Egalognastat

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H21N5O3S
Molecular Weight	375.445
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H](N1CCN(CC1)C2=NN=C(NC(C)=O)S2)C3=CC=C4OCOC4=C3

InChI

InChIKey=PLUUAFJXXNCXSD-NSHDSACASA-N

InChI=1S/C17H21N5O3S/c1-11(13-3-4-14-15(9-13)25-10-24-14)21-5-7-22(8-6-21)17-20-19-16(26-17)18-12(2)23/h3-4,9,11H,5-8,10H2,1-2H3,(H,18,19,23)/t11-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C17H21N5O3S
Molecular Weight	375.445
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:00:34 GMT 2025` Edited by `admin` on `Wed Apr 02 08:00:34 GMT 2025`
Record UNII	E9QIS63WUM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

(S)-N-(5-(4-(1-(BENZO(D)(1,3)DIOXOL-5-YL)ETHYL)PIPERAZIN-1-YL)-1,3,4-THIA-DIAZOL-2-YL)ACETAMIDE

Preferred Name

English

Egalognastat

Official Name

English

ASN90

Code

English

ASN-561

Code

English

ASN561

Code

English

ASN-90

Code

English

ASN-120290

Common Name

English

egalognastat [INN]

Common Name

English

ACETAMIDE, N-(5-(4-((1S)-1-(1,3-BENZODIOXOL-5-YL)ETHYL)-1-PIPERAZINYL)-1,3,4-THIADIAZOL-2-YL)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

118903008

Created by admin on Wed Apr 02 08:00:34 GMT 2025 , Edited by admin on Wed Apr 02 08:00:34 GMT 2025

PRIMARY

SMS_ID

300000025419

Created by admin on Wed Apr 02 08:00:34 GMT 2025 , Edited by admin on Wed Apr 02 08:00:34 GMT 2025

PRIMARY

INN

13548

Created by admin on Wed Apr 02 08:00:34 GMT 2025 , Edited by admin on Wed Apr 02 08:00:34 GMT 2025

PRIMARY

FDA UNII

E9QIS63WUM

Created by admin on Wed Apr 02 08:00:34 GMT 2025 , Edited by admin on Wed Apr 02 08:00:34 GMT 2025

PRIMARY

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PROTEIN O-GLCNACASE

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Comments:

Human PBMC increase in O-glycans

Qualification:

EC50

Amount:


					QR9EFE0TG6

MICROTUBULE-ASSOCIATED PROTEIN TAU (PAIRED HELICAL FILAMENTS (PHF))

TARGET->INHIBITOR OF AGGREGATION

Comments:

Increases O-glycans on Tau protein that prevents aggregation

Amount:


					L9E2OD8XIY

ALPHA-SYNUCLEIN

TARGET->INHIBITOR OF AGGREGATION

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:

Related Record Type Details


					E9QIS63WUM

Egalognastat

ACTIVE MOIETY

Comments:

O-GlcNAcase enzyme inhibitor

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
BRAIN/PLASMA RATIO	PHARMACOKINETIC				Species BIOLOGICAL