Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H11NO2 |
| Molecular Weight | 105.1356 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCCNCCO
InChI
InChIKey=ZBCBWPMODOFKDW-UHFFFAOYSA-N
InChI=1S/C4H11NO2/c6-3-1-5-2-4-7/h5-7H,1-4H2
| Molecular Formula | C4H11NO2 |
| Molecular Weight | 105.1356 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Diethanolamine (DEA) is an amino alcohol commonly used in the preparation of soaps and surfactants, agricultural chemicals and in textile processing. DEA and DEA-Derivatives are used in other products besides cosmetics and personal care products. For example, DEA and DEA-derivatives have been approved for several food-related applications, primarily food packaging.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| NTP Toxicology and Carcinogenesis Studies of Diethanolamine (CAS No. 111-42-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies). | 1999 Jul |
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| Toxicology and carcinogenesis studies of coconut oil acid diethanolamine condensate (CAS No. 68603-42-9) in F344/N rats and B6C3F1 mice (dermal studies). | 2001 Jan |
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| Tritosylate of diethanolamine. | 2001 Mar |
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| Evaluation of the impurity profile of alcuronium by means of capillary electrophoresis. | 2002 Jun 1 |
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| The unusually high proton affinity of aza-18-crown-6 ether: implications for the molecular recognition of lysine in peptides by lariat crown ethers. | 2002 May |
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| Low-volume jet injection for intradermal immunization in rabbits. | 2002 May 23 |
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| The effect of different buffers and amounts of intestinal alkaline phosphatase isoforms on total alkaline phosphatase activity. | 2002 May 7 |
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| Local anaesthetic effects and toxicity of seven new diethanolamine and morpholine derivatives of fomocaine. Testing in rats compared with procaine and tetracaine. | 2003 |
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| Percentage of the positive area of bone metastasis is an independent predictor of disease death in advanced prostate cancer. | 2003 Jan 27 |
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| A new stressed test to predict the foreign matter formation of minodronic acid in solution. | 2003 Jan 30 |
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| [Separation of carbon dioxide from gas mixture by membrane contactor]. | 2003 Sep |
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| An adapted ELISA method for differentiating pathogenic from nonpathogenic aPL by a beta 2 glycoprotein I dependency anticardiolipin assay. | 2004 |
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| Determination of alkanolamines in cattails (Typha latifolia) utilizing electrospray ionization with selected reaction monitoring and ion-exchange chromatography. | 2004 |
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| Development of a fully buffered molybdate electrolyte for capillary electrophoresis with indirect detection and its use for analysis of anions in Bayer liquor. | 2004 Feb |
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| Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines. | 2004 Jan |
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| Theoretical scales of hydrogen bond acidity and basicity for application in QSAR/QSPR studies and drug design. Partitioning of aliphatic compounds. | 2004 May-Jun |
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| Assembling novel heterotrimetallic Cu/Co/Ni and Cu/Co/Cd cores supported by diethanolamine ligand in one-pot reactions of zerovalent copper with metal salts. | 2004 Nov 29 |
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| In vitro human skin penetration of diethanolamine. | 2004 Oct |
|
| Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG). | 2004 Sep |
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| Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram. | 2005 Jan 21 |
|
| Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005 Jun |
|
| Simultaneous detection of monoethanolamine, diethanolamine, and triethanolamine by HPLC with a chemiluminescence reaction and online derivatization to tertiary amine. | 2005 May |
|
| Small-angle neutron scattering of ionic perfluoropolyether micellar solutions: role of counterions and temperature. | 2005 May 12 |
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| Species differences in the induction of hepatocellular DNA synthesis by diethanolamine. | 2005 Oct |
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| Investigation of the formation of N-nitrosodiethanolamine in B6C3F1 mice following topical administration of triethanolamine. | 2005 Oct |
|
| Stimulating effect of Japanese herbal (kampo) medicine, hochuekkito on upper respiratory mucosal immune system. | 2006 Dec |
|
| Cloning, functional expression and primary characterization of Vibrio parahaemolyticus K+/H+ antiporter genes in Escherichia coli. | 2006 Jan |
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| Potassium/proton antiport system of Escherichia coli. | 2006 Jul 21 |
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| Chemical exposures. Will DEA findings wash? | 2006 Nov |
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| Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells. | 2007 Apr |
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| hnRNP E1 and E2 have distinct roles in modulating HIV-1 gene expression. | 2007 Apr 23 |
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| Regenerating fuel-gas desulfurizing agents by using bipolar membrane electrodialysis (BMED): effect of molecular structure of alkanolamines on the regeneration performance. | 2007 Feb 1 |
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| CO2 absorption in aqueous solutions of alkanolamines: mechanistic insight from quantum chemical calculations. | 2007 Feb 22 |
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| DEA in consumer products is safe. | 2007 Jan |
|
| Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. | 2007 Jan 18 |
|
| Determination of occupational exposure to alkanolamines in metal-working fluids. | 2007 Mar |
|
| Biodegradation of novel amino acid derivatives suitable for complexing agents in pulp bleaching applications. | 2007 May 1 |
Patents
Sample Use Guides
MICE: Groups of 50 male and 50 female mice were administered 0, 40, 80, or 160 mg diethanolamine/kg body weight in ethanol dermally for 2 years. In male mice, the incidences of hepatocellular adenoma and of hepatocellular adenoma or carcinoma (combined) in all dosed groups and of hepatocellular carcinoma and hepatoblastoma in 80 and 160 mg/kg males were significantly increased compared to the vehicle controls.
Route of Administration:
Other
Sperm suspension was incubated with different concentrations (100–500 ug/mL) of diethanolamine to evaluate sperm parameters such as sperm motility, sperm viability and sperm morphology. diethanolamine caused significant decrease in sperm motility and sperm viability which was concentration and time–dependent.
| Substance Class |
Chemical
Created
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admin
on
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Sat Dec 16 17:01:42 GMT 2023
by
admin
on
Sat Dec 16 17:01:42 GMT 2023
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| Record UNII |
AZE05TDV2V
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Validated (UNII)
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CFR |
21 CFR 176.170
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C020283
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DIETHANOLAMINE
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