Details
Stereochemistry | ACHIRAL |
Molecular Formula | 2Cl.Cu.2H2O |
Molecular Weight | 170.483 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.[Cl-].[Cl-].[Cu++]
InChI
InChIKey=MPTQRFCYZCXJFQ-UHFFFAOYSA-L
InChI=1S/2ClH.Cu.2H2O/h2*1H;;2*1H2/q;;+2;;/p-2
Molecular Formula | Cu |
Molecular Weight | 63.546 |
Charge | 2 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | HO |
Molecular Weight | 17.0073 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a84d61a4-8e7f-4be1-aba6-f633b334aafc | http://www.sciencedirect.com/science/article/pii/S0167488912000158http://www.drugfuture.com/chemdata/schweizer-s-reagent.html | http://pubs.acs.org/doi/abs/10.1021/ed062p878?journalCode=jceda8 | http://pubs.acs.org/doi/abs/10.1021/ed019p356http://www.emdmillipore.com/US/en/product/Copper-di-ammonium-Titriplex-solution,MDA_CHEM-105217https://www.ncbi.nlm.nih.gov/pubmed/15704330 | https://www.ncbi.nlm.nih.gov/pubmed/12425037 | https://www.ncbi.nlm.nih.gov/pubmed/1599240 | http://www.certisusa.com/pdf-labels/Kocide3000_label.pdf | http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33524https://www.ncbi.nlm.nih.gov/pubmed/8556785 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.518 | http://www.worldofchemicals.com/chemicals/chemical-properties/cupric-glycinate.htmlDOI: 10.1107/s0567740869001725 Retrived from http://scripts.iucr.org/cgi-bin/paper?S0567740869001725https://www.ncbi.nlm.nih.gov/pubmed/16971307https://www3.epa.gov/pesticides/chem_search/ppls/019713-00509-20110705.pdfhttp://www.drugfuture.com/chemdata/tetraamminecopper-sulfate.html | https://cameochemicals.noaa.gov/chemical/3026https://www.ncbi.nlm.nih.gov/pubmed/6526221http://fs1.agrian.com/pdfs/CORE_7.5_Copper_EDTA_Label.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/24106015 | https://www.ncbi.nlm.nih.gov/pubmed/20942456http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013010.pdfCurator's Comment: description was created based on several sources, including
https://www.copper.org/resources/properties/compounds/other_compounds.html | http://www.vitamins-supplements.org/dietary-minerals/copper.php | https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=bea888b4-9cc6-49da-89e6-5c273b974ed1
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a84d61a4-8e7f-4be1-aba6-f633b334aafc | http://www.sciencedirect.com/science/article/pii/S0167488912000158http://www.drugfuture.com/chemdata/schweizer-s-reagent.html | http://pubs.acs.org/doi/abs/10.1021/ed062p878?journalCode=jceda8 | http://pubs.acs.org/doi/abs/10.1021/ed019p356http://www.emdmillipore.com/US/en/product/Copper-di-ammonium-Titriplex-solution,MDA_CHEM-105217https://www.ncbi.nlm.nih.gov/pubmed/15704330 | https://www.ncbi.nlm.nih.gov/pubmed/12425037 | https://www.ncbi.nlm.nih.gov/pubmed/1599240 | http://www.certisusa.com/pdf-labels/Kocide3000_label.pdf | http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33524https://www.ncbi.nlm.nih.gov/pubmed/8556785 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.518 | http://www.worldofchemicals.com/chemicals/chemical-properties/cupric-glycinate.htmlDOI: 10.1107/s0567740869001725 Retrived from http://scripts.iucr.org/cgi-bin/paper?S0567740869001725https://www.ncbi.nlm.nih.gov/pubmed/16971307https://www3.epa.gov/pesticides/chem_search/ppls/019713-00509-20110705.pdfhttp://www.drugfuture.com/chemdata/tetraamminecopper-sulfate.html | https://cameochemicals.noaa.gov/chemical/3026https://www.ncbi.nlm.nih.gov/pubmed/6526221http://fs1.agrian.com/pdfs/CORE_7.5_Copper_EDTA_Label.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/24106015 | https://www.ncbi.nlm.nih.gov/pubmed/20942456http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013010.pdf
Curator's Comment: description was created based on several sources, including
https://www.copper.org/resources/properties/compounds/other_compounds.html | http://www.vitamins-supplements.org/dietary-minerals/copper.php | https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=bea888b4-9cc6-49da-89e6-5c273b974ed1
Cupric oxide is the oxide of the copper with the chemical formula of CuO. It is used in the ceramic industry for imparting blue, green or red tints in glasses, glazes and enamels. Cupric oxide is also used as a source for copper in food supplements. Copper is an essential nutrient and a normal constituent of the diet in man and animals. The average daily dietary requirement for copper in humans has been estimated at 0.03 mg/kg body weight. Although rare, copper deficiency has been induced by supplemental zinc therapy.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19014916https://www.ncbi.nlm.nih.gov/pubmed/27022258
Curator's Comment: Known to be CNS active in zebrafish. Human data not available.
Originator
Sources: Schweizer, J. Prakt. Chem. 72, 109, 344 (1857).http://pubs.acs.org/doi/abs/10.1021/ja01512a012
Curator's Comment: http://www.drugfuture.com/chemdata/schweizer-s-reagent.html
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL1075246 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3861140 |
3.42 µM [Ki] | ||
Target ID: P00450 Gene ID: 1356.0 Gene Symbol: CP Target Organism: Homo sapiens (Human) |
|||
Target ID: Glutathione S-transferase, rat, liver Sources: https://www.ncbi.nlm.nih.gov/pubmed/3008276 |
|||
Target ID: GO:0072593 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8503093 |
|||
Target ID: CHEMBL354 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22098250 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Preventing | Unknown Approved UseUnknown |
|||
Preventing | Unknown Approved UseUnknown |
|||
Preventing | Cupric glycinate Approved UseIndications for use. For beef calves and beef cattle for the prevention of copper deficiency, or when labeled for veterinary prescription use, for the prevention and/or treatment of copper deficiency alone or in association with molybdenum toxicity. |
|||
Primary | COPPER•MAX Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
|||
Preventing | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
|||
Diagnostic | Unknown Approved UseUnknown |
|||
Preventing | COPPER Approved UseCopper 0.4 mg/mL (Cupric Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain copper serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms. |
|||
Preventing | COPINOX Approved UseCopinox 4g is indicated for the prevention and treatment of copper deficiency in cattle and sheep. |
PubMed
Title | Date | PubMed |
---|---|---|
The effect of various fluoride compounds on the development of experimental root surface caries in hamsters. | 1995 Dec |
|
Copper Fluoride Luminescence during UV Photofragmentation of Bis(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)copper(II) in the Gas Phase. | 1996 Aug 14 |
|
The effectiveness of ecologically acceptable ways of protection of field-grown tomato (Lycopersicon lycopersicum (L.) Karsten) from tomato late blight (Phytophthora infestans (Mont.) de Bary) in extreme weather conditions. | 2001 |
|
Antioxidant activity of olive pulp and olive oil phenolic compounds of the arbequina cultivar. | 2005 Mar 23 |
|
Acute copper toxicity following copper glycinate injection. | 2006 Nov |
|
A spectroscopic and thermoanalytical study of the mineral hoganite. | 2007 May |
|
Bioavailability of copper from copper glycinate in steers fed high dietary sulfur and molybdenum. | 2008 Jan |
|
Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide. | 2008 Nov 1 |
|
Copper(II) acetate-catalyzed addition of arylboronic acids to aromatic aldehydes. | 2009 Jan 16 |
|
Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells. | 2009 Oct |
|
Insight in the transport behavior of copper glycinate complexes through the porcine gastrointestinal membrane using an Ussing chamber assisted by mass spectrometry analysis. | 2010 Apr |
|
A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy. | 2010 Nov 3 |
|
Protective effect of sulphoraphane against oxidative stress mediated toxicity induced by CuO nanoparticles in mouse embryonic fibroblasts BALB 3T3. | 2012 Feb |
|
Probing the chemical nature of dihydrogen complexation to transition metals, a gas phase case study: H2-CuF. | 2013 Jan 18 |
|
Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses. | 2013 Nov |
|
SILAC-based quantitative proteomic analysis of human lung cell response to copper oxide nanoparticles. | 2014 |
|
Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts. | 2014 |
|
Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells. | 2014 Jul |
|
Electron induced surface reactions of organometallic metal(hfac)₂ precursors and deposit purification. | 2014 Jun 11 |
|
Unusual 4-arsonoanilinium cationic species in the hydrochloride salt of (4-aminophenyl)arsonic acid and formed in the reaction of the acid with copper(II) sulfate, copper(II) chloride and cadmium chloride. | 2017 Apr 1 |
|
Supplementation with copper edetate in control of Haemonchus contortus of sheep, and its effect on cholinesterase's and superoxide dismutase activities. | 2017 Feb |
|
Comparison of the efficacy of a commercial footbath product with copper sulfate for the control of digital dermatitis. | 2017 Jul |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a84d61a4-8e7f-4be1-aba6-f633b334aafc
Curator's Comment: Veterinary drug
Copper 0.4 mg/mL (Cupric Chloride Injection) contains 0.4 mg copper/mL and is administered intravenously only after dilution. The additive should be diluted in a volume of fluid not less than 100 mL. For the adult receiving total parenteral nutrition, the suggested additive dosage is 0.5 to 1.5 mg copper/day (1.25 to 3.75 mL/day). For pediatric patients, the suggested additive dosage is 20 mcg copper/kg/day (0.05 mL/kg/day). Infants weighing less than 1500 gm may have increased requirements because of their low body reserves and increased requirements for growth.
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27726061
Human Endometrial Stromal Cells were treated with non-toxic concentrations of copper ions (0-250 uM). mRNA expressions of insulin-like growth factor binding protein (IGFBP-1), prolactin (PRL), Mn-SOD, and FOXO1 were down-regulated during decidualization following the treatments with 100 or 250 uM copper ions. Meanwhile, the amount of malonaldehyde in the supernatant of cells was increased.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 16 18:23:50 UTC 2022
by
admin
on
Fri Dec 16 18:23:50 UTC 2022
|
Record UNII |
S2QG84156O
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
EPA PESTICIDE CODE |
23802
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
||
|
EPA PESTICIDE CODE |
23701
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
||
|
NCI_THESAURUS |
C29730
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
215-704-5
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
CHEMBL1200553
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
1344-67-8
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
ALTERNATIVE | |||
|
4530
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
86318
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
DTXSID1049564
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
M3893
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | Merck Index | ||
|
26342
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
10125-13-0
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
S2QG84156O
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
C61692
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
S2QG84156O
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
49553
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
DB09131
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
SUB26837
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | |||
|
21833
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY | RxNorm | ||
|
C029892
Created by
admin on Fri Dec 16 18:23:51 UTC 2022 , Edited by admin on Fri Dec 16 18:23:51 UTC 2022
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ANHYDROUS->SOLVATE | |||
|
PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |