CLOFEZONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H20N2O2.C14H21ClN2O2.2H2O
Molecular Weight	629.187
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O.CCN(CC)CCNC(=O)COC1=CC=C(Cl)C=C1.CCCCC2C(=O)N(N(C2=O)C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=FNOZOEQGHOYGSF-UHFFFAOYSA-N

InChI=1S/C19H20N2O2.C14H21ClN2O2.2H2O/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16;1-3-17(4-2)10-9-16-14(18)11-19-13-7-5-12(15)6-8-13;;/h4-13,17H,2-3,14H2,1H3;5-8H,3-4,9-11H2,1-2H3,(H,16,18);2*1H2

HIDE SMILES / InChI

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C19H20N2O2
Molecular Weight	308.3743
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C14H21ClN2O2
Molecular Weight	284.782
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/153679 | https://www.ncbi.nlm.nih.gov/pubmed/5555631 | https://www.ncbi.nlm.nih.gov/pubmed/4927184 | https://www.ncbi.nlm.nih.gov/pubmed/132816

Clofezone (Perclusone), an analgesic and anti-inflammatory agent, is a drug that was used to treat joint and muscular pain, mostly in rheumatic diseases. Clofezone is a compound preparation of phenylbutazone and clofexamide. Tolerance of Perclusone was very good, no side-effects were observed.

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

The effectiveness and acceptability of clofezone (Perclusone) were compared with those of diclofenac in a placebo-controlled, double-blind, cross-over trial on a group of 29 out-patients suffering from osteoarthrosis of the knee or hip. Clofezone was given at a daily dosage of 1200 mg during the first week and 600 mg during the second week; the corresponding dosages of diclofenac were 150 mg and 75 mg.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:12:39 UTC 2023` Edited by `admin` on `Fri Dec 15 16:12:39 UTC 2023`
Record UNII	TPT3MH65LD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOFEZONE

Official Name

English

Clofezone [WHO-DD]

Common Name

English

CLOFEZONE DIHYDRATE

Common Name

English

ACETAMIDE, 2-(4-CHLOROPHENOXY)-N-(2-(DIETHYLAMINO)ETHYL)-, COMPD. WITH 4-BUTYL-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE, HYDRATE (1:1:2)

Systematic Name

English

CLOFEZONE [MART.]

Common Name

English

ANP-3260

Code

English

clofezone [INN]

Common Name

English

CLOFEZONE [JAN]

Common Name

English

ANP 3260

Code

English

Classification Tree Code System Code

WHO-VATC

QM01AA05