PROXIFEZONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H29NO2.C19H20N2O2
Molecular Weight	647.8455
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3.CCC(=O)O[C@@](CC4=CC=CC=C4)([C@H](C)CN(C)C)C5=CC=CC=C5

InChI

InChIKey=CSCJLERKCQBWJV-MYXGOWFTSA-N

InChI=1S/C22H29NO2.C19H20N2O2/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h6-15,18H,5,16-17H2,1-4H3;4-13,17H,2-3,14H2,1H3/t18-,22+;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C19H20N2O2
Molecular Weight	308.3743
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C22H29NO2
Molecular Weight	339.4712
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=19710212&CC=FR&NR=2042342A1&KC=A1 | Therapie (1972), 27, (3), 483-9.

Proxifezone is a mixture of phenylbutazone and d-propoxyphene patented by Societe d'Etudes de Recherches et d'Applications Scientifiques et Medicales E.R.A.S.M.E. as an anti-inflammation pharmaceutical composition with potent analgesic activity. Anti-inflammatory effects of Proxifezone associated with Phenylbutazone, that acts as a nonsteroidal anti-inflammatory drug (NSAID). D-propoxyphene acts as an opioid analgesic, that provides strong pain relief.

Originator

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:36:47 GMT 2023` Edited by `admin` on `Fri Dec 15 16:36:47 GMT 2023`
Record UNII	005MKH0F6D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROXIFEZONE

Official Name

English

(+)-4-(DIMETHYLAMINO)-3-METHYL-1,2-DIPHENYL-2-BUTANOL PROPIONATE (ESTER) COMPOUND WITH 4-BUTYL-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE (1:1)

Common Name

English

proxifezone [INN]

Common Name

English

PROPOXYPHENE PHENYLBUTAZONATE, (+)-

Common Name

English

(+)-PROPOXYPHENE PHENYLBUTAZONATE

Common Name

English

3,5-PYRAZOLIDINEDIONE, 4-BUTYL-1,2-DIPHENYL-, COMPD. WITH (1S,2R)-3-(DIMETHYLAMINO)-2-METHYL-1-PHENYL-1-(PHENYLMETHYL)PROPYL PROPANOATE (1:1)

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C266