Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C31H48O6.C4H11NO2 |
| Molecular Weight | 621.8449 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCCNCCO.[H][C@@]12C[C@@H](O)[C@@]3([H])[C@@]4(C)CC[C@@H](O)[C@@H](C)[C@]4([H])CC[C@]3(C)[C@@]1(C)C[C@H](OC(C)=O)\C2=C(\CCC=C(C)C)C(O)=O
InChI
InChIKey=OQZZCXRLEFBPLZ-JCJNLNMISA-N
InChI=1S/C31H48O6.C4H11NO2/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32;6-3-1-5-2-4-7/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36);5-7H,1-4H2/b26-20-;/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-;/m0./s1
| Molecular Formula | C31H48O6 |
| Molecular Weight | 516.7092 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | C4H11NO2 |
| Molecular Weight | 105.1356 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Haematuria during methicillin therapy. | 1971 Jul |
|
| Protein synthesis in Mycobacterium tuberculosis H37Rv and the effect of streptomycin in streptomycin-susceptible and -resistant strains. | 1973 Sep |
|
| Adverse reactions to intravenous administration of fusidic acid. | 1981 |
|
| Staphylococcal septicaemia complicated by probable cloxacillin neurotoxicity and by jaundice induced by fusidic acid. | 1983 Apr |
|
| Screening for new compounds with antiherpes activity. | 1984 Oct |
|
| Fusidic acid-induced hyperbilirubinemia. | 1987 Aug |
|
| Inhibition of HIV replication in vitro by fusidic acid. | 1987 Oct 10 |
|
| Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. | 1989 Jan |
|
| Suppression of HIV replication in vitro by fusidic acid parallels cell toxicity. | 1989 Jan |
|
| Comparative in-vitro activities of ten fluoroquinolones and fusidic acid against Mycobacterium spp. | 1990 Sep |
|
| Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin. | 1992 Aug |
|
| Acute renal failure following intravenous fusidic acid. | 1993 |
|
| Anti-HIV activity of dideoxynucleosides, foscarnet and fusidic acid is potentiated by human leukocyte interferon in blood-derived macrophages. | 1994 May-Jun |
|
| Acute renal failure in association with fusidic acid. | 1997 Jun |
|
| Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. | 1997 May |
|
| In vitro susceptibility of Mycobacterium tuberculosis to fusidic acid. | 2001 Dec |
|
| Antimycobacterial plant terpenoids. | 2001 Nov |
|
| Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype and revertant strains. | 2009 Apr |
|
| Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). | 2013 Dec |
|
| Canine ocular thelaziosis caused by Thelazia callipaeda in Portugal. | 2013 Jul |
|
| A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. | 2013 Nov |
|
| Fusidic acid is an effective treatment against Toxoplasma gondii and Listeria monocytogenes in vitro, but not in mice. | 2013 Nov |
|
| A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. | 2014 Jan |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 20:31:41 GMT 2023
by
admin
on
Fri Dec 15 20:31:41 GMT 2023
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| Record UNII |
1XKK7J9CT6
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| Record Status |
Validated (UNII)
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| Record Version |
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100000079554
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1XKK7J9CT6
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240-442-3
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SUB13572MIG
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C013483
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16391-75-6
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46174083
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DTXSID701020012
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22971
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE | |||
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PARENT -> SALT/SOLVATE |
