U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CH4N2O
Molecular Weight 60.0553
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of UREA

SMILES

NC(N)=O

InChI

InChIKey=XSQUKJJJFZCRTK-UHFFFAOYSA-N
InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

HIDE SMILES / InChI

Molecular Formula CH4N2O
Molecular Weight 60.0553
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Pastaron (Urea) is a waste product of many living organisms, and is the major organic component of human urine. It is a very important starting material in a number of chemical syntheses, and is used on an industrial scale for the manufacture of fertilizers, pharmaceuticals, and resins. Urea is an osmotic diuretic similar to mannitol but more irritant. Applied topically, urea promotes hydration of keratin and mild keratolysis in dry skin. It increases water uptake by the stratum corneum and has an antipruritic effect. Pastaron is used to soften rough or dry skin caused by skin conditions such as eczema, psoriasis, keratosis, and others.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
UREAPHIL

Approved Use

Pastaron is used topically to treat hyperkeratotic conditions such as dry, rough skin, ichthyosis (rough, thick, and scaly skin), skin cracks and fissures, dermatitis (inflammation of skin), eczema, psoriasis, keratosis (rough, scaly patch on skin) and calluses (hard and thickened area on skin, especially hands or feet).

Launch Date

-1.15171197E11
Palliative
UREAPHIL

Approved Use

Pastaron is used topically to treat hyperkeratotic conditions such as dry, rough skin, ichthyosis (rough, thick, and scaly skin), skin cracks and fissures, dermatitis (inflammation of skin), eczema, psoriasis, keratosis (rough, scaly patch on skin) and calluses (hard and thickened area on skin, especially hands or feet).

Launch Date

-1.02384001E11
Palliative
UREAPHIL

Approved Use

Pastaron is used topically to treat hyperkeratotic conditions such as dry, rough skin, ichthyosis (rough, thick, and scaly skin), skin cracks and fissures, dermatitis (inflammation of skin), eczema, psoriasis, keratosis (rough, scaly patch on skin) and calluses (hard and thickened area on skin, especially hands or feet).

Launch Date

-1.15171197E11
PubMed

PubMed

TitleDatePubMed
Biosynthesis of biotin and lipoic acid.
2001
Role of nitric oxide in the synthesis of guanidinosuccinic acid, an activator of the N-methyl-D-aspartate receptor.
2001 Feb
Increased reduction of dimethylarginines and lowered interdialytic blood pressure by the use of biocompatible membranes.
2001 Feb
Increasing dialysate flow rate increases dialyzer urea mass transfer-area coefficients during clinical use.
2001 Feb
Evaluation of serological markers for the immunodiagnosis of acute acquired toxoplasmosis.
2001 Jan
Long-term correction of urea cycle disorders.
2001 Jan
Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight.
2001 Jan
Creatine supplementation increases renal disease progression in Han:SPRD-cy rats.
2001 Jan
Ornithine carbamoyltransferase deficiency.
2001 Jan
Effects of acute and chronic hypertension on the labyrinthine barriers in rat.
2001 Jan
Does the antitumor cyclopropylpyrroloindole antibiotic CC-1065 cross-link DNA in tumor cells?
2001 Jan 1
Conformational origin of the aggregation of recombinant human factor VIII.
2001 Jan 16
Predicting the kinetics of peptide-antibody interactions using a multivariate experimental design of sequence and chemical space.
2001 Jan-Feb
The impact of urea on viscosity of hydroxethyl cellulose and observed mobility of deoxyribonucleic acids.
2001 Mar
High hydrostatic pressure can probe the effects of functionally related ligands on the quaternary structures of the chaperonins GroEL and GroES.
2001 Mar 2
The metastable state of nucleocapsids of enveloped viruses as probed by high hydrostatic pressure.
2001 Mar 9
Patents

