by phospholipid-derived signaling components.	2001 Jun	11356925
Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities.	2001 Nov	11701772
Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors.	2001 Nov 1	11705452
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis.	2001 Nov 30	11577072
Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2+) channels.	2001 Oct 12	11597992
Regional differences in functional receptor distribution and calcium mobilization in the intact human lens.	2001 Sep	11527950
Heterologous expression of the Na(+),K(+)-ATPase gamma subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore.	2001 Sep 1	11533133
Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats.	2002	12421626
The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells.	2002 Apr 19	11830588
Interaction of intravenous anesthetics with recombinant human M1-M3 muscarinic receptors expressed in chinese hamster ovary cells.	2002 Dec	12456425
CXCR4 expression on monocytes is up-regulated by dexamethasone and is modulated by autologous CD3+ T cells.	2002 Feb	11872090
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.	2002 Feb	11796525
Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3.	2002 Feb 1	11826162
Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.	2002 Jan 15	11809688
Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones.	2002 Jul	12110441
Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intravenous calcium.	2002 Jul	12101159
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.	2002 Jul 5	11959854
Human kidney diamine oxidase: heterologous expression, purification, and characterization.	2002 Jun	12072962
Expression of functional CCR and CXCR chemokine receptors in podocytes.	2002 Jun 15	12055238
Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.	2002 Mar	11895442
Hypertension-related intermyocyte junction remodelling is associated with a higher incidence of low-K(+)-induced lethal arrhythmias in isolated rat heart.	2002 Mar	11856964
Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	2002 Mar 15	11897840
Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.	2002 May 15	11988098
Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons.	2002 Nov 4	12445469
Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.	2002 Sep	12181424
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.	2002 Sep 15	12069687
Effects of endothelin B receptor agonists on amyloid beta protein (25-35)-induced neuronal cell death.	2002 Sep 6	12383957
A critical interplay between Ca2+ inhibition and activation by Mg2+ of AC5 revealed by mutants and chimeric constructs.	2002 Sep 6	12065575
Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension.	2003 Jan	12388232

Patents

Sample Use Guides

In Vivo Use Guide

Proper administration of calcium carbonate or phosphate: Taking tablets 1 to 11/2 hours after meals, unless otherwise directed by physician. Recommended doses for adolescents and adults is 800-1200 mg/day; for pregnat orbreast-feeding females 1200 mg/day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Jul 05 23:42:16 UTC 2023` Edited by `admin` on `Wed Jul 05 23:42:16 UTC 2023`
Record UNII	H0G9379FGK
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CALCIUM CARBONATE

Official Name

English

INS-170(I)

Code

English

MARBLE DUST

Common Name

English

CALCII CARBONAS [WHO-IP LATIN]

Common Name

English

GLAUBERITUM

Common Name

English

PRECPITATED CALCIUM CARBONATE [JAN]

Common Name

English

LIMESTONE, GROUND

Common Name

English

HYDROLYZED PEARL

Official Name

English

HYDROLYZED PEARL [INCI]

Common Name

English

CALCIUM CARBONATE COMPONENT OF PEPCID COMPLETE

Common Name

English

CALCITE [INCI]

Common Name

English

Calcium carbonate (1:1)

Systematic Name

English

CALCIUM CARBONATE [HSDB]

Common Name

English

CALCITE

Common Name

English

CALCIUM (AS CARBONATE)

Common Name

English

CALCIUM CARBONATE [FCC]

Common Name

English

CALCIUM CARBONATE DC (SPRAY DRIED) [NDI]

Common Name

English

NDI 443 [FDMS]

Code

English

PEPCID COMPLETE COMPONENT CALCIUM CARBONATE

Common Name

English

LIMESTONE, GROUND [FCC]

Common Name

English

Chalk [WHO-DD]

Common Name

English

CALCIUM CARBONATE [EP MONOGRAPH]

Common Name

English

CALCIUM CARBONATE [WHO-IP]

Common Name

English

CHALK

Official Name

English

HAN SHUI SHI

Common Name

English

CALCITE (CA(CO3))

Common Name

English

CALCIUM CARBONATE [MI]

Common Name

English

CALCIUM CARBONATE [INCI]

Common Name

English

CALCIUM CARBONATE [MART.]

Common Name

English

CHALK [INCI]

Common Name

English

E-170(I)

Code

English

INS NO.170(I)

Code

English

PHX CAL-CARB BUFFER

Brand Name

English

CI 77220

Official Name

English

CALCIUM (AS CALCIUM CARBONATE)

Common Name

English

CALCIUM CARBONATE [USP-RS]

Common Name

English

CALCIUM CARBONATE [USP MONOGRAPH]

Common Name

English

CALCIUM CARBONATE [ORANGE BOOK]

Common Name

English

CALCIUM (AS CALCIUM CARBONATE) [VANDF]

Common Name

English

CALCIUM (AS CARBONATE) [VANDF]

Common Name

English

LIMESTONE

Common Name

English

CALCIUM CARBONATE [VANDF]

Common Name

English

CALCITUM

Common Name

English

PRECPITATED CALCIUM CARBONATE

Common Name

English

CALCIUM CARBONATE [II]

Common Name

English

CI 77220 [INCI]

Common Name

English

Calcium carbonate [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QA12AA04