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Details

Stereochemistry ABSOLUTE
Molecular Formula C11H14ClN3O4S3
Molecular Weight 383.895
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Althiazide, (R)-

SMILES

NS(=O)(=O)C1=CC2=C(N[C@@H](CSCC=C)NS2(=O)=O)C=C1Cl

InChI

InChIKey=VGLGVJVUHYTIIU-LLVKDONJSA-N
InChI=1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)/t11-/m1/s1

HIDE SMILES / InChI

Molecular Formula C11H14ClN3O4S3
Molecular Weight 383.895
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Altizide, a thiazide diuretic, and aldosterone antagonist, in combination with spironolactone was marketed under brand name Aldactazine to treat patients with mild to moderate hypertension. In addition, Aldactazine was investigated for the treatment of congestive cardiac insufficiency.

Approval Year

PubMed

PubMed

TitleDatePubMed
Synthesis and application of mono-2A-azido-2A-deoxyperphenylcarbamoylated beta-cyclodextrin and mono-2A-azido-2A-deoxyperacetylated beta-cyclodextrin as chiral stationary phases for high-performance liquid chromatography.
2006 Jan 6
A case of brucellar spondylodiscitis involving the cervical spine.
2009

Sample Use Guides

Aldactazine ( 25 mg spironolactone and 15 mg altizide, 1/day)
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:46:53 UTC 2023
Edited
by admin
on Sat Dec 16 09:46:53 UTC 2023
Record UNII
D9KLS88BLV
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Althiazide, (R)-
Common Name English
(R)-Althiazide
Common Name English
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-[(2-propen-1-ylthio)methyl]-, 1,1-dioxide, (3R)-
Systematic Name English
Code System Code Type Description
FDA UNII
D9KLS88BLV
Created by admin on Sat Dec 16 09:46:53 UTC 2023 , Edited by admin on Sat Dec 16 09:46:53 UTC 2023
PRIMARY
PUBCHEM
6604323
Created by admin on Sat Dec 16 09:46:53 UTC 2023 , Edited by admin on Sat Dec 16 09:46:53 UTC 2023
PRIMARY
CAS
2242522-74-1
Created by admin on Sat Dec 16 09:46:53 UTC 2023 , Edited by admin on Sat Dec 16 09:46:53 UTC 2023
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER