U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C11H14ClN3O4S3
Molecular Weight 383.8982
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALTHIAZIDE

SMILES

C=CCSCC1Nc2cc(c(cc2S(=O)(=O)N1)S(=O)(=O)N)Cl

InChI

InChIKey=VGLGVJVUHYTIIU-UHFFFAOYSA-N
InChI=1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)

HIDE SMILES / InChI

Molecular Formula C11H14ClN3O4S3
Molecular Weight 383.8982
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Altizide, a thiazide diuretic, and aldosterone antagonist, in combination with spironolactone was marketed under brand name Aldactazine to treat patients with mild to moderate hypertension. In addition, Aldactazine was investigated for the treatment of congestive cardiac insufficiency.

Approval Year

PubMed

PubMed

TitleDatePubMed
[Management of bronchiolitis in the infant. Recommendations. Long text].
2001 Jan
Effects of pH and the presence of micelles on the resolution of diuretics by reversed-phase liquid chromatography.
2004 Jan 2
High-speed gas chromatography in doping control: fast-GC and fast-GC/MS determination of beta-adrenoceptor ligands and diuretics.
2006 Dec
Fast gas chromatographic/mass spectrometric determination of diuretics and masking agents in human urine: Development and validation of a productive screening protocol for antidoping analysis.
2006 Dec 1
Synthesis and application of mono-2A-azido-2A-deoxyperphenylcarbamoylated beta-cyclodextrin and mono-2A-azido-2A-deoxyperacetylated beta-cyclodextrin as chiral stationary phases for high-performance liquid chromatography.
2006 Jan 6
Mechanism of [m+h]+ formation in atmospheric pressure photoionization mass spectrometry: identification of propionitrile in acetonitrile with high mass accuracy measurement and tandem mass spectrometry and evidence for its involvement in the protonation phenomenon.
2008 Nov
A case of brucellar spondylodiscitis involving the cervical spine.
2009
Stability of selected chlorinated thiazide diuretics.
2009 Feb 20
Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis.
2009 Mar 20
Probing the allosteric modulator binding site of GluR2 with thiazide derivatives.
2009 Sep 15
Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories.
2010 Apr

Sample Use Guides

Aldactazine ( 25 mg spironolactone and 15 mg altizide, 1/day)
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Jun 25 21:15:14 UTC 2021
Edited
by admin
on Fri Jun 25 21:15:14 UTC 2021
Record UNII
GI8CB72B0D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALTHIAZIDE
MI   USAN  
USAN  
Official Name English
ALTHIAZIDE [USAN]
Common Name English
ALTIZIDE
EP   INN   MART.   WHO-DD  
INN  
Official Name English
2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE, 6-CHLORO-3,4-DIHYDRO-3-((2-PROPENYLTHIO)METHYL)-, 1,1-DIOXIDE
Systematic Name English
NSC-757786
Code English
ALTIZIDE [EP]
Common Name English
ALTIZIDE [INN]
Common Name English
ALTIZIDE [MART.]
Common Name English
3-((ALLYLTHIO)METHYL)-6-CHLORO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
Systematic Name English
ALTIZIDE [EP MONOGRAPH]
Common Name English
ALTIZIDE [WHO-DD]
Common Name English
P-1779
Code English
Classification Tree Code System Code
WHO-VATC QC03EA04
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
NCI_THESAURUS C49185
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
WHO-ATC C03EA04
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
Code System Code Type Description
EVMPD
SUB05379MIG
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY
MERCK INDEX
M1584
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY Merck Index
PUBCHEM
2122
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY
ChEMBL
CHEMBL599870
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY
INN
1382
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY
RXCUI
17599
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY RxNorm
DRUG CENTRAL
140
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY
EPA CompTox
5588-16-9
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY
CAS
5588-16-9
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY
ECHA (EC/EINECS)
226-994-8
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY
FDA UNII
GI8CB72B0D
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY
NCI_THESAURUS
C80838
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY
MESH
C006480
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY
WIKIPEDIA
ALTIZIDE
Created by admin on Fri Jun 25 21:15:14 UTC 2021 , Edited by admin on Fri Jun 25 21:15:14 UTC 2021
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
Related Record Type Details
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (TLC)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
ACTIVE MOIETY