U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry UNKNOWN
Molecular Formula C12H18FNO
Molecular Weight 211.2758
Optical Activity ( - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLEROBUTEROL, (-)-

SMILES

CC(C)(C)NCC(O)C1=CC=CC=C1F

InChI

InChIKey=XTJMTDZHCLBKFU-UHFFFAOYSA-N
InChI=1S/C12H18FNO/c1-12(2,3)14-8-11(15)9-6-4-5-7-10(9)13/h4-7,11,14-15H,8H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C12H18FNO
Molecular Weight 211.2758
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

FLEROBUTEROL is a beta-adrenoceptor agonist with potential antidepressant activity.

CNS Activity

Curator's Comment: Known to be CNS active in rat. Human data not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Evidence for different interactions between beta(1)- and beta(2)-adrenoceptor subtypes with adenylyl cyclase in the rat brain: a concentration-response study using forskolin.
2000-04
Flerobuterol, a beta-adrenoceptor agonist, enhances serotonergic neurotransmission: an electrophysiological study in the rat brain.
1991
Flerobuterol: a potential antidepressant drug related to beta-adrenergic agonists. Experimental profile in mice.
1991
Effects of CRL 40827 and salbutamol on exocrine pancreatic secretion in rats.
1988-01-27
Patents

Patents

Sample Use Guides

In Vitro Use Guide
Flerobuterol is a beta1- and beta2-adrenoceptor agonist (Ki = 926 nM and 518 nM, respectively).
Substance Class Chemical
Created
by admin
on Mon Mar 31 20:09:17 GMT 2025
Edited
by admin
on Mon Mar 31 20:09:17 GMT 2025
Record UNII
65X4YX7X4F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FLEROBUTEROL, (-)-
Common Name English
(-)-FLEROBUTEROL
Preferred Name English
L-FLEROBUTEROL
Common Name English
BENZENEMETHANOL, .ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-2-FLUORO-, (-)-
Systematic Name English
(-)-.ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-2-FLUOROBENZENEMETHANOL
Common Name English
Code System Code Type Description
CAS
101687-91-6
Created by admin on Mon Mar 31 20:09:17 GMT 2025 , Edited by admin on Mon Mar 31 20:09:17 GMT 2025
PRIMARY
FDA UNII
65X4YX7X4F
Created by admin on Mon Mar 31 20:09:17 GMT 2025 , Edited by admin on Mon Mar 31 20:09:17 GMT 2025
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER
ENANTIOMER -> ENANTIOMER