U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2Cl.Cu.2H2O
Molecular Weight 170.483
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CUPRIC CHLORIDE

SMILES

O.O.[Cl-].[Cl-].[Cu++]

InChI

InChIKey=MPTQRFCYZCXJFQ-UHFFFAOYSA-L
InChI=1S/2ClH.Cu.2H2O/h2*1H;;2*1H2/q;;+2;;/p-2

HIDE SMILES / InChI

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Cu
Molecular Weight 63.546
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a84d61a4-8e7f-4be1-aba6-f633b334aafc | http://www.sciencedirect.com/science/article/pii/S0167488912000158https://www.ncbi.nlm.nih.gov/pubmed/16971307DOI: 10.1107/s0567740869001725 Retrived from http://scripts.iucr.org/cgi-bin/paper?S0567740869001725https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.518 | http://www.worldofchemicals.com/chemicals/chemical-properties/cupric-glycinate.htmlhttps://www.ncbi.nlm.nih.gov/pubmed/8556785 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.ncbi.nlm.nih.gov/pubmed/15704330 | https://www.ncbi.nlm.nih.gov/pubmed/12425037 | https://www.ncbi.nlm.nih.gov/pubmed/1599240 | http://www.certisusa.com/pdf-labels/Kocide3000_label.pdf | http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33524http://www.emdmillipore.com/US/en/product/Copper-di-ammonium-Titriplex-solution,MDA_CHEM-105217http://www.drugfuture.com/chemdata/tetraamminecopper-sulfate.html | https://cameochemicals.noaa.gov/chemical/3026https://www3.epa.gov/pesticides/chem_search/ppls/019713-00509-20110705.pdfhttp://fs1.agrian.com/pdfs/CORE_7.5_Copper_EDTA_Label.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/6526221http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013010.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/24106015 | https://www.ncbi.nlm.nih.gov/pubmed/20942456http://www.drugfuture.com/chemdata/schweizer-s-reagent.html | http://pubs.acs.org/doi/abs/10.1021/ed062p878?journalCode=jceda8 | http://pubs.acs.org/doi/abs/10.1021/ed019p356
Curator's Comment: description was created based on several sources, including https://www.copper.org/resources/properties/compounds/other_compounds.html | http://www.vitamins-supplements.org/dietary-minerals/copper.php | https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=bea888b4-9cc6-49da-89e6-5c273b974ed1

Tetraamminecopper dihydroxide also known as Schweizer's Reagent dissolves cellulose; used in rayon production.

CNS Activity

Curator's Comment: Known to be CNS active in zebrafish. Human data not available.

Originator

Sources: http://pubs.acs.org/doi/abs/10.1021/ja01512a012Schweizer, J. Prakt. Chem. 72, 109, 344 (1857).
Curator's Comment: http://www.drugfuture.com/chemdata/schweizer-s-reagent.html

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Preventing
Cupric glycinate

Approved Use

Indications for use. For beef calves and beef cattle for the prevention of copper deficiency, or when labeled for veterinary prescription use, for the prevention and/or treatment of copper deficiency alone or in association with molybdenum toxicity.
Primary
COPPER•MAX

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Diagnostic
Unknown

Approved Use

Unknown
Preventing
COPPER

Approved Use

Copper 0.4 mg/mL (Cupric Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain copper serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Preventing
COPINOX

Approved Use

Copinox 4g is indicated for the prevention and treatment of copper deficiency in cattle and sheep.
PubMed

PubMed

TitleDatePubMed
Determination of protein by the biuret reaction using cupric hydroxide suspension reagent.
1960
Copper Fluoride Luminescence during UV Photofragmentation of Bis(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)copper(II) in the Gas Phase.
1996 Aug 14
Direct catalytic aldol-type reactions using RCH2CN.
2003 Aug 21
Antioxidant activity of olive pulp and olive oil phenolic compounds of the arbequina cultivar.
2005 Mar 23
A spectroscopic and thermoanalytical study of the mineral hoganite.
2007 May
Enhanced copper release from pipes by alternating stagnation and flow events.
2007 Nov 1
Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide.
2008 Nov 1
Copper(II) acetate-catalyzed addition of arylboronic acids to aromatic aldehydes.
2009 Jan 16
Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells.
2009 Oct
Generation of oxidant response to copper and iron nanoparticles and salts: Stimulation by ascorbate.
2009 Oct 30
Copper-promoted coupling of vinyl boronates and alcohols: a mild synthesis of allyl vinyl ethers.
2010 Feb 3
Regulation of plasminogen activator inhibitor-1 expression in endothelial cells with exposure to metal nanoparticles.
2010 May 19
Molecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis.
2011 Dec 27
Rapid free chlorine decay in the presence of Cu(OH)2: chemistry and practical implications.
2011 Oct 15
Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.
2012 Apr
Protective effect of sulphoraphane against oxidative stress mediated toxicity induced by CuO nanoparticles in mouse embryonic fibroblasts BALB 3T3.
2012 Feb
Probing the chemical nature of dihydrogen complexation to transition metals, a gas phase case study: H2-CuF.
2013 Jan 18
Design, synthesis, antioxidant, and anti-breast cancer activities of novel diethyl(alkyl/aryl/heteroarylamino)(4-(pyridin-2-yl)phenyl)methylphosphonates.
2013 May
Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses.
2013 Nov
Cytotoxicity in the age of nano: the role of fourth period transition metal oxide nanoparticle physicochemical properties.
2013 Nov 25
Dissecting copper homeostasis in diabetes mellitus.
2017 Apr
Unusual 4-arsonoanilinium cationic species in the hydrochloride salt of (4-aminophenyl)arsonic acid and formed in the reaction of the acid with copper(II) sulfate, copper(II) chloride and cadmium chloride.
2017 Apr 1
Supplementation with copper edetate in control of Haemonchus contortus of sheep, and its effect on cholinesterase's and superoxide dismutase activities.
2017 Feb
Ultrasonic energy enhanced the efficiency of advance extraction methodology for enrichment of trace level of copper in serum samples of patients having neurological disorders.
2017 Jul
Comparison of the efficacy of a commercial footbath product with copper sulfate for the control of digital dermatitis.
2017 Jul
Folic acid-modified and functionalized CuS nanocrystal-based nanoparticles for combined tumor chemo- and photothermal therapy.
2017 Jun
Amino acid-mediated 'turn-off/turn-on' nanozyme activity of gold nanoclusters for sensitive and selective detection of copper ions and histidine.
2017 Jun 15
Effects of Excess Copper Ions on Decidualization of Human Endometrial Stromal Cells.
2017 May
Patents

