Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.4351 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C(=O)CCCC#C
InChI
InChIKey=ZHXUEUKVDMWSKV-UHFFFAOYSA-N
InChI=1S/C20H28O2/c1-8-9-10-11-17(21)14-12-15(19(2,3)4)18(22)16(13-14)20(5,6)7/h1,12-13,22H,9-11H2,2-7H3
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.4351 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Tebufelone (formerly NE-11740) is a member of the di-tert-butyl-phenol anti-inflammatory agents. Tebufelone is a dual cyclooxygenase (CO)/5-lipoxygenase (LO) inhibitor that has potent analgesic, antipyretic, and anti-inflammatory effects. This drug was studied for the treatment of rheumatic disorders; however, this study was discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Long-term performance of a gas chromatography/tandem mass spectrometry assay for tebufelone in plasma. | 1990 Sep 1 |
|
| Antipyretic activity of tebufelone (NE-11740) in man. | 1991 |
|
| Transcription, translation and secretion of interleukin 1 and tumor necrosis factor: effects of tebufelone, a dual cyclooxygenase/5-lipoxygenase inhibitor. | 1991 Feb |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:31:14 UTC 2023
by
admin
on
Fri Dec 15 15:31:14 UTC 2023
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| Record UNII |
O048K9ZFHO
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| Record Status |
Validated (UNII)
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NCI_THESAURUS |
C257
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60542
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C152522
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100000082455
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AA-25
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CHEMBL13878
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| Related Record | Type | Details | ||
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METABOLIC ENZYME -> INHIBITOR | |||
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TARGET -> INHIBITOR |
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ACTIVE MOIETY |
