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Details

Stereochemistry ACHIRAL
Molecular Formula C20H28O2
Molecular Weight 300.4351
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TEBUFELONE

SMILES

CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C(=O)CCCC#C

InChI

InChIKey=ZHXUEUKVDMWSKV-UHFFFAOYSA-N
InChI=1S/C20H28O2/c1-8-9-10-11-17(21)14-12-15(19(2,3)4)18(22)16(13-14)20(5,6)7/h1,12-13,22H,9-11H2,2-7H3

HIDE SMILES / InChI

Molecular Formula C20H28O2
Molecular Weight 300.4351
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Tebufelone (formerly NE-11740) is a member of the di-tert-butyl-phenol anti-inflammatory agents. Tebufelone is a dual cyclooxygenase (CO)/5-lipoxygenase (LO) inhibitor that has potent analgesic, antipyretic, and anti-inflammatory effects. This drug was studied for the treatment of rheumatic disorders; however, this study was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Determination of leukotriene B4 in human plasma by gas chromatography using a mass selective detector and a stable isotope labelled internal standard. Effect of NE-11740 on arachidonic acid metabolism.
1990
Transcription, translation and secretion of interleukin 1 and tumor necrosis factor: effects of tebufelone, a dual cyclooxygenase/5-lipoxygenase inhibitor.
1991 Feb

Sample Use Guides

Subjects received a single peroral dose of placebo, 650 mg aspirin (ASA), or tebufelone at doses of 25, 50, 100, or 200 mg.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:59:49 GMT 2025
Edited
by admin
on Mon Mar 31 17:59:49 GMT 2025
Record UNII
O048K9ZFHO
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NE 11740
Preferred Name English
TEBUFELONE
INN   USAN  
USAN   INN  
Official Name English
NE-11740
Code English
TEBUFELONE [USAN]
Common Name English
tebufelone [INN]
Common Name English
5-HEXYN-1-ONE, 1-(3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL)-
Systematic Name English
3',5'-DI-TERT-BUTYL-4'-HYDROXY-5-HEXYNOPHENONE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Mon Mar 31 17:59:49 GMT 2025 , Edited by admin on Mon Mar 31 17:59:49 GMT 2025
Code System Code Type Description
FDA UNII
O048K9ZFHO
Created by admin on Mon Mar 31 17:59:49 GMT 2025 , Edited by admin on Mon Mar 31 17:59:49 GMT 2025
PRIMARY
EVMPD
SUB10854MIG
Created by admin on Mon Mar 31 17:59:49 GMT 2025 , Edited by admin on Mon Mar 31 17:59:49 GMT 2025
PRIMARY
INN
6601
Created by admin on Mon Mar 31 17:59:49 GMT 2025 , Edited by admin on Mon Mar 31 17:59:49 GMT 2025
PRIMARY
EPA CompTox
DTXSID10149818
Created by admin on Mon Mar 31 17:59:49 GMT 2025 , Edited by admin on Mon Mar 31 17:59:49 GMT 2025
PRIMARY
CAS
112018-00-5
Created by admin on Mon Mar 31 17:59:49 GMT 2025 , Edited by admin on Mon Mar 31 17:59:49 GMT 2025
PRIMARY
PUBCHEM
60542
Created by admin on Mon Mar 31 17:59:49 GMT 2025 , Edited by admin on Mon Mar 31 17:59:49 GMT 2025
PRIMARY
NCI_THESAURUS
C152522
Created by admin on Mon Mar 31 17:59:49 GMT 2025 , Edited by admin on Mon Mar 31 17:59:49 GMT 2025
PRIMARY
SMS_ID
100000082455
Created by admin on Mon Mar 31 17:59:49 GMT 2025 , Edited by admin on Mon Mar 31 17:59:49 GMT 2025
PRIMARY
USAN
AA-25
Created by admin on Mon Mar 31 17:59:49 GMT 2025 , Edited by admin on Mon Mar 31 17:59:49 GMT 2025
PRIMARY
ChEMBL
CHEMBL13878
Created by admin on Mon Mar 31 17:59:49 GMT 2025 , Edited by admin on Mon Mar 31 17:59:49 GMT 2025
PRIMARY
Related Record Type Details
METABOLIC ENZYME -> INHIBITOR
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY