Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H11NO2 |
| Molecular Weight | 105.1356 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCCNCCO
InChI
InChIKey=ZBCBWPMODOFKDW-UHFFFAOYSA-N
InChI=1S/C4H11NO2/c6-3-1-5-2-4-7/h5-7H,1-4H2
| Molecular Formula | C4H11NO2 |
| Molecular Weight | 105.1356 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Diethanolamine (DEA) is an amino alcohol commonly used in the preparation of soaps and surfactants, agricultural chemicals and in textile processing. DEA and DEA-Derivatives are used in other products besides cosmetics and personal care products. For example, DEA and DEA-derivatives have been approved for several food-related applications, primarily food packaging.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The effect of ovary implants on juvenile hormone production by corpora allata of male Diploptera punctata. | 2003 |
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| Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen. | 2003 Dec 18 |
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| [Separation of carbon dioxide from gas mixture by membrane contactor]. | 2003 Sep |
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| [Assessment of the emission of volatile organic compounds from polyurethane foams]. | 2004 |
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| Determination of alkanolamines in cattails (Typha latifolia) utilizing electrospray ionization with selected reaction monitoring and ion-exchange chromatography. | 2004 |
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| Bystander suppression of collagen-induced arthritis in mice fed ovalbumin. | 2004 |
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| IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways. | 2004 |
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| Synthesis, structure, and dynamics of six-membered metallacoronands and metallodendrimers of iron and indium. | 2004 Apr 19 |
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| Development of a fully buffered molybdate electrolyte for capillary electrophoresis with indirect detection and its use for analysis of anions in Bayer liquor. | 2004 Feb |
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| Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas. | 2004 Feb 9 |
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| Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines. | 2004 Jan |
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| Expanding the vision of environmental health at UNC-CH. | 2004 Jul |
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| Theoretical scales of hydrogen bond acidity and basicity for application in QSAR/QSPR studies and drug design. Partitioning of aliphatic compounds. | 2004 May-Jun |
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| In vitro human skin penetration of diethanolamine. | 2004 Oct |
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| Determination of volatile corrosion inhibitors by capillary electrophoresis. | 2004 Oct 8 |
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| A functional variant of Fcgamma receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies. | 2005 |
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| Chemical-induced atrial thrombosis in NTP rodent studies. | 2005 |
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| Elevated matrix metalloproteinase-9 in patients with systemic sclerosis. | 2005 |
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| Chemical destabilization of oil-in-water emulsion by novel polymerized diethanolamines. | 2005 Apr 1 |
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| Review of the carcinogenic activity of diethanolamine and evidence of choline deficiency as a plausible mode of action. | 2005 Dec |
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| Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram. | 2005 Jan 21 |
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| Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005 Jun |
|
| Determination of diethanolamine in shampoo products containing fatty acid diethanolamides by liquid chromatography with a thermal energy analyzer. | 2005 Mar-Apr |
|
| Simultaneous detection of monoethanolamine, diethanolamine, and triethanolamine by HPLC with a chemiluminescence reaction and online derivatization to tertiary amine. | 2005 May |
|
| Percutaneous penetration of diethanolamine through human skin in vitro: application from cosmetic vehicles. | 2005 May |
|
| Small-angle neutron scattering of ionic perfluoropolyether micellar solutions: role of counterions and temperature. | 2005 May 12 |
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| Effect of cationic micellar aggregates on the kinetics of oxidation of aminoalcohols by N-bromosuccinimide in alkaline medium. | 2005 May 15 |
|
| Determination of novel complexing agents in pulp and paper mill effluents and in lake water by liquid chromatography. | 2005 Nov 11 |
|
| Ecotoxicological evaluation of diethanolamine using a battery of microbiotests. | 2005 Oct |
|
| P5L mutation in Ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced ATDC5 cells. | 2006 |
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| Impairment of chondrocyte biosynthetic activity by exposure to 3-tesla high-field magnetic resonance imaging is temporary. | 2006 |
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| Diethanolamine and phenobarbital produce an altered pattern of methylation in GC-rich regions of DNA in B6C3F1 mouse hepatocytes similar to that resulting from choline deficiency. | 2006 Apr |
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| Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus. | 2006 Aug |
|
| Stimulating effect of Japanese herbal (kampo) medicine, hochuekkito on upper respiratory mucosal immune system. | 2006 Dec |
|
| The decay of the ATPase activity of light plus thiol-activated thylakoid membranes in the dark. | 2006 Feb |
|
| Potassium/proton antiport system of Escherichia coli. | 2006 Jul 21 |
|
| A heterotrimetallic Cu-Co-Zn complex with the 2,2'-iminodiethanol ligand. | 2006 Jun |
|
| Chemical exposures. Will DEA findings wash? | 2006 Nov |
|
| Synthesis, structure, and hydrolytic reaction of trans-dichlorobis(diethanolamine-N)palladium(II) with N-acetylated L-histidylglycine dipeptide. | 2006 Oct |
|
| Simultaneous absorption of CO2 and H2S into aqueous blends of N-methyldiethanolamine and diethanolamine. | 2006 Oct 1 |
|
| Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells. | 2007 Apr |
|
| hnRNP E1 and E2 have distinct roles in modulating HIV-1 gene expression. | 2007 Apr 23 |
|
| Regenerating fuel-gas desulfurizing agents by using bipolar membrane electrodialysis (BMED): effect of molecular structure of alkanolamines on the regeneration performance. | 2007 Feb 1 |
|
| CO2 absorption in aqueous solutions of alkanolamines: mechanistic insight from quantum chemical calculations. | 2007 Feb 22 |
|
| DEA in consumer products is safe. | 2007 Jan |
|
| Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. | 2007 Jan 18 |
|
| Ternary complexes of flurbiprofen with HP-beta-CD and ethanolamines characterization and transdermal delivery. | 2007 Mar |
|
| Determination of occupational exposure to alkanolamines in metal-working fluids. | 2007 Mar |
|
| Repeated dose toxicity and developmental toxicity of diisopropanolamine to rats. | 2007 Oct |
|
| Use of high-boiling point organic solvents for pulping oil palm empty fruit bunches. | 2008 Apr |
Patents
Sample Use Guides
MICE: Groups of 50 male and 50 female mice were administered 0, 40, 80, or 160 mg diethanolamine/kg body weight in ethanol dermally for 2 years. In male mice, the incidences of hepatocellular adenoma and of hepatocellular adenoma or carcinoma (combined) in all dosed groups and of hepatocellular carcinoma and hepatoblastoma in 80 and 160 mg/kg males were significantly increased compared to the vehicle controls.
Route of Administration:
Other
Sperm suspension was incubated with different concentrations (100–500 ug/mL) of diethanolamine to evaluate sperm parameters such as sperm motility, sperm viability and sperm morphology. diethanolamine caused significant decrease in sperm motility and sperm viability which was concentration and time–dependent.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:01:42 GMT 2023
by
admin
on
Sat Dec 16 17:01:42 GMT 2023
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| Record UNII |
AZE05TDV2V
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| Record Status |
Validated (UNII)
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CFR |
21 CFR 176.170
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C020283
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DIETHANOLAMINE
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