Althiazide, (S)-

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C11H14ClN3O4S3
Molecular Weight	383.895
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

NS(=O)(=O)C1=C(Cl)C=C2N[C@H](CSCC=C)NS(=O)(=O)C2=C1

InChI

InChIKey=VGLGVJVUHYTIIU-NSHDSACASA-N

InChI=1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)/t11-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C11H14ClN3O4S3
Molecular Weight	383.895
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description

Altizide, a thiazide diuretic, and aldosterone antagonist, in combination with spironolactone was marketed under brand name Aldactazine to treat patients with mild to moderate hypertension. In addition, Aldactazine was investigated for the treatment of congestive cardiac insufficiency.

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Thiazide-sensitive sodium-chloride cotransporter 28	Inhibitor 8,504

PubMed

PubMed

Show entries

Title	Date	PubMed
High-speed gas chromatography in doping control: fast-GC and fast-GC/MS determination of beta-adrenoceptor ligands and diuretics.	2006 Dec	17305237
Fast gas chromatographic/mass spectrometric determination of diuretics and masking agents in human urine: Development and validation of a productive screening protocol for antidoping analysis.	2006 Dec 1	17027009
Synthesis and application of mono-2A-azido-2A-deoxyperphenylcarbamoylated beta-cyclodextrin and mono-2A-azido-2A-deoxyperacetylated beta-cyclodextrin as chiral stationary phases for high-performance liquid chromatography.	2006 Jan 6	16236286
Mechanism of [m+h]+ formation in atmospheric pressure photoionization mass spectrometry: identification of propionitrile in acetonitrile with high mass accuracy measurement and tandem mass spectrometry and evidence for its involvement in the protonation phenomenon.	2008 Nov	18667333
Stability of selected chlorinated thiazide diuretics.	2009 Feb 20	19108977

Showing 1 to 5 of 6 entries

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Sample Use Guides

In Vivo Use Guide

Aldactazine ( 25 mg spironolactone and 15 mg altizide, 1/day)

Route of Administration: Oral

Substance Class	Chemical
Record UNII	JI3ZO158IN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Althiazide, (S)-

Common Name

English

(S)-Althiazide

Preferred Name

English

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-[(2-propen-1-ylthio)methyl]-, 1,1-dioxide, (3S)-

Systematic Name

English

Showing 1 to 3 of 3 entries

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Code System

Code

Type

Description

FDA UNII

JI3ZO158IN

PRIMARY

PUBCHEM

38988913

PRIMARY

CAS

2242522-75-2

PRIMARY

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Related Record

Type

Details


					GI8CB72B0D

Althiazide

RACEMATE -> ENANTIOMER

Amount:

Showing 1 to 1 of 1 entries

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