Althiazide

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H14ClN3O4S3
Molecular Weight	383.895
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NS(=O)(=O)C1=CC2=C(NC(CSCC=C)NS2(=O)=O)C=C1Cl

InChI

InChIKey=VGLGVJVUHYTIIU-UHFFFAOYSA-N

InChI=1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)

HIDE SMILES / InChI

Molecular Formula	C11H14ClN3O4S3
Molecular Weight	383.895
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2191585 | https://www.ncbi.nlm.nih.gov/pubmed/612384

Altizide, a thiazide diuretic, and aldosterone antagonist, in combination with spironolactone was marketed under brand name Aldactazine to treat patients with mild to moderate hypertension. In addition, Aldactazine was investigated for the treatment of congestive cardiac insufficiency.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Thiazide-sensitive sodium-chloride cotransporter 28 Target ID: CHEMBL1876 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1972313 \| https://www.ncbi.nlm.nih.gov/pubmed/2191585	Inhibitor 8297

PubMed

Title	Date	PubMed
Effects of pH and the presence of micelles on the resolution of diuretics by reversed-phase liquid chromatography.	2004 Jan 2	14753771
Mechanism of [m+h]+ formation in atmospheric pressure photoionization mass spectrometry: identification of propionitrile in acetonitrile with high mass accuracy measurement and tandem mass spectrometry and evidence for its involvement in the protonation phenomenon.	2008 Nov	18667333
A case of brucellar spondylodiscitis involving the cervical spine.	2009	20023340
Stability of selected chlorinated thiazide diuretics.	2009 Feb 20	19108977
Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis.	2009 Mar 20	19187939
Probing the allosteric modulator binding site of GluR2 with thiazide derivatives.	2009 Sep 15	19673491
Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories.	2010 Apr	20155493

Sample Use Guides

In Vivo Use Guide

Aldactazine ( 25 mg spironolactone and 15 mg altizide, 1/day)

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:12:48 GMT 2023` Edited by `admin` on `Fri Dec 15 16:12:48 GMT 2023`
Record UNII	GI8CB72B0D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Althiazide

Official Name

English

ALTHIAZIDE [USAN]

Common Name

English

Altizide

Official Name

English

NSC-757786

Code

English

Altizide [WHO-DD]

Common Name

English

altizide [INN]

Common Name

English

ALTIZIDE [MART.]

Common Name

English

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-[(2-propen-1-ylthio)methyl]-, 1,1-dioxide

Systematic Name

English

3-[(Allylthio)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Systematic Name

English

ALTIZIDE [EP IMPURITY]

Common Name

English

ALTIZIDE [EP MONOGRAPH]

Common Name

English

P-1779

Code

English

Classification Tree Code System Code

WHO-VATC

QC03EA04