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Details

Stereochemistry ACHIRAL
Molecular Formula Cu
Molecular Weight 63.546
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of CUPRIC CATION

SMILES

[Cu++]

InChI

InChIKey=JPVYNHNXODAKFH-UHFFFAOYSA-N
InChI=1S/Cu/q+2

HIDE SMILES / InChI

Molecular Formula Cu
Molecular Weight 63.546
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.518 | http://www.worldofchemicals.com/chemicals/chemical-properties/cupric-glycinate.htmlhttps://www.ncbi.nlm.nih.gov/pubmed/8556785 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/15704330 | https://www.ncbi.nlm.nih.gov/pubmed/12425037 | https://www.ncbi.nlm.nih.gov/pubmed/1599240 | http://www.certisusa.com/pdf-labels/Kocide3000_label.pdf | http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33524http://www.emdmillipore.com/US/en/product/Copper-di-ammonium-Titriplex-solution,MDA_CHEM-105217https://www.ncbi.nlm.nih.gov/pubmed/16971307DOI: 10.1107/s0567740869001725 Retrived from http://scripts.iucr.org/cgi-bin/paper?S0567740869001725http://www.drugfuture.com/chemdata/tetraamminecopper-sulfate.html | https://cameochemicals.noaa.gov/chemical/3026https://www3.epa.gov/pesticides/chem_search/ppls/019713-00509-20110705.pdfhttp://fs1.agrian.com/pdfs/CORE_7.5_Copper_EDTA_Label.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/6526221http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013010.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/24106015 | https://www.ncbi.nlm.nih.gov/pubmed/20942456https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a84d61a4-8e7f-4be1-aba6-f633b334aafc | http://www.sciencedirect.com/science/article/pii/S0167488912000158http://www.drugfuture.com/chemdata/schweizer-s-reagent.html | http://pubs.acs.org/doi/abs/10.1021/ed062p878?journalCode=jceda8 | http://pubs.acs.org/doi/abs/10.1021/ed019p356
Curator's Comment: description was created based on several sources, including https://www.copper.org/resources/properties/compounds/other_compounds.html | http://www.vitamins-supplements.org/dietary-minerals/copper.php | https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=bea888b4-9cc6-49da-89e6-5c273b974ed1

Tetraamminecopper dihydroxide also known as Schweizer's Reagent dissolves cellulose; used in rayon production.

CNS Activity

Curator's Comment: Cupric ion was shown to cross the blood brain barrier in rats.

Originator

Sources: http://pubs.acs.org/doi/abs/10.1021/ja01512a012Schweizer, J. Prakt. Chem. 72, 109, 344 (1857).
Curator's Comment: http://www.drugfuture.com/chemdata/schweizer-s-reagent.html

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
3.42 µM [Ki]
Target ID: P00450
Gene ID: 1356.0
Gene Symbol: CP
Target Organism: Homo sapiens (Human)
Target ID: Glutathione S-transferase, rat, liver
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Preventing
Cupric glycinate

Approved Use

Indications for use. For beef calves and beef cattle for the prevention of copper deficiency, or when labeled for veterinary prescription use, for the prevention and/or treatment of copper deficiency alone or in association with molybdenum toxicity.
Primary
COPPER•MAX

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Diagnostic
Unknown

Approved Use

Unknown
Preventing
COPPER

Approved Use

Copper 0.4 mg/mL (Cupric Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain copper serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Preventing
COPINOX

Approved Use

Copinox 4g is indicated for the prevention and treatment of copper deficiency in cattle and sheep.
PubMed

PubMed

TitleDatePubMed
Determination of protein by the biuret reaction using cupric hydroxide suspension reagent.
1960
The effectiveness of ecologically acceptable ways of protection of field-grown tomato (Lycopersicon lycopersicum (L.) Karsten) from tomato late blight (Phytophthora infestans (Mont.) de Bary) in extreme weather conditions.
2001
Cu(II) acetate- and Mn(III) acetate-mediated radical reactions of [60]fullerene with ketonic compounds.
2005 Mar 7
Acute copper toxicity following copper glycinate injection.
2006 Nov
Enhanced copper release from pipes by alternating stagnation and flow events.
2007 Nov 1
Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide.
2008 Nov 1
Copper(II) acetate-catalyzed addition of arylboronic acids to aromatic aldehydes.
2009 Jan 16
Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells.
2009 Oct
Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.
2012 Apr
Probing the chemical nature of dihydrogen complexation to transition metals, a gas phase case study: H2-CuF.
2013 Jan 18
Design, synthesis, antioxidant, and anti-breast cancer activities of novel diethyl(alkyl/aryl/heteroarylamino)(4-(pyridin-2-yl)phenyl)methylphosphonates.
2013 May
Cytotoxicity in the age of nano: the role of fourth period transition metal oxide nanoparticle physicochemical properties.
2013 Nov 25
Electron induced surface reactions of organometallic metal(hfac)₂ precursors and deposit purification.
2014 Jun 11
A Facile Strategy for Catalyst Separation and Recycling Suitable for ATRP of Hydrophilic Monomers Using a Macroligand.
2016 Jan
Unusual 4-arsonoanilinium cationic species in the hydrochloride salt of (4-aminophenyl)arsonic acid and formed in the reaction of the acid with copper(II) sulfate, copper(II) chloride and cadmium chloride.
2017 Apr 1
Supplementation with copper edetate in control of Haemonchus contortus of sheep, and its effect on cholinesterase's and superoxide dismutase activities.
2017 Feb
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Veterinary drug
Healthy middle aged adults with moderately high cholesterol, were given either placebo or copper supplementation (2 mg copper/day as copper glycinate) for 8 weeks.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:58:22 UTC 2023
Edited
by admin
on Wed Jul 05 22:58:22 UTC 2023
Record UNII
8CBV67279L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CUPRIC CATION
Common Name English
COPPER, ION (CU2+)
Common Name English
COPPER(II) ION
Common Name English
COPPER(II) CATION
Common Name English
CUPRIC ION
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C68249
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
FDA ORPHAN DRUG 771520
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
Code System Code Type Description
CAS
15158-11-9
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
DAILYMED
8CBV67279L
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
RXCUI
1427198
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID40934294
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
PUBCHEM
27099
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
SMS_ID
100000087380
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
CHEBI
29036
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
NCI_THESAURUS
C68251
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
FDA UNII
8CBV67279L
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
DRUG BANK
DB09130
Created by admin on Wed Jul 05 22:58:22 UTC 2023 , Edited by admin on Wed Jul 05 22:58:22 UTC 2023
PRIMARY
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