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Details

Stereochemistry ACHIRAL
Molecular Formula 2Cl.Cu.2H2O
Molecular Weight 170.483
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CUPRIC CHLORIDE

SMILES

O.O.[Cl-].[Cl-].[Cu++]

InChI

InChIKey=MPTQRFCYZCXJFQ-UHFFFAOYSA-L
InChI=1S/2ClH.Cu.2H2O/h2*1H;;2*1H2/q;;+2;;/p-2

HIDE SMILES / InChI

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Cu
Molecular Weight 63.546
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a84d61a4-8e7f-4be1-aba6-f633b334aafc | http://www.sciencedirect.com/science/article/pii/S0167488912000158https://www.ncbi.nlm.nih.gov/pubmed/15704330 | https://www.ncbi.nlm.nih.gov/pubmed/12425037 | https://www.ncbi.nlm.nih.gov/pubmed/1599240 | http://www.certisusa.com/pdf-labels/Kocide3000_label.pdf | http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33524https://www.ncbi.nlm.nih.gov/pubmed/24106015 | https://www.ncbi.nlm.nih.gov/pubmed/20942456http://fs1.agrian.com/pdfs/CORE_7.5_Copper_EDTA_Label.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/16971307https://www.ncbi.nlm.nih.gov/pubmed/8556785 | https://www.ncbi.nlm.nih.gov/pubmed/2135524https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.518 | http://www.worldofchemicals.com/chemicals/chemical-properties/cupric-glycinate.htmlhttps://www3.epa.gov/pesticides/chem_search/ppls/019713-00509-20110705.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/6526221http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013010.pdfhttp://www.emdmillipore.com/US/en/product/Copper-di-ammonium-Titriplex-solution,MDA_CHEM-105217http://www.drugfuture.com/chemdata/schweizer-s-reagent.html | http://pubs.acs.org/doi/abs/10.1021/ed062p878?journalCode=jceda8 | http://pubs.acs.org/doi/abs/10.1021/ed019p356DOI: 10.1107/s0567740869001725 Retrived from http://scripts.iucr.org/cgi-bin/paper?S0567740869001725http://www.drugfuture.com/chemdata/tetraamminecopper-sulfate.html | https://cameochemicals.noaa.gov/chemical/3026
Curator's Comment: description was created based on several sources, including https://www.copper.org/resources/properties/compounds/other_compounds.html | http://www.vitamins-supplements.org/dietary-minerals/copper.php | https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=bea888b4-9cc6-49da-89e6-5c273b974ed1

Tetraamminecopper sulfate is a dark blue crystalline solid with a faint odor of ammonia. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Used as a pesticide and fungicide, to print fabrics (especially in calico finishing), and to make other copper compounds.

CNS Activity

Curator's Comment: Known to be CNS active in zebrafish. Human data not available.

Originator

Sources: http://pubs.acs.org/doi/abs/10.1021/ja01512a012Schweizer, J. Prakt. Chem. 72, 109, 344 (1857).
Curator's Comment: http://www.drugfuture.com/chemdata/schweizer-s-reagent.html

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Preventing
Cupric glycinate

Approved Use

Indications for use. For beef calves and beef cattle for the prevention of copper deficiency, or when labeled for veterinary prescription use, for the prevention and/or treatment of copper deficiency alone or in association with molybdenum toxicity.
Primary
COPPER•MAX

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Diagnostic
Unknown

Approved Use

Unknown
Preventing
COPPER

Approved Use

Copper 0.4 mg/mL (Cupric Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain copper serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Preventing
COPINOX

Approved Use

Copinox 4g is indicated for the prevention and treatment of copper deficiency in cattle and sheep.
PubMed

PubMed

TitleDatePubMed
Determination of protein by the biuret reaction using cupric hydroxide suspension reagent.
1960
Efficacy of burning, tillage, and biocides in controlling bacteria released at field sites and effects on indigenous bacteria and fungi.
1992 Apr
The effectiveness of ecologically acceptable ways of protection of field-grown tomato (Lycopersicon lycopersicum (L.) Karsten) from tomato late blight (Phytophthora infestans (Mont.) de Bary) in extreme weather conditions.
2001
X-ray absorption spectroscopy study of a copper-containing material after thermal treatment.
2006 Apr 17
Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide.
2008 Nov 1
Molecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis.
2011 Dec 27
Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts.
2014
Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions.
2014
Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells.
2014 Jul
Comparison of the efficacy of a commercial footbath product with copper sulfate for the control of digital dermatitis.
2017 Jul
Patents

Sample Use Guides

In Vivo Use Guide
Copper 0.4 mg/mL (Cupric Chloride Injection) contains 0.4 mg copper/mL and is administered intravenously only after dilution. The additive should be diluted in a volume of fluid not less than 100 mL. For the adult receiving total parenteral nutrition, the suggested additive dosage is 0.5 to 1.5 mg copper/day (1.25 to 3.75 mL/day). For pediatric patients, the suggested additive dosage is 20 mcg copper/kg/day (0.05 mL/kg/day). Infants weighing less than 1500 gm may have increased requirements because of their low body reserves and increased requirements for growth.
Route of Administration: Intravenous
Human Endometrial Stromal Cells were treated with non-toxic concentrations of copper ions (0-250 uM). mRNA expressions of insulin-like growth factor binding protein (IGFBP-1), prolactin (PRL), Mn-SOD, and FOXO1 were down-regulated during decidualization following the treatments with 100 or 250 uM copper ions. Meanwhile, the amount of malonaldehyde in the supernatant of cells was increased.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:10:56 GMT 2025
Edited
by admin
on Mon Mar 31 18:10:56 GMT 2025
Record UNII
S2QG84156O
Record Status Validated (UNII)
Record Version
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Name Type Language
CUPRIC CHLORIDE DIHYDRATE
MI  
Preferred Name English
CUPRIC CHLORIDE
INCI   ORANGE BOOK   USP   VANDF  
INCI  
Official Name English
COPPER (AS CUPRIC CHLORIDE) [VANDF]
Common Name English
CUPRIC CHLORIDE [VANDF]
Common Name English
COPPER CHLORIDE [VANDF]
Common Name English
Copper chloride dihydrate [WHO-DD]
Common Name English
CUPRUM MURIATICUM
HPUS  
Common Name English
COPPER CHLORIDE DIHYDRATE
WHO-DD  
Systematic Name English
COPPER(II) CHLORIDE DIHYDRATE
Systematic Name English
CUPRIC CHLORIDE [USP MONOGRAPH]
Common Name English
CUPRIC CHLORIDE [ORANGE BOOK]
Common Name English
COPPER CHLORIDE (CUCL2) DIHYDRATE
Common Name English
CUPRUM MURIATICUM [HPUS]
Common Name English
KIRTICOPPER
Common Name English
COPPER(II)CHLORIDE DIHYDRATE
Systematic Name English
Copper(2+) chloride dihydrate
Systematic Name English
CUPRIC CHLORIDE [USP IMPURITY]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 23802
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
EPA PESTICIDE CODE 23701
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
NCI_THESAURUS C29730
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
Code System Code Type Description
ECHA (EC/EINECS)
215-704-5
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
ChEMBL
CHEMBL1200553
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
CAS
1344-67-8
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
ALTERNATIVE
DRUG CENTRAL
4530
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PRIMARY
CHEBI
86318
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
EPA CompTox
DTXSID1049564
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
MERCK INDEX
m3893
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY Merck Index
PUBCHEM
26342
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PRIMARY
CAS
10125-13-0
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
DAILYMED
S2QG84156O
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
NCI_THESAURUS
C61692
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
FDA UNII
S2QG84156O
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
CHEBI
49553
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
SMS_ID
100000091575
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
DRUG BANK
DB09131
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
EVMPD
SUB26837
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
RXCUI
21833
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY RxNorm
MESH
C029892
Created by admin on Mon Mar 31 18:10:56 GMT 2025 , Edited by admin on Mon Mar 31 18:10:56 GMT 2025
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY