FLEROBUTEROL

Details

Stereochemistry	RACEMIC
Molecular Formula	C12H18FNO
Molecular Weight	211.2758
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)NCC(O)C1=C(F)C=CC=C1

InChI

InChIKey=XTJMTDZHCLBKFU-UHFFFAOYSA-N

InChI=1S/C12H18FNO/c1-12(2,3)14-8-11(15)9-6-4-5-7-10(9)13/h4-7,11,14-15H,8H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C12H18FNO
Molecular Weight	211.2758
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1676181 | https://www.ncbi.nlm.nih.gov/pubmed/10704268

FLEROBUTEROL is a beta-adrenoceptor agonist with potential antidepressant activity.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Effects of CRL 40827 and salbutamol on exocrine pancreatic secretion in rats.	1988 Jan 27	2895009
Flerobuterol, a beta-adrenoceptor agonist, enhances serotonergic neurotransmission: an electrophysiological study in the rat brain.	1991	1676181
Flerobuterol: a potential antidepressant drug related to beta-adrenergic agonists. Experimental profile in mice.	1991	1686009
Evidence for different interactions between beta(1)- and beta(2)-adrenoceptor subtypes with adenylyl cyclase in the rat brain: a concentration-response study using forskolin.	2000 Apr	10704268

Patents

Sample Use Guides

In Vitro Use Guide

Flerobuterol is a beta1- and beta2-adrenoceptor agonist (Ki = 926 nM and 518 nM, respectively).

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:50:52 UTC 2023` Edited by `admin` on `Fri Dec 15 15:50:52 UTC 2023`
Record UNII	F05RR5M463
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLEROBUTEROL

Official Name

English

.ALPHA.-((TERT-BUTYLAMINO)METHYL)-O-FLUOROBENZYL ALCOHOL

Common Name

English

BENZENEMETHANOL, .ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-2-FLUORO-

Systematic Name

English

flerobuterol [INN]

Common Name

English

2-(TERT-BUTYLAMINO)-1-(2-FLUOROPHENYL)ETHAN-1-OL

Common Name

English

(±)-FLEROBUTEROL

Common Name

English

.ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-2-FLUOROBENZENEMETHANOL

Common Name

English

DL-FLEROBUTEROL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265