DIETHANOLAMINE FUSIDATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C31H48O6.C4H11NO2
Molecular Weight	621.8449
Optical Activity	UNSPECIFIED
Defined Stereocenters	10 / 10
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCNCCO.[H][C@@]12C[C@@H](O)[C@@]3([H])[C@@]4(C)CC[C@@H](O)[C@@H](C)[C@]4([H])CC[C@]3(C)[C@@]1(C)C[C@H](OC(C)=O)\C2=C(\CCC=C(C)C)C(O)=O

InChI

InChIKey=OQZZCXRLEFBPLZ-JCJNLNMISA-N

InChI=1S/C31H48O6.C4H11NO2/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32;6-3-1-5-2-4-7/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36);5-7H,1-4H2/b26-20-;/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C31H48O6
Molecular Weight	516.7092
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 10
E/Z Centers	1
Optical Activity	UNSPECIFIED

Molecular Formula	C4H11NO2
Molecular Weight	105.1356
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Haematuria during methicillin therapy.	1971 Jul	5560145
Protein synthesis in Mycobacterium tuberculosis H37Rv and the effect of streptomycin in streptomycin-susceptible and -resistant strains.	1973 Sep	4202339
Adverse reactions to intravenous administration of fusidic acid.	1981	7244561
Staphylococcal septicaemia complicated by probable cloxacillin neurotoxicity and by jaundice induced by fusidic acid.	1983 Apr	6867701
Screening for new compounds with antiherpes activity.	1984 Oct	6517562
Fusidic acid-induced hyperbilirubinemia.	1987 Aug	3608735
Inhibition of HIV replication in vitro by fusidic acid.	1987 Oct 10	2443777
Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin.	1992 Aug	1420741
Acute renal failure following intravenous fusidic acid.	1993	8394548
Acute renal failure in association with fusidic acid.	1997 Jun	9287276
Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium.	1997 May	9145860
In vitro susceptibility of Mycobacterium tuberculosis to fusidic acid.	2001 Dec	11843915
Antimycobacterial plant terpenoids.	2001 Nov	11731906
Hypocalcaemia during fusidic acid therapy.	2002 Feb	11823554
Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate.	2002 Jul 1	12106615
[Cholestatic icterus induced by the administration of fusidic acid in a cirrhotic patient].	2002 Jun 29	12148265
Sideroblastic anaemia during fusidic acid treatment.	2004 May	15059072
Linezolid for the treatment of patients with endocarditis: a systematic review of the published evidence.	2006 Aug	16735427
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.	2010 Dec	20829430
Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).	2013 Dec	24014644

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 20:31:41 GMT 2023` Edited by `admin` on `Fri Dec 15 20:31:41 GMT 2023`
Record UNII	1XKK7J9CT6
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DIETHANOLAMINE FUSIDATE

Common Name

English

FUSIDATE DIOLAMINE

Common Name

English

29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID, 16-(ACETYLOXY)-3,11-DIHYDROXY-, (3.ALPHA.,4.ALPHA.,8.ALPHA.,9.ALPHA.,11.ALPHA.,13.ALPHA.,14.BETA.,16.BETA.,17Z)-, COMPD. WITH 2,2'-IMINOBIS(ETHANOL) (1:1)

Common Name

English

FUSIDATE DIETHANOLAMINE

Common Name

English

Diethanolamine fusidate [WHO-DD]

Common Name

English

Code System Code Type Description

SMS_ID

100000079554