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Approval Year

Unknown
139594
Substance Class Protein
Created
by admin
on Sat Dec 16 12:04:56 UTC 2023
Edited
by admin
on Sat Dec 16 12:04:56 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
D8T754TT2I
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
COX-2
Common Name English
PROSTAGLANDIN H2 SYNTHASE 2
Common Name English
PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2
Common Name English
COX2
Common Name English
CYCLOOXYGENASE-2
Common Name English
PTGS2
Common Name English
PROSTAGLANDIN G/H SYNTHASE 2
Common Name English
Code System Code Type Description
UNIPROT
P35354
Created by admin on Sat Dec 16 12:04:58 UTC 2023 , Edited by admin on Sat Dec 16 12:04:58 UTC 2023
PRIMARY
FDA UNII
D8T754TT2I
Created by admin on Sat Dec 16 12:04:58 UTC 2023 , Edited by admin on Sat Dec 16 12:04:58 UTC 2023
PRIMARY
From To
1_4 1_15
1_5 1_128
1_9 1_25
1_27 1_37
1_538 1_544
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_36
N 1_113
N 1_379
N 1_563
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INHIBITOR -> TARGET
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Structure of 2-((2,6-DICHLORO-3-(HYDROXYMETHYL)PHENYL)AMINO)BENZOIC ACID
INHIBITOR -> TARGET
Metabolite I, formed by hydroxylation of the methyl group, and its glucuronide conjugates accounted for 50 to 60 per cent of radioactivity in urine (approximately 35 per cent of dose). This metabolite possesses pharmacologic activity equal to one-fifth that of meclofenamic acid in an in vim system which measures inhibition of bovine seminal vesicle cyclo~xygenase.
Structure of LUMIRACOXIB
INHIBITOR -> TARGET
Structure of SULFASALAZINE
INHIBITOR -> TARGET
Structure of TEBUFELONE
INHIBITOR -> METABOLIC ENZYME
CHLORIDE CHANNEL PROTEIN CLC-KA
INHIBITOR -> TARGET
Structure of VALDECOXIB
INHIBITOR -> TARGET
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INHIBITOR -> TARGET
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Structure of CIMICOXIB
INHIBITOR -> TARGET
Selective used in small animals (dogs)
Structure of OCAROCOXIB
INHIBITOR -> TARGET
Structure of FLOSULIDE
INHIBITOR -> METABOLIC ENZYME
COTSIRANIB
INHIBITOR OF EXPRESSION->TARGET
Structure of MCI-C11
RADIOLIGAND->TARGET
Structure of MCI
MCI
INHIBITOR -> TARGET
IC50
LIXADESIRAN
INHIBITOR OF EXPRESSION->TARGET
Structure of OTENAPROXESUL
INHIBITOR -> TARGET
Structure of OXAPROZIN
INHIBITOR -> TARGET
Structure of DICLOFENAC
INHIBITOR -> TARGET
IC50
Structure of SEMAPIMOD
INHIBITOR -> TARGET
Structure of TILMACOXIB
INHIBITOR -> TARGET
Structure of TOLMETIN
INHIBITOR -> TARGET
Structure of FK-3311
INHIBITOR -> TARGET
Structure of BN-82451
INHIBITOR -> TARGET
IC50
Structure of POLMACOXIB
INHIBITOR -> TARGET
Structure of DARBUFELONE
INHIBITOR -> TARGET
Structure of ETORICOXIB
INHIBITOR -> TARGET
SELECTIVE
Structure of LICOFELONE
INHIBITOR -> TARGET
Structure of APRICOXIB
INHIBITOR -> TARGET
Structure of TAZOFELONE
INHIBITOR -> TARGET
Structure of SALSALATE
INHIBITOR -> TARGET
Structure of BALSALAZIDE
INHIBITOR -> TARGET
Structure of SC-236
INHIBITOR -> TARGET
Structure of ROFECOXIB
INHIBITOR -> TARGET
IC50
Structure of SULINDAC SULFIDE
INHIBITOR -> TARGET
Structure of CELECOXIB
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL
NIH
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