Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C11H13N3O3S.C4H11NO2 |
| Molecular Weight | 372.44 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCCNCCO.CC1=NOC(NS(=O)(=O)C2=CC=C(N)C=C2)=C1C
InChI
InChIKey=FEPTXVIRMZIGFY-UHFFFAOYSA-N
InChI=1S/C11H13N3O3S.C4H11NO2/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10;6-3-1-5-2-4-7/h3-6,14H,12H2,1-2H3;5-7H,1-4H2
| Molecular Formula | C11H13N3O3S |
| Molecular Weight | 267.304 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C4H11NO2 |
| Molecular Weight | 105.1356 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Diethanolamine (DEA) is an amino alcohol commonly used in the preparation of soaps and surfactants, agricultural chemicals and in textile processing. DEA and DEA-Derivatives are used in other products besides cosmetics and personal care products. For example, DEA and DEA-derivatives have been approved for several food-related applications, primarily food packaging.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The effect of ovary implants on juvenile hormone production by corpora allata of male Diploptera punctata. | 2003 |
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| An adapted ELISA method for differentiating pathogenic from nonpathogenic aPL by a beta 2 glycoprotein I dependency anticardiolipin assay. | 2004 |
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| [Assessment of the emission of volatile organic compounds from polyurethane foams]. | 2004 |
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| Determination of alkanolamines in cattails (Typha latifolia) utilizing electrospray ionization with selected reaction monitoring and ion-exchange chromatography. | 2004 |
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| Theoretical scales of hydrogen bond acidity and basicity for application in QSAR/QSPR studies and drug design. Partitioning of aliphatic compounds. | 2004 May-Jun |
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| Assembling novel heterotrimetallic Cu/Co/Ni and Cu/Co/Cd cores supported by diethanolamine ligand in one-pot reactions of zerovalent copper with metal salts. | 2004 Nov 29 |
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| Determination of volatile corrosion inhibitors by capillary electrophoresis. | 2004 Oct 8 |
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| Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG). | 2004 Sep |
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| Determination of diethanolamine or N-methyldiethanolamine in high ammonium concentration matrices by capillary electrophoresis with indirect UV detection: application to the analysis of refinery process waters. | 2004 Sep |
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| A functional variant of Fcgamma receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies. | 2005 |
|
| Chemical-induced atrial thrombosis in NTP rodent studies. | 2005 |
|
| Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as predictors of severe outcomes in patients with recent-onset polyarthritis. | 2005 |
|
| Evaluation of alkaline phosphatase activity assay for the Reflotron system after substitution of the comparison method. | 2005 |
|
| Elevated matrix metalloproteinase-9 in patients with systemic sclerosis. | 2005 |
|
| Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis. | 2005 |
|
| Chemical destabilization of oil-in-water emulsion by novel polymerized diethanolamines. | 2005 Apr 1 |
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| Simultaneous determination of inorganic anions and organic acids in amine solutions for sour gas treatment by capillary electrophoresis with indirect UV detection. | 2005 Dec 30 |
|
| Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram. | 2005 Jan 21 |
|
| High-frequency, high-field EPR; magnetic susceptibility; and X-ray studies on a ferromagnetic heterometallic complex of diethanolamine (H2L), [Cu4(NH3)4(HL)4][CdBr4]Br2.3dmf.H2O. | 2005 Jan 24 |
|
| Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005 Jun |
|
| Determination of diethanolamine in shampoo products containing fatty acid diethanolamides by liquid chromatography with a thermal energy analyzer. | 2005 Mar-Apr |
|
| Percutaneous penetration of diethanolamine through human skin in vitro: application from cosmetic vehicles. | 2005 May |
|
| Small-angle neutron scattering of ionic perfluoropolyether micellar solutions: role of counterions and temperature. | 2005 May 12 |
