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Details

Stereochemistry ACHIRAL
Molecular Formula C14H21ClN2O2
Molecular Weight 284.782
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOFEXAMIDE

SMILES

CCN(CC)CCNC(=O)COC1=CC=C(Cl)C=C1

InChI

InChIKey=UORGKWWJEQDTGX-UHFFFAOYSA-N
InChI=1S/C14H21ClN2O2/c1-3-17(4-2)10-9-16-14(18)11-19-13-7-5-12(15)6-8-13/h5-8H,3-4,9-11H2,1-2H3,(H,16,18)

HIDE SMILES / InChI

Molecular Formula C14H21ClN2O2
Molecular Weight 284.782
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Clofexamide (or Amichlophene) is an antidepressant that was a component of the drug combination clofezone, the other being the nonsteroidal anti-inflammatory drug (NSAID) phenylbutazone. Clofezone potentiated hexobarbital-induced sleep in mice, prevented tolerance to morphine, increased uterine motility in rabbits, inhibited Pentetrazole seizure and toxic effects of bacterial polysaccharides in mice, inhibited the action potential of rat sciatic nerves, but had no significant effect on blood pressure, heart function, blood coagulation, hemolysis, respiration, or intestinal motility in rabbits. Clofezone was used to treat joint and muscular pain but is not marketed anymore.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Clofezone

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
0.4 g phenylbutazone or 0.8 g clofezone
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
071P4J77HF
Record Status Validated (UNII)
Record Version