FLEROBUTEROL HYDROCHLORIDE

Cl.CC(C)(C)NCC(O)C1=C(F)C=CC=C1

InChIKey=NXNFXCMJTRKWFF-UHFFFAOYSA-N

InChI=1S/C12H18FNO.ClH/c1-12(2,3)14-8-11(15)9-6-4-5-7-10(9)13;/h4-7,11,14-15H,8H2,1-3H3;1H

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

FLEROBUTEROL is a beta-adrenoceptor agonist with potential antidepressant activity.

PubMed

Title	Date	PubMed
Effects of CRL 40827 and salbutamol on exocrine pancreatic secretion in rats.	1988 Jan 27	2895009
Flerobuterol, a beta-adrenoceptor agonist, enhances serotonergic neurotransmission: an electrophysiological study in the rat brain.	1991	1676181
Flerobuterol: a potential antidepressant drug related to beta-adrenergic agonists. Experimental profile in mice.	1991	1686009
Evidence for different interactions between beta(1)- and beta(2)-adrenoceptor subtypes with adenylyl cyclase in the rat brain: a concentration-response study using forskolin.	2000 Apr	10704268

Patents

In Vitro Use Guide

Flerobuterol is a beta1- and beta2-adrenoceptor agonist (Ki = 926 nM and 518 nM, respectively).

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:30:38 GMT 2023` Edited by `admin` on `Sat Dec 16 08:30:38 GMT 2023`
Record UNII	SC4AEV9EKY
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

FLEROBUTEROL HYDROCHLORIDE

Common Name

English

BENZENEMETHANOL, .ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-2-FLUORO-, HYDROCHLORIDE (1:1)

Systematic Name

English

CRL-40827

Code

English

BENZENEMETHANOL, .ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-2-FLUORO-, HYDROCHLORIDE

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID601002475