|
| Effect of cationic micellar aggregates on the kinetics of oxidation of aminoalcohols by N-bromosuccinimide in alkaline medium. | 2005 May 15 |
|
| Ecotoxicological evaluation of diethanolamine using a battery of microbiotests. | 2005 Oct |
|
| Species differences in the induction of hepatocellular DNA synthesis by diethanolamine. | 2005 Oct |
|
| Investigation of the formation of N-nitrosodiethanolamine in B6C3F1 mice following topical administration of triethanolamine. | 2005 Oct |
|
| Mechanistic explanation to the catalysis by pyrazinamide and ethambutol of reaction between rifampicin and isoniazid in anti-TB FDCs. | 2005 Oct 4 |
|
| P5L mutation in Ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced ATDC5 cells. | 2006 |
|
| Impairment of chondrocyte biosynthetic activity by exposure to 3-tesla high-field magnetic resonance imaging is temporary. | 2006 |
|
| Diethanolamine and phenobarbital produce an altered pattern of methylation in GC-rich regions of DNA in B6C3F1 mouse hepatocytes similar to that resulting from choline deficiency. | 2006 Apr |
|
| Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus. | 2006 Aug |
|
| Stimulating effect of Japanese herbal (kampo) medicine, hochuekkito on upper respiratory mucosal immune system. | 2006 Dec |
|
| The decay of the ATPase activity of light plus thiol-activated thylakoid membranes in the dark. | 2006 Feb |
|
| Cloning, functional expression and primary characterization of Vibrio parahaemolyticus K+/H+ antiporter genes in Escherichia coli. | 2006 Jan |
|
| Chemical exposures. Will DEA findings wash? | 2006 Nov |
|
| Synthesis, structure, and hydrolytic reaction of trans-dichlorobis(diethanolamine-N)palladium(II) with N-acetylated L-histidylglycine dipeptide. | 2006 Oct |
|
| Simultaneous absorption of CO2 and H2S into aqueous blends of N-methyldiethanolamine and diethanolamine. | 2006 Oct 1 |
|
| Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells. | 2007 Apr |
|
| hnRNP E1 and E2 have distinct roles in modulating HIV-1 gene expression. | 2007 Apr 23 |
|
| Regenerating fuel-gas desulfurizing agents by using bipolar membrane electrodialysis (BMED): effect of molecular structure of alkanolamines on the regeneration performance. | 2007 Feb 1 |
|
| CO2 absorption in aqueous solutions of alkanolamines: mechanistic insight from quantum chemical calculations. | 2007 Feb 22 |
|
| DEA in consumer products is safe. | 2007 Jan |
|
| Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. | 2007 Jan 18 |
|
| Simultaneous monitoring of inorganic cations, amines and amino acids in human sweat by capillary electrophoresis. | 2007 Jan 2 |
|
| Ternary complexes of flurbiprofen with HP-beta-CD and ethanolamines characterization and transdermal delivery. | 2007 Mar |
|
| Determination of occupational exposure to alkanolamines in metal-working fluids. | 2007 Mar |
|
| Biodegradation of novel amino acid derivatives suitable for complexing agents in pulp bleaching applications. | 2007 May 1 |
|
| Repeated dose toxicity and developmental toxicity of diisopropanolamine to rats. | 2007 Oct |
|
| Use of high-boiling point organic solvents for pulping oil palm empty fruit bunches. | 2008 Apr |
Patents
Sample Use Guides
MICE: Groups of 50 male and 50 female mice were administered 0, 40, 80, or 160 mg diethanolamine/kg body weight in ethanol dermally for 2 years. In male mice, the incidences of hepatocellular adenoma and of hepatocellular adenoma or carcinoma (combined) in all dosed groups and of hepatocellular carcinoma and hepatoblastoma in 80 and 160 mg/kg males were significantly increased compared to the vehicle controls.
Route of Administration:
Other
Sperm suspension was incubated with different concentrations (100–500 ug/mL) of diethanolamine to evaluate sperm parameters such as sperm motility, sperm viability and sperm morphology. diethanolamine caused significant decrease in sperm motility and sperm viability which was concentration and time–dependent.
| Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 14:58:30 GMT 2023
by
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on
Fri Dec 15 14:58:30 GMT 2023
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| Record UNII |
30S4B46J8B
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| Record Status |
Validated (UNII)
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C29739
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ACTIVE MOIETY |