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Details

Stereochemistry ACHIRAL
Molecular Formula C14H21ClN2O2.ClH
Molecular Weight 321.243
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOFEXAMIDE HYDROCHLORIDE

SMILES

Cl.CCN(CC)CCNC(=O)COC1=CC=C(Cl)C=C1

InChI

InChIKey=FIWBEGJXLDEFDE-UHFFFAOYSA-N
InChI=1S/C14H21ClN2O2.ClH/c1-3-17(4-2)10-9-16-14(18)11-19-13-7-5-12(15)6-8-13;/h5-8H,3-4,9-11H2,1-2H3,(H,16,18);1H

HIDE SMILES / InChI
Molecular Formula C14H21ClN2O2
Molecular Weight 284.782
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/122234

Clofexamide (or Amichlophene) is an antidepressant that was a component of the drug combination clofezone, the other being the nonsteroidal anti-inflammatory drug (NSAID) phenylbutazone. Clofezone potentiated hexobarbital-induced sleep in mice, prevented tolerance to morphine, increased uterine motility in rabbits, inhibited Pentetrazole seizure and toxic effects of bacterial polysaccharides in mice, inhibited the action potential of rat sciatic nerves, but had no significant effect on blood pressure, heart function, blood coagulation, hemolysis, respiration, or intestinal motility in rabbits. Clofezone was used to treat joint and muscular pain but is not marketed anymore.

Originator

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
Clofezone

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Effect of hypoxia on mitochondrial stability].
1976-04-01
Patents

Patents

FR400
2

Sample Use Guides

In Vivo Use Guide
0.4 g phenylbutazone or 0.8 g clofezone
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 21:45:40 GMT 2025
Edited
by admin
on Mon Mar 31 21:45:40 GMT 2025
Record UNII
XF53W63942
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
J383.153A
Preferred Name English
CLOFEXAMIDE HYDROCHLORIDE
Common Name English
ACETAMIDE, 2-(P-CHLOROPHENOXY)-N-(2-(DIETHYLAMINO)ETHYL)-, HYDROCHLORIDE
Systematic Name English
2-(4-CHLOROPHENOXY)-N-(2-(DIETHYLAMINO)ETHYL)ACETAMIDE MONOHYDROCHLORIDE
Systematic Name English
ACETAMIDE, 2-(4-CHLOROPHENOXY)-N-(2-(DIETHYLAMINO)ETHYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
Clofexamide hydrochloride [WHO-DD]
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
222-466-6
Created by admin on Mon Mar 31 21:45:40 GMT 2025 , Edited by admin on Mon Mar 31 21:45:40 GMT 2025
PRIMARY
PUBCHEM
197791
Created by admin on Mon Mar 31 21:45:40 GMT 2025 , Edited by admin on Mon Mar 31 21:45:40 GMT 2025
PRIMARY
FDA UNII
XF53W63942
Created by admin on Mon Mar 31 21:45:40 GMT 2025 , Edited by admin on Mon Mar 31 21:45:40 GMT 2025
PRIMARY
EPA CompTox
DTXSID40956299
Created by admin on Mon Mar 31 21:45:40 GMT 2025 , Edited by admin on Mon Mar 31 21:45:40 GMT 2025
PRIMARY
RXCUI
236177
Created by admin on Mon Mar 31 21:45:40 GMT 2025 , Edited by admin on Mon Mar 31 21:45:40 GMT 2025
PRIMARY
CAS
3482-74-4
Created by admin on Mon Mar 31 21:45:40 GMT 2025 , Edited by admin on Mon Mar 31 21:45:40 GMT 2025
PRIMARY
Related Record Type Details
Structure of CLOFEXAMIDE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of CLOFEXAMIDE
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