COX-2

Possibly Marketed Outside US

Approval Year

Substance Class	Protein Created by `admin` on `Thu Jul 06 17:41:31 UTC 2023` Edited by `admin` on `Thu Jul 06 17:41:31 UTC 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	D8T754TT2I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

COX-2

Common Name

English

PROSTAGLANDIN H2 SYNTHASE 2

Common Name

English

PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2

Common Name

English

CYCLOOXYGENASE-2

Common Name

English

PTGS2

Common Name

English

PROSTAGLANDIN G/H SYNTHASE 2

Common Name

English

Code System Code Type Description

FDA UNII

D8T754TT2I

Created by admin on Thu Jul 06 17:41:33 UTC 2023 , Edited by admin on Thu Jul 06 17:41:33 UTC 2023

PRIMARY

From	To
1_4	1_15
1_5	1_128
1_9	1_25
1_27	1_37
1_538	1_544

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_36
N	1_113
N	1_379
N	1_563

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Amount:


					GTG42NLU2Z

2-((2,6-DICHLORO-3-(HYDROXYMETHYL)PHENYL)AMINO)BENZOIC ACID

INHIBITOR -> TARGET

Comments:

Metabolite I, formed by hydroxylation of the methyl group, and its glucuronide conjugates accounted for 50 to 60 per cent of radioactivity in urine (approximately 35 per cent of dose). This metabolite possesses pharmacologic activity equal to one-fifth that of meclofenamic acid in an in vim system which measures inhibition of bovine seminal vesicle cyclo~xygenase.

Amount: