IODOPYRACET

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H5I2NO3.C4H11NO2
Molecular Weight	510.0641
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCNCCO.OC(=O)CN1C=C(I)C(=O)C(I)=C1

InChI

InChIKey=RERHJVNYJKZHLJ-UHFFFAOYSA-N

InChI=1S/C7H5I2NO3.C4H11NO2/c8-4-1-10(3-6(11)12)2-5(9)7(4)13;6-3-1-5-2-4-7/h1-2H,3H2,(H,11,12);5-7H,1-4H2

HIDE SMILES / InChI

Molecular Formula	C7H5I2NO3
Molecular Weight	404.9284
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C4H11NO2
Molecular Weight	105.1356
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13648987 | https://www.ncbi.nlm.nih.gov/pubmed/26819427 | https://www.ncbi.nlm.nih.gov/pubmed/2374087 |

Iodopyracet (Diodone) is a radiocontrast agent used in urography before 1950. Renal clearance of iodopyracet is characterized by supply-limited elimination at low plasma concentrations and capacity-limited elimination at high plasma levels. Iodopyracet to be an effective agent for the estimation of renal plasma flow and tubular function has been used extensively in physiological studies. In 1945 was found, that p-aminohippuric acid was in some ways superior to diodone for these estimations in man because the urine and plasma blanks are small and because diodone penetrates human red blood cells whereas p-aminohippuric acid does not.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Solute carrier family 22 member 6 19 Target ID: CHEMBL1777665 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14734677	Substrate 661

Doses

Dose	Population	Adverse events
10 g single, intravenous Dose: 10 g Route: intravenous Route: single Dose: 10 g Co-administed with:: diphenhydramine(20 mg) Sources: https://pubmed.ncbi.nlm.nih.gov/13057637/	unhealthy n = 416 Health Status: unhealthy Condition: urography Population Size: 416 Sources: https://pubmed.ncbi.nlm.nih.gov/13057637/	Other AEs: Nausea and vomiting, Urticaria... Other AEs: Nausea and vomiting (severe, 2 patients) Urticaria (8 patients) Sleepiness (34 patients) Sources: https://pubmed.ncbi.nlm.nih.gov/13057637/

AEs

AE	Significance	Dose	Population
Sleepiness	34 patients	10 g single, intravenous Dose: 10 g Route: intravenous Route: single Dose: 10 g Co-administed with:: diphenhydramine(20 mg) Sources: https://pubmed.ncbi.nlm.nih.gov/13057637/	unhealthy n = 416 Health Status: unhealthy Condition: urography Population Size: 416 Sources: https://pubmed.ncbi.nlm.nih.gov/13057637/
Urticaria	8 patients	10 g single, intravenous Dose: 10 g Route: intravenous Route: single Dose: 10 g Co-administed with:: diphenhydramine(20 mg) Sources: https://pubmed.ncbi.nlm.nih.gov/13057637/	unhealthy n = 416 Health Status: unhealthy Condition: urography Population Size: 416 Sources: https://pubmed.ncbi.nlm.nih.gov/13057637/
Nausea and vomiting	severe, 2 patients	10 g single, intravenous Dose: 10 g Route: intravenous Route: single Dose: 10 g Co-administed with:: diphenhydramine(20 mg) Sources: https://pubmed.ncbi.nlm.nih.gov/13057637/	unhealthy n = 416 Health Status: unhealthy Condition: urography Population Size: 416 Sources: https://pubmed.ncbi.nlm.nih.gov/13057637/

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-029640	http://www.3bsc.com/index/pro_info.php?id=50897
AHH Chemical co.,ltd	MT-09966	http://www.ahhchemical.com/product/MT-09966.html
AK Scientific, Inc. (AKSCI)	7334AC	http://www.aksci.com/item_detail.php?cat=7334AC
Aaron Chemicals	AR00044K	http://www.aaronchem.com/101-29-1
Achemica	ACMC-2097ut	http://www.achemica.com/prodinfo/?id=118546
Alfa Aesar	B25646	https://www.alfa.com/en/catalog/B25646/
Alichem	29188758	http://www.alichem.com/en/products/101-29-1.html
Alinda	ALBB-012849	http://alinda.ru/finechem_en_.html?i=ALBB-012849
Ambeed	A210327	https://www.ambeed.com/products/101-29-1.html
Ambinter	Amb19650727	http://www.ambinter.com/reference/19650727
Angel Pharmatech	AG191998	http://www.angelpharmatech.com/101-29-1.html
Anward	ANW-14451	http://www.anward.com/pro_result/13602
Aurora Fine Chemicals LLC	K00.366.054	http://online.aurorafinechemicals.com/info?ID=K00.366.054
Aurum Pharmatech LLC	X-4136	http://www.Aurumpharmatech.com/Product/ProductDetails/X_4136
Avantor Inc	TCD1763-025G	https://us.vwr.com/store/product/10049063/3-5-diiodo-4-pyridone-1-acetic-acid-98-0-by-hplc-titration-analysis
BLD Pharm	BD82701	http://www.bldpharm.com/products/101-29-1.html
Chemspace	CSSB00000210907	https://chem-space.com/CSSB00000210907
Enamine	Z220383428	https://www.enaminestore.com/catalog/Z220383428
Finetech	FT-0627271	http://www.finetechnology-ind.com/prod/detail/pub/101-29-1.html
Iodochem	ID2986	https://www.iodochem.com/product/101-29-1
Lab Network	LN00162917	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00162917
Matrix Scientific	63036	https://www.matrixscientific.com/063036.html
Parchem	37269	https://www.parchem.com/chemical-supplier-distributor/3-5-Diiodo-4-pyridone-1-acetic-acid-037269.aspx
Sigma-Aldrich	R751073_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/r751073
Smolecule	S566634	https://www.smolecule.com/products/s566634
TCI (Tokyo Chemical Industry)	D1763	http://www.tcichemicals.com/eshop/en/us/commodity/D1763/index.html
abcr GmbH	AB141901	http://www.abcr.com/shop/en/AB141901
eNovation Chemicals	D123028	https://www.enovationchem.com/ProductDetails.asp?ProductID=D123028
mcule	MCULE-6565498896	https://mcule.com/MCULE-6565498896/

PubMed

Title	Date	PubMed
A clinical evaluation of the iodopyracet (diodrast) renogram.	1959 Jun	13648987

Sample Use Guides

In Vivo Use Guide

3.0 g, administered i.v.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:49:43 GMT 2023` Edited by `admin` on `Sat Dec 16 15:49:43 GMT 2023`
Record UNII	ZTK4026YJ5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IODOPYRACET

Common Name

English

Diodone [WHO-DD]

Common Name

English

IODOPYRACET [MI]

Common Name

English

diodone [INN]

Common Name

English

DIODONE

Official Name

English

DIODRAST

Brand Name

English

CARDIOTRAST

Brand Name

English

3,5-DIIODO-4-OXO-1-(4H)-PYRIDINEACETIC ACID 2,2'-IMINODIETHANOL (1:1) COMPOUND

Common Name

English

DIODONE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28500