CIMICOXIB

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H13ClFN3O3S
Molecular Weight	381.809
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1F)C2=C(Cl)N=CN2C3=CC=C(C=C3)S(N)(=O)=O

InChI

InChIKey=KYXDNECMRLFQMZ-UHFFFAOYSA-N

InChI=1S/C16H13ClFN3O3S/c1-24-14-7-2-10(8-13(14)18)15-16(17)20-9-21(15)11-3-5-12(6-4-11)25(19,22)23/h2-9H,1H3,(H2,19,22,23)

HIDE SMILES / InChI

Molecular Formula	C16H13ClFN3O3S
Molecular Weight	381.809
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/29166275 | https://www.ncbi.nlm.nih.gov/pubmed/29716837 | https://www.ncbi.nlm.nih.gov/pubmed/30521538

Cimicoxib is a selective cyclooxygenase 2 inhibitor used in veterinary medicine to treat dogs for pain and inflammation associated with osteoarthritis and for the management of pain and inflammation associated with surgery. Limited data are available on cimicoxib, with one study documenting non-inferiority compared to carprofen in managing postoperative pain for dogs undergoing either orthopedic or soft tissue surgery. There are some data available as part of cimicoxib’s approval process in Europe to support its use for chronic pain.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclooxygenase-2 201 Target ID: CHEMBL230 Sources: http://ec.europa.eu/health/documents/community-register/2016/20160107133569/anx_133569_en.pdf	Inhibitor 8504		0.1 µM [IC50]
Cyclooxygenase-1 131 Target ID: CHEMBL221 Sources: http://ec.europa.eu/health/documents/community-register/2016/20160107133569/anx_133569_en.pdf	Inhibitor 8504		1.9 µM [IC50]

PubMed

Title	Date	PubMed
New water-soluble sulfonylphosphoramidic acid derivatives of the COX-2 selective inhibitor cimicoxib. A novel approach to sulfonamide prodrugs.	2004 Oct 21	15481993

Sample Use Guides

In Vivo Use Guide

Dog 2mg/kg Sheep 4-6mg/kg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:20:24 GMT 2025` Edited by `admin` on `Mon Mar 31 18:20:24 GMT 2025`
Record UNII	W7FHJ107MC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CIMICOXIB

Official Name

English

CIMALGEX

Preferred Name

English

CIMICOXIB [MI]

Common Name

English

cimicoxib [INN]

Common Name

English

UR-8880

Code

English

4-(4-CHLORO-5-(3-FLUORO-4-METHOXYPHENYL)-1H-IMIDAZOL-1-YL)BENZENESULFONAMIDE

Systematic Name

English

CIMICOXIB (EMA EPAR: VETERINARY)

Common Name

English

Classification Tree Code System Code

WHO-VATC

QM01AH93