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Details

Stereochemistry ACHIRAL
Molecular Formula C19H20N2O2
Molecular Weight 308.3743
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENYLBUTAZONE

SMILES

CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=VYMDGNCVAMGZFE-UHFFFAOYSA-N
InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3

HIDE SMILES / InChI
Molecular Formula C19H20N2O2
Molecular Weight 308.3743
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Phenylbutazone is an anti-inflammatory drug, which binds to and inactivates cyclooxygenases and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues. Phenylbutazone was marked under the brand name butazolidin for the treatment rheumatoid arthritis and gout, but then this usage was discontinued. In addition, phenylbutazone is used in UK for the treatment of ankylosing spondylitis, but only in those cases, when other therapies are unsuitable.

Originator

Approval Year

1952
115
Targets

Targets

Primary TargetPharmacologyConditionPotency
Prostacyclin synthase
4
Target ID: Q16647
Gene ID: 5740.0
Gene Symbol: PTGIS
Target Organism: Homo sapiens (Human)
Inhibitor
8297
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Unknown

Approved Use

Unknown
Palliative
Approved
8429
BUTAZOLIDIN

Approved Use

Unknown
Palliative
Approved
8429
BUTAZOLIDIN

Approved Use

Unknown
Doses

Doses

DosePopulationAdverse events​
8 g single, oral
Overdose
Dose: 8 g
Route: oral
Route: single
Dose: 8 g
Sources:
https://pubmed.ncbi.nlm.nih.gov/7427601
healthy, 17 years
n = 1
Health Status: healthy
Age Group: 17 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/7427601
Other AEs: Renal disorder NOS, Jaundice...
Other AEs:
Renal disorder NOS
Jaundice
Sources:
https://pubmed.ncbi.nlm.nih.gov/7427601
800 mg 1 times / day multiple, oral
Highest studied dose
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
unhealthy, 52.8 years (range: 24-89 years)
Health Status: unhealthy
Condition: acute gouty arthritis
Age Group: 52.8 years (range: 24-89 years)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
Other AEs: Rash, Dyspepsia...
Other AEs:
Rash (1 patient)
Dyspepsia (1 patient)
Constipation (2 patients)
Sleepiness (1 patient)
Irritability (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
AEs

AEs

AESignificanceDosePopulation
Jaundice
8 g single, oral
Overdose
Dose: 8 g
Route: oral
Route: single
Dose: 8 g
Sources:
https://pubmed.ncbi.nlm.nih.gov/7427601
healthy, 17 years
n = 1
Health Status: healthy
Age Group: 17 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/7427601
Renal disorder NOS
8 g single, oral
Overdose
Dose: 8 g
Route: oral
Route: single
Dose: 8 g
Sources:
https://pubmed.ncbi.nlm.nih.gov/7427601
healthy, 17 years
n = 1
Health Status: healthy
Age Group: 17 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/7427601
Dyspepsia 1 patient
800 mg 1 times / day multiple, oral
Highest studied dose
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
unhealthy, 52.8 years (range: 24-89 years)
Health Status: unhealthy
Condition: acute gouty arthritis
Age Group: 52.8 years (range: 24-89 years)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
Irritability 1 patient
800 mg 1 times / day multiple, oral
Highest studied dose
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
unhealthy, 52.8 years (range: 24-89 years)
Health Status: unhealthy
Condition: acute gouty arthritis
Age Group: 52.8 years (range: 24-89 years)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
Rash 1 patient
800 mg 1 times / day multiple, oral
Highest studied dose
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
unhealthy, 52.8 years (range: 24-89 years)
Health Status: unhealthy
Condition: acute gouty arthritis
Age Group: 52.8 years (range: 24-89 years)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
Sleepiness 1 patient
800 mg 1 times / day multiple, oral
Highest studied dose
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
unhealthy, 52.8 years (range: 24-89 years)
Health Status: unhealthy
Condition: acute gouty arthritis
Age Group: 52.8 years (range: 24-89 years)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
Constipation 2 patients
800 mg 1 times / day multiple, oral
Highest studied dose
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
unhealthy, 52.8 years (range: 24-89 years)
Health Status: unhealthy
Condition: acute gouty arthritis
Age Group: 52.8 years (range: 24-89 years)
Sources:
https://pubmed.ncbi.nlm.nih.gov/3907678
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
inducer
781
inhibitor
1767

OverviewOther

Other InhibitorOther SubstrateOther Inducer
OAT1
599

OAT3
642

OAT4
146

MRP4
204

BCRP
699

MRP2
383

UGT1A6
108
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
MRP2
475
 no
BCRP
773
 partial
CYP2C9
1819
 yes [Ki 11 uM]
MRP4
238
 yes [Ki 354 uM]
OAT3
644
 yes [Ki 6.82 uM]
OAT1
603
 yes [Ki 71.6 uM]
CYP3A4
1925
 yes
OAT4
146
 yes
UGT1A6
141
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:48574
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:48574
ChemicalBook
CB0370134
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB0370134
MolPort
MolPort-001-783-564
https://www.molport.com/shop/molecule-link/MolPort-001-783-564
Selleck Chemicals
Phenylbutazone(Butazolidin)
http://www.selleckchem.com/products/Phenylbutazone(Butazolidin).html
ZINC
ZINC000100004227
http://zinc15.docking.org/substances/ZINC000100004227
eMolecules
27523332
https://www.emolecules.com/cgi-bin/more?vid=27523332
eMolecules
593834
https://www.emolecules.com/cgi-bin/more?vid=593834
PubMed

PubMed

TitleDatePubMed
[Renal complications following phenylbutazone treatment].
1966 May 19
Rheumatoid arthritis: comparison of treatment with monophenylbutazone and phenylbutazone.
1969 Dec 27
Treatment of aplastic anemia with nandrolone decanoate.
1970 Dec
Mefanamic acid-induced haemolytic anaemia.
1970 May 2
[Primary cardiac involvement and painful salivary gland enlargement due to phenylbutazone].
1974 Mar 1
Double-bind cross-over tiral of flurbiprofen and phenylbutazone in ankylosing spondylitis.
1974 Nov 30
Renal and gastric lesions after phenylbutazone and indomethacin in the rat.
1974 Oct
Letter: Idiosyncrasy to phenothiazines in phenylbutazone-associated aplastic anaemia.
1974 Oct 5
Further studies of the acute effects of phenylbutazone, oxyphenbutazone and indomethacin on the rat kidney.
1976 Apr
Aplastic anemia from veterinary phenylbutazone.
1976 Aug 30
[Evaluation of the effects of some non-steroid anti-inflammatory agents on the gastric mucosa].
1976 Jul 7
Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases.
1977 Jul
Association of renal papillary necrosis and ankylosing spondylitis.
1977 May
[Macroscopic hematuria during treatment with phenylbutazone derivatives. Positive lymphocyte transformation test for these drugs. Two cases in children].
1977 Oct
Renal papillary necrosis associated with indomethacin and phenylbutazone treated rheumatoid arthritis.
1978 Apr
Interstitial nephritis in a case of phenylbutazone hypersensitivity.
1978 May 20
Exacerbation of phenylbutazone-related renal failure by indomethacin.
1978 Nov
Use of phenylbutazone in sports medicine: understanding the risks.
1980 Jul-Aug
Intrahepatic cholestasis induced by phenylbutazone.
1981
Acute nephrotic syndrome with reversible renal failure after phenylbutazone.
1981 Mar 21
Phenylbutazone liver injury: a clinical-pathologic survey of 23 cases and review of the literature.
1981 May-Jun
Animal experiments on the safety pharmacology of lofexidine.
1982
Effects of large doses of phenylbutazone administration to horses.
1983 May
[Kidney damage after treatment with butapyrazole].
1983 Nov 15
Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies.
1985 Sep-Oct
Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10.
1996 Dec
Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies.
1997 Apr 15
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.
1997 Jan 10
Development of an in vitro reporter gene assay to assess xenobiotic induction of the human CYP3A4 gene.
1997 Oct-Dec
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.
1999 Mar
Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes.
1999 May
Renal papillary necrosis.
2002 Nov-Dec
Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation.
2004 Dec 9
Immunomodulatory effect of nonsteroidal anti-inflammatory drugs (NSAIDs) at the clinically available doses.
2007 Jan
Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database.
2009 Nov 9
Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.
2011 Feb
Characterization of UDP-glucuronosyltransferases involved in glucuronidation of diethylstilbestrol in human liver and intestine.
2012 Dec 17
Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.
2012 Oct 2
FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.
2013 Sep 5
Patents

