U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Cu
Molecular Weight 63.546
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of CUPRIC CATION

SMILES

[Cu++]

InChI

InChIKey=JPVYNHNXODAKFH-UHFFFAOYSA-N
InChI=1S/Cu/q+2

HIDE SMILES / InChI

Molecular Formula Cu
Molecular Weight 63.546
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: http://fs1.agrian.com/pdfs/CORE_7.5_Copper_EDTA_Label.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/24106015 | https://www.ncbi.nlm.nih.gov/pubmed/20942456http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013010.pdfhttp://www.drugfuture.com/chemdata/tetraamminecopper-sulfate.html | https://cameochemicals.noaa.gov/chemical/3026https://www.ncbi.nlm.nih.gov/pubmed/6526221https://www.ncbi.nlm.nih.gov/pubmed/16971307https://www3.epa.gov/pesticides/chem_search/ppls/019713-00509-20110705.pdfhttps://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.518 | http://www.worldofchemicals.com/chemicals/chemical-properties/cupric-glycinate.htmlDOI: 10.1107/s0567740869001725 Retrived from http://scripts.iucr.org/cgi-bin/paper?S0567740869001725https://www.ncbi.nlm.nih.gov/pubmed/15704330 | https://www.ncbi.nlm.nih.gov/pubmed/12425037 | https://www.ncbi.nlm.nih.gov/pubmed/1599240 | http://www.certisusa.com/pdf-labels/Kocide3000_label.pdf | http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33524https://www.ncbi.nlm.nih.gov/pubmed/8556785 | https://www.ncbi.nlm.nih.gov/pubmed/2135524http://www.emdmillipore.com/US/en/product/Copper-di-ammonium-Titriplex-solution,MDA_CHEM-105217https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a84d61a4-8e7f-4be1-aba6-f633b334aafc | http://www.sciencedirect.com/science/article/pii/S0167488912000158http://www.drugfuture.com/chemdata/schweizer-s-reagent.html | http://pubs.acs.org/doi/abs/10.1021/ed062p878?journalCode=jceda8 | http://pubs.acs.org/doi/abs/10.1021/ed019p356
Curator's Comment: description was created based on several sources, including: https://brandt.co/media/3786/09006mnr100_mineral-research_copper-count-n_lbl_2012-12_25g.pdf | https://southernag.com/wp-content/uploads/2014/06/southernag.com_docs_labels_msds_Liq-Copper-Gal.pdf

Tetraamminecopper dihydroxide also known as Schweizer's Reagent dissolves cellulose; used in rayon production.

CNS Activity

Curator's Comment: Cupric ion was shown to cross the blood brain barrier in rats.

Originator

Sources: http://pubs.acs.org/doi/abs/10.1021/ja01512a012Schweizer, J. Prakt. Chem. 72, 109, 344 (1857).
Curator's Comment: http://www.drugfuture.com/chemdata/schweizer-s-reagent.html

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
3.42 µM [Ki]
Target ID: P00450
Gene ID: 1356.0
Gene Symbol: CP
Target Organism: Homo sapiens (Human)
Target ID: Glutathione S-transferase, rat, liver
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Preventing
Cupric glycinate

Approved Use

Indications for use. For beef calves and beef cattle for the prevention of copper deficiency, or when labeled for veterinary prescription use, for the prevention and/or treatment of copper deficiency alone or in association with molybdenum toxicity.
Primary
COPPER•MAX

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Diagnostic
Unknown

Approved Use

Unknown
Preventing
COPPER

Approved Use

Copper 0.4 mg/mL (Cupric Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain copper serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Preventing
COPINOX

Approved Use

Copinox 4g is indicated for the prevention and treatment of copper deficiency in cattle and sheep.
PubMed

PubMed

TitleDatePubMed
Determination of protein by the biuret reaction using cupric hydroxide suspension reagent.
1960
Efficacy of burning, tillage, and biocides in controlling bacteria released at field sites and effects on indigenous bacteria and fungi.
1992 Apr
The genetics of tasting in mice. VII. Glycine revisited, and the chromosomal location of Sac and Soa.
1995 Oct
Bioavailability of copper from copper glycinate in steers fed high dietary sulfur and molybdenum.
2008 Jan
Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells.
2009 Oct
Generation of oxidant response to copper and iron nanoparticles and salts: Stimulation by ascorbate.
2009 Oct 30
Copper-promoted coupling of vinyl boronates and alcohols: a mild synthesis of allyl vinyl ethers.
2010 Feb 3
A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy.
2010 Nov 3
Anti-ovulatory activity of H2 receptor blockers in albino rabbits--a preliminary study.
2011 Apr
Molecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis.
2011 Dec 27
Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.
2012 Apr
Design, synthesis, antioxidant, and anti-breast cancer activities of novel diethyl(alkyl/aryl/heteroarylamino)(4-(pyridin-2-yl)phenyl)methylphosphonates.
2013 May
Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses.
2013 Nov
Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells.
2014 Jul
Electron induced surface reactions of organometallic metal(hfac)₂ precursors and deposit purification.
2014 Jun 11
CuO nanoparticles induce apoptosis by impairing the antioxidant defense and detoxification systems in the mouse hippocampal HT22 cell line: protective effect of crocetin.
2015 Jun
Dissecting copper homeostasis in diabetes mellitus.
2017 Apr
Roles of Copper-Binding Proteins in Breast Cancer.
2017 Apr 20
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Veterinary drug
Administer ONLY by subcutaneous (under the skin) injection. These doses may be repeated at a minimum period of every 4 months. Dosage may be increased to 4mL in cattle only when either clinical signs or laboratory testing has confirmed copper deficiency is severe. Cattle over 4 months 2mL (0.5 mg calcium copper edetate) Adult Sheep 1mL (0.25 mg calcium copper edetate) Deer 1mL (0.25 mg calcium copper edetate) per 50kg bodyweight
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:58:22 UTC 2023
Edited
by admin
on Wed Jul 05 22:58:22 UTC 2023
Record UNII
8CBV67279L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CUPRIC CATION
Common Name English
COPPER, ION (CU2+)
Common Name English
COPPER(II) ION
Common Name English
COPPER(II) CATION
Common Name English
CUPRIC ION
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C68249
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
FDA ORPHAN DRUG 771520
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
Code System Code Type Description
CAS
15158-11-9
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
DAILYMED
8CBV67279L
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
RXCUI
1427198
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID40934294
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
PUBCHEM
27099
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
SMS_ID
100000087380
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
CHEBI
29036
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
NCI_THESAURUS
C68251
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
FDA UNII
8CBV67279L
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
DRUG BANK
DB09130
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
LIGAND->TARGET
Scientific Literature
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY