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Details

Stereochemistry UNKNOWN
Molecular Formula C12H18FNO
Molecular Weight 211.2758
Optical Activity ( - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLEROBUTEROL, (-)-

SMILES

CC(C)(C)NCC(O)C1=C(F)C=CC=C1

InChI

InChIKey=XTJMTDZHCLBKFU-UHFFFAOYSA-N
InChI=1S/C12H18FNO/c1-12(2,3)14-8-11(15)9-6-4-5-7-10(9)13/h4-7,11,14-15H,8H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C12H18FNO
Molecular Weight 211.2758
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

FLEROBUTEROL is a beta-adrenoceptor agonist with potential antidepressant activity.

CNS Activity

Curator's Comment: Known to be CNS active in rat. Human data not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Effects of CRL 40827 and salbutamol on exocrine pancreatic secretion in rats.
1988 Jan 27
Flerobuterol, a beta-adrenoceptor agonist, enhances serotonergic neurotransmission: an electrophysiological study in the rat brain.
1991
Flerobuterol: a potential antidepressant drug related to beta-adrenergic agonists. Experimental profile in mice.
1991
Evidence for different interactions between beta(1)- and beta(2)-adrenoceptor subtypes with adenylyl cyclase in the rat brain: a concentration-response study using forskolin.
2000 Apr
Patents

Patents

Sample Use Guides

In Vitro Use Guide
Flerobuterol is a beta1- and beta2-adrenoceptor agonist (Ki = 926 nM and 518 nM, respectively).
Substance Class Chemical
Created
by admin
on Fri Dec 15 20:23:20 GMT 2023
Edited
by admin
on Fri Dec 15 20:23:20 GMT 2023
Record UNII
65X4YX7X4F
Record Status Validated (UNII)
Record Version
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Name Type Language
FLEROBUTEROL, (-)-
Common Name English
L-FLEROBUTEROL
Common Name English
BENZENEMETHANOL, .ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-2-FLUORO-, (-)-
Systematic Name English
(-)-FLEROBUTEROL
Common Name English
(-)-.ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-2-FLUOROBENZENEMETHANOL
Common Name English
Code System Code Type Description
CAS
101687-91-6
Created by admin on Fri Dec 15 20:23:20 GMT 2023 , Edited by admin on Fri Dec 15 20:23:20 GMT 2023
PRIMARY
FDA UNII
65X4YX7X4F
Created by admin on Fri Dec 15 20:23:20 GMT 2023 , Edited by admin on Fri Dec 15 20:23:20 GMT 2023
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER
ENANTIOMER -> ENANTIOMER