Patents

JPS5815912A
4

Sample Use Guides

In Vivo Use Guide
300 mg daily for 4 weeks
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:16:04 GMT 2023
Edited
by admin
on Fri Dec 15 15:16:04 GMT 2023
Record UNII
GN5P7K3T8S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHENYLBUTAZONE
EP   GREEN BOOK   HSDB   INN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
INN  
Official Name English
SHIGRODIN
Common Name English
AMBENE
Brand Name English
PHEBUZINE
Common Name English
FLEXAZONE
Common Name English
BUTAPIRAZOL
Brand Name English
DIPHENYLBUTAZONE
Common Name English
3,5-PYRAZOLIDINEDIONE, 4-BUTYL-1,2-DIPHENYL-
Systematic Name English
ROBIZONE-V
Brand Name English
3,5-DIOXO-1,2-DIPHENYL-4-N-BUTYLPYRAZOLIDINE
Common Name English
PHENYLBUTAZONE [MART.]
Common Name English
EXRHEUDON N
Brand Name English
FENYLBUTAZON
Common Name English
PHENYLBUTAZONE [USP-RS]
Common Name English
BUTACOTE
Brand Name English
FENIBUTAZONA
Common Name English
phenylbutazone [INN]
Common Name English
BUTAZOLIDIN
Brand Name English
4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
Systematic Name English
ARTRIZIN
Brand Name English
NSC-25134
Code English
INTRABUTAZONE
Brand Name English
BUTADIONA
Brand Name English
ZOLAPHEN
Common Name English
FENIBUTOL
Brand Name English
SUXIBUZONE IMPURITY A [EP IMPURITY]
Common Name English
Phenylbutazone [WHO-DD]
Common Name English
MEPHA-BUTAZON
Brand Name English
BUZON
Brand Name English
PHENYLBUTAZONE [MI]
Common Name English
PHENYLBUTAZONE [USP MONOGRAPH]
Common Name English
AZOLID
Systematic Name English
PHENYZENE
Brand Name English
INTRAZONE
Brand Name English
UZONE
Brand Name English
EQUIPALAZONE
Brand Name English
BUTATRON
Brand Name English
PHENYLBUTAZONE [JAN]
Common Name English
PHENYLBUTAZONE [GREEN BOOK]
Common Name English
PHENYLBUTAZONE [ORANGE BOOK]
Common Name English
PHENYLBUTAZONE [VANDF]
Common Name English
R-3-ZON
Code English
PHENYLBUTAZONE [IARC]
Common Name English
DIPHEBUZOL
Common Name English
PHENYLBUTAZONE [HSDB]
Common Name English
4-BUTYL-1,2-DIPHENYL-3,5-DIOXOPYRAZOLIDINE
Systematic Name English
BUTOZ
Brand Name English
BUTADION
Brand Name English
BIZOLIN
Brand Name English
PHENYLBUTAZONE [EP MONOGRAPH]
Common Name English
ECOBUTAZONE
Brand Name English
TEVCODYNE
Brand Name English
G-13871
Code English
Classification Tree Code System Code
CFR 21 CFR 522.1720
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
CFR 21 CFR 520.1720D
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
CFR 21 CFR 520.1720
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
CFR 21 CFR 520.1720B
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
CFR 21 CFR 520.1720C
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
CFR 21 CFR 520.1720A
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
NCI_THESAURUS C257
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
WHO-VATC QM02AA01
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
CFR 21 CFR 520.1720E
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
WHO-VATC QM01BA01
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
WHO-ATC M02AA01
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
IARC Phenylbutazone
WHO-VATC QM01AA01
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
WHO-ATC M01BA01
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
WHO-ATC M01AA01
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
Code System Code Type Description
MERCK INDEX
m8660
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY Merck Index
RS_ITEM_NUM
1531007
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
ChEMBL
CHEMBL101
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
FDA UNII
GN5P7K3T8S
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
WIKIPEDIA
PHENYLBUTAZONE
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
RXCUI
8160
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY RxNorm
NCI_THESAURUS
C66377
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-029-0
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
EPA CompTox
DTXSID9021136
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
EVMPD
SUB09787MIG
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
CAS
50-33-9
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
PUBCHEM
4781
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
SMS_ID
100000092182
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
IUPHAR
7270
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
HSDB
3159
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
DRUG BANK
DB00812
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
INN
4
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
NSC
25134
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
DAILYMED
GN5P7K3T8S
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
CHEBI
48574
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
DRUG CENTRAL
2145
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
MESH
D010653
Created by admin on Fri Dec 15 15:16:04 GMT 2023 , Edited by admin on Fri Dec 15 15:16:04 GMT 2023
PRIMARY
Related Record Type Details
Structure of PROXIFEZONE
SALT/SOLVATE -> PARENT
Structure of CLOFEZONE ANHYDROUS
SALT/SOLVATE -> PARENT
Structure of PHENYLBUTAZONE PIPERAZINE
SALT/SOLVATE -> PARENT
Structure of CLOFEZONE
SALT/SOLVATE -> PARENT
Structure of PHENYLBUTAZONE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
Structure of DIETHANOLAMINE PHENYLBUTAZONE
SALT/SOLVATE -> PARENT
Structure of PHENYLBUTAZONE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
Structure of THIAZOLINOBUTAZONE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of OXYPHENBUTAZONE
METABOLITE ACTIVE -> PARENT
Metabolite to parent drug ratio in non-uraemic human plasma.
METABOLITE TO PARENT DRUG RATIO
PLASMA; URINE
Structure of OXYPHENBUTAZONE
METABOLITE ACTIVE -> PARENT
Oxyphenbutazone, having the same antirheumatic and sodium retaining activities as phenylbutazone, is in clinical use.
Structure of OXYPHENBUTAZONE
METABOLITE ACTIVE -> PARENT
Percent of dose excreted in urine as metabolite.
AMOUNT ADMINISTERED
URINE
Related Record Type Details
Structure of BENZIDINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of AZOBENZENE
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of BUMADIZONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of SUXIBUZONE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 1,2-DIPHENYLHYDRAZINE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 0.55
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 4-HYDROXYPHENYLBUTAZONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of PHENYLBUTAZONE
ACTIVE MOIETY
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