Sample Use Guides

In Vivo Use Guide
Copper 0.4 mg/mL (Cupric Chloride Injection) contains 0.4 mg copper/mL and is administered intravenously only after dilution. The additive should be diluted in a volume of fluid not less than 100 mL. For the adult receiving total parenteral nutrition, the suggested additive dosage is 0.5 to 1.5 mg copper/day (1.25 to 3.75 mL/day). For pediatric patients, the suggested additive dosage is 20 mcg copper/kg/day (0.05 mL/kg/day). Infants weighing less than 1500 gm may have increased requirements because of their low body reserves and increased requirements for growth.
Route of Administration: Intravenous
Human Endometrial Stromal Cells were treated with non-toxic concentrations of copper ions (0-250 uM). mRNA expressions of insulin-like growth factor binding protein (IGFBP-1), prolactin (PRL), Mn-SOD, and FOXO1 were down-regulated during decidualization following the treatments with 100 or 250 uM copper ions. Meanwhile, the amount of malonaldehyde in the supernatant of cells was increased.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:51:06 GMT 2023
Edited
by admin
on Fri Dec 15 15:51:06 GMT 2023
Record UNII
S2QG84156O
Record Status Validated (UNII)
Record Version
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Name Type Language
CUPRIC CHLORIDE
INCI   ORANGE BOOK   USP   VANDF  
INCI  
Official Name English
COPPER (AS CUPRIC CHLORIDE) [VANDF]
Common Name English
CUPRIC CHLORIDE [VANDF]
Common Name English
COPPER CHLORIDE [VANDF]
Common Name English
Copper chloride dihydrate [WHO-DD]
Common Name English
CUPRIC CHLORIDE [INCI]
Common Name English
CUPRUM MURIATICUM
HPUS  
Common Name English
COPPER CHLORIDE DIHYDRATE
WHO-DD  
Systematic Name English
CUPRIC CHLORIDE DIHYDRATE
MI  
Common Name English
COPPER(II) CHLORIDE DIHYDRATE
Systematic Name English
CUPRIC CHLORIDE [USP MONOGRAPH]
Common Name English
CUPRIC CHLORIDE [ORANGE BOOK]
Common Name English
COPPER CHLORIDE (CUCL2) DIHYDRATE
Common Name English
CUPRUM MURIATICUM [HPUS]
Common Name English
KIRTICOPPER
Common Name English
COPPER(II)CHLORIDE DIHYDRATE
Systematic Name English
Copper(2+) chloride dihydrate
Systematic Name English
CUPRIC CHLORIDE [USP IMPURITY]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 23802
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
EPA PESTICIDE CODE 23701
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
NCI_THESAURUS C29730
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
Code System Code Type Description
ECHA (EC/EINECS)
215-704-5
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
ChEMBL
CHEMBL1200553
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
CAS
1344-67-8
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
ALTERNATIVE
DRUG CENTRAL
4530
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
CHEBI
86318
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
EPA CompTox
DTXSID1049564
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
MERCK INDEX
m3893
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY Merck Index
PUBCHEM
26342
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PRIMARY
CAS
10125-13-0
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
DAILYMED
S2QG84156O
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
NCI_THESAURUS
C61692
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
FDA UNII
S2QG84156O
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
CHEBI
49553
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
SMS_ID
100000091575
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
DRUG BANK
DB09131
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
EVMPD
SUB26837
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
RXCUI
21833
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY RxNorm
MESH
C029892
Created by admin on Fri Dec 15 15:51:06 GMT 2023 , Edited by admin on Fri Dec 15 15:51:06 GMT 2023
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE
PARENT -> SALT/SOLVATE
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ACTIVE MOIETY