Sample Use Guides

Applied to the affected area one or several times a day.
Route of Administration: Topical
Endometrial explants were cultured and treated with 0, 4, 8, 12, 16 mM of urea. Relative FGF2 gene expression was less in explants treated with a greater concentration of urea (16mM) when compared with lesser concentrations. Expression of HSPA1A, IGFBP3, and SERPINA14 genes was greater in explants exposed to lesser concentrations of urea (4mM). Greater concentrations of urea have negative effects on some endometrial gene expression, while moderate concentrations have positive effects.
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:32:54 UTC 2023
Edited
by admin
on Wed Jul 05 22:32:54 UTC 2023
Record UNII
8W8T17847W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
UREA
EP   FCC   HPUS   HSDB   II   INCI   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
INCI  
Official Name English
UREA [USP IMPURITY]
Common Name English
UREA [MART.]
Common Name English
INS NO.927A
Code English
UREA COMPONENT OF CALMURID HC
Common Name English
CALMURID HC COMPONENT UREA
Common Name English
UREA [USP MONOGRAPH]
Common Name English
UREA COMPONENT OF U-CORT
Common Name English
U-CORT COMPONENT UREA
Common Name English
AZODICARBOXYLIC ACID-DIAMIDE
Common Name English
UREA [II]
Common Name English
UREA [EP MONOGRAPH]
Common Name English
UREA [VANDF]
Common Name English
UREA COMPONENT OF CARMOL HC
Common Name English
AZOBISFORMAMIDE
Systematic Name English
INS-927A
Code English
UREA [INCI]
Common Name English
UREA COMPONENT OF ALPHADERM
Common Name English
UREA [ORANGE BOOK]
Common Name English
CARMOL HC COMPONENT UREA
Common Name English
ALLANTOIN IMPURITY B [EP IMPURITY]
Common Name English
UREA [FCC]
Common Name English
ALPHADERM COMPONENT UREA
Common Name English
UREA [HSDB]
Common Name English
E-927A
Code English
FLUOROURACIL IMPURITY G [EP IMPURITY]
Common Name English
UREA [MI]
Common Name English
UREA [USP-RS]
Common Name English
UREA [JAN]
Common Name English
UREA [HPUS]
Common Name English
NSC-34375
Code English
Carbamide
Common Name English
Urea [WHO-DD]
Common Name English
Classification Tree Code System Code
LOINC 39781-0
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LOINC 12266-3
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CODEX ALIMENTARIUS (GSFA) E-927A
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LOINC 47708-3
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LOINC 12974-2
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FDA ORPHAN DRUG 192204
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LOINC 72926-9
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NCI_THESAURUS C49187
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FDA ORPHAN DRUG 346211
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LOINC 47798-4
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WHO-VATC QD02AE51
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LOINC 25998-6
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EPA PESTICIDE CODE 85702
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LOINC 39780-2
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DSLD 3894 (Number of products:6)
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JECFA EVALUATION E-927A
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CFR 21 CFR 310.538
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WHO-ATC D02AE01
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WHO-VATC QD02AE01
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LOINC 23786-7
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CFR 21 CFR 184.1923
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WHO-ATC B05BC02
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LOINC 12267-1
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CFR 21 CFR 310.527
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LOINC 53137-6
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WHO-ESSENTIAL MEDICINES LIST 13.4
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LOINC 72903-8
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Code System Code Type Description
EPA CompTox
DTXSID4021426
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
RXCUI
11002
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY RxNorm
DRUG BANK
DB03904
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
RS_ITEM_NUM
1706698
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
SMS_ID
100000091977
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
MESH
D014508
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
EVMPD
SUB15662MIG
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
WIKIPEDIA
Urea-containing cream
Created by admin on Wed Jul 05 22:32:55 UTC 2023 , Edited by admin on Wed Jul 05 22:32:55 UTC 2023
PRIMARY
CHEBI
16199
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
ChEMBL
CHEMBL985
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
WIKIPEDIA
UREA
Created by admin on Wed Jul 05 22:32:55 UTC 2023 , Edited by admin on Wed Jul 05 22:32:55 UTC 2023
PRIMARY
PUBCHEM
1176
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
DAILYMED
8W8T17847W
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
NCI_THESAURUS
C29531
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
CAS
57-13-6
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
NSC
34375
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
HSDB
163
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-315-5
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
DRUG CENTRAL
4264
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
FDA UNII
8W8T17847W
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
MERCK INDEX
M11322
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY Merck Index
JECFA MONOGRAPH
E-927A
Created by admin on Wed Jul 05 22:32:54 UTC 2023 , Edited by admin on Wed Jul 05 22:32:54 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
Related Record Type Details
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (TLC)
EP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
ACTIVE MOIETY