Clofexamide (or Amichlophene) is an antidepressant that was a component of the drug combination clofezone, the other being the nonsteroidal anti-inflammatory drug (NSAID) phenylbutazone. Clofezone potentiated hexobarbital-induced sleep in mice, prevented tolerance to morphine, increased uterine motility in rabbits, inhibited Pentetrazole seizure and toxic effects of bacterial polysaccharides in mice, inhibited the action potential of rat sciatic nerves, but had no significant effect on blood pressure, heart function, blood coagulation, hemolysis, respiration, or intestinal motility in rabbits. Clofezone was used to treat joint and muscular pain but is not marketed anymore.