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Details

Stereochemistry ACHIRAL
Molecular Formula CO3
Molecular Weight 60.0089
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -2

SHOW SMILES / InChI
Structure of CARBONATE ION

SMILES

[O-]C([O-])=O

InChI

InChIKey=BVKZGUZCCUSVTD-UHFFFAOYSA-L
InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2

HIDE SMILES / InChI

Molecular Formula CH2O3
Molecular Weight 62.0248
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Potash (Dihydroxyaluminum Sodium Carbonate), a component of Kompensan-S Forte in Germany, is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Kompensan-S Forte is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.

Originator

Curator's Comment: # Pfizer

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Kompensan

Approved Use

Gastrointestinal disorders: Dyspepsia, Duodenal Ulcer, Erosive Esophagitis, Gastric Ulcer, Gastroesophageal Reflux Disease, Zollinger-Ellison Syndrome, Hyperphosphatemia
PubMed

PubMed

TitleDatePubMed
Studies on antacids. V. The preparation and properties of dihydroxy aluminum sodium carbonate.
1955 Apr
Exchange of sodium by magnesium in aluminum hydroxycarbonate gel.
1984 Jul
Studies of neutralizing properties of antacid preparations. Part 4: Application of Weibull distribution function to neutralization of dihydroxyaluminum sodium carbonate.
1988 Jul
Effect of pepsin on the kinetics of HCl neutralization by dihydroxyaluminum sodium carbonate, hydrotalcite and dihydroxyaluminum aminoacetate.
1991
Patents

Sample Use Guides

Usual Adult Dose for Dyspepsia: 500 to 600 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Duodenal Ulcer: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Erosive Esophagitis: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Gastric Ulcer: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Gastroesophageal Reflux Disease: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Zollinger-Ellison Syndrome: 500 to 3600 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Hyperphosphatemia: 500 to 1000 mg orally 4 times a day, with meals and at bedtime. The dosage should be titrated to the serum phosphate level.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Thu Jul 06 00:23:03 UTC 2023
Edited
by admin
on Thu Jul 06 00:23:03 UTC 2023
Record UNII
7UJQ5OPE7D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CARBONATE ION
Common Name English
Carbonate [WHO-DD]
Common Name English
CARBONATE
WHO-DD  
Systematic Name English
Classification Tree Code System Code
LOINC 2033-9
Created by admin on Thu Jul 06 00:23:04 UTC 2023 , Edited by admin on Thu Jul 06 00:23:04 UTC 2023
DSLD 747 (Number of products:2)
Created by admin on Thu Jul 06 00:23:03 UTC 2023 , Edited by admin on Thu Jul 06 00:23:03 UTC 2023
LOINC 2034-7
Created by admin on Thu Jul 06 00:23:04 UTC 2023 , Edited by admin on Thu Jul 06 00:23:04 UTC 2023
NCI_THESAURUS C597
Created by admin on Thu Jul 06 00:23:04 UTC 2023 , Edited by admin on Thu Jul 06 00:23:04 UTC 2023
CFR 21 CFR 331.11
Created by admin on Thu Jul 06 00:23:03 UTC 2023 , Edited by admin on Thu Jul 06 00:23:03 UTC 2023
LOINC 14641-5
Created by admin on Thu Jul 06 00:23:04 UTC 2023 , Edited by admin on Thu Jul 06 00:23:04 UTC 2023
LOINC 2035-4
Created by admin on Thu Jul 06 00:23:04 UTC 2023 , Edited by admin on Thu Jul 06 00:23:04 UTC 2023
Code System Code Type Description
SMS_ID
100000125923
Created by admin on Thu Jul 06 00:23:04 UTC 2023 , Edited by admin on Thu Jul 06 00:23:04 UTC 2023
PRIMARY
WIKIPEDIA
CARBONATE
Created by admin on Thu Jul 06 00:23:04 UTC 2023 , Edited by admin on Thu Jul 06 00:23:04 UTC 2023
PRIMARY
MESH
D002254
Created by admin on Thu Jul 06 00:23:04 UTC 2023 , Edited by admin on Thu Jul 06 00:23:04 UTC 2023
PRIMARY
FDA UNII
7UJQ5OPE7D
Created by admin on Thu Jul 06 00:23:03 UTC 2023 , Edited by admin on Thu Jul 06 00:23:03 UTC 2023
PRIMARY
CAS
3812-32-6
Created by admin on Thu Jul 06 00:23:03 UTC 2023 , Edited by admin on Thu Jul 06 00:23:03 UTC 2023
PRIMARY
RXCUI
1544139
Created by admin on Thu Jul 06 00:23:04 UTC 2023 , Edited by admin on Thu Jul 06 00:23:04 UTC 2023
PRIMARY RxNorm
CHEBI
41609
Created by admin on Thu Jul 06 00:23:03 UTC 2023 , Edited by admin on Thu Jul 06 00:23:03 UTC 2023
PRIMARY
DRUG BANK
DB14531
Created by admin on Thu Jul 06 00:23:03 UTC 2023 , Edited by admin on Thu Jul 06 00:23:03 UTC 2023
PRIMARY
NCI_THESAURUS
C82598
Created by admin on Thu Jul 06 00:23:04 UTC 2023 , Edited by admin on Thu Jul 06 00:23:04 UTC 2023
PRIMARY
EVMPD
SUB32966
Created by admin on Thu Jul 06 00:23:03 UTC 2023 , Edited by admin on Thu Jul 06 00:23:03 UTC 2023
PRIMARY
EPA CompTox
DTXSID70872973
Created by admin on Thu Jul 06 00:23:03 UTC 2023 , Edited by admin on Thu Jul 06 00:23:03 UTC 2023
PRIMARY
PUBCHEM
19660
Created by admin on Thu Jul 06 00:23:04 UTC 2023 , Edited by admin on Thu Jul 06 00:23:04 UTC 2023
PRIMARY
DAILYMED
7UJQ5OPE7D
Created by admin on Thu Jul 06 00:23:03 UTC 2023 , Edited by admin on Thu Jul 06 00:23:03 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY