LIXADESIRAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Tue Apr 01 23:43:15 GMT 2025` Edited by `admin` on `Tue Apr 01 23:43:15 GMT 2025`
Nucleic Acid Type	RNAI
Sequence Type	COMPLETE
Record UNII	P3CNL1GL6K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LIXADESIRAN

Official Name

English

RNA, (A-C-A-U-C-A-U-C-A-G-A-C-C-A-G-G-C-A-C-C-A-G-A-C-C), COMPLEX WITH RNA (G-G-U-C-U-G-G-U-G-C-C-U-G-G-U-C-U-G-A-U-G-A-U-G-U) (1:1)

Preferred Name

English

STP-705 COMPONENT ANTI-COX2 SI-RNA FREE ACID

Common Name

English

lixadesiran [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C184815

Created by admin on Tue Apr 01 23:43:15 GMT 2025 , Edited by admin on Tue Apr 01 23:43:15 GMT 2025

PRIMARY

CAS

1152798-49-6

Created by admin on Tue Apr 01 23:43:15 GMT 2025 , Edited by admin on Tue Apr 01 23:43:15 GMT 2025

PRIMARY

FDA UNII

P3CNL1GL6K

Created by admin on Tue Apr 01 23:43:15 GMT 2025 , Edited by admin on Tue Apr 01 23:43:15 GMT 2025

PRIMARY

INN

11757

Created by admin on Tue Apr 01 23:43:15 GMT 2025 , Edited by admin on Tue Apr 01 23:43:15 GMT 2025

PRIMARY

SMS_ID

300000041909

Created by admin on Tue Apr 01 23:43:15 GMT 2025 , Edited by admin on Tue Apr 01 23:43:15 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_25;2_1-2_25	50 / 50

Linkage	Site Range	Site Count
Phosphate	1_2-1_25;2_2-2_25	48 / 48

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LIXADESIRAN SODIUM

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					D8T754TT2I

COX-2

TARGET->INHIBITOR OF EXPRESSION

Amount:

Related Record Type Details


					P3CNL1GL6K

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL