U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 19:25:09 UTC 2023
Edited
by admin
on Thu Jul 06 19:25:09 UTC 2023
Protein Type SIGNAL TRANSDUCER
Protein Sub Type TRANSCRIPTION ACTIVATOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
51F8I2CLT3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
Common Name English
STAT3
Common Name English
ACUTE-PHASE RESPONSE FACTOR
Common Name English
APRF
Common Name English
Code System Code Type Description
FDA UNII
51F8I2CLT3
Created by admin on Thu Jul 06 19:25:10 UTC 2023 , Edited by admin on Thu Jul 06 19:25:10 UTC 2023
PRIMARY
UNIPROT
P40763
Created by admin on Thu Jul 06 19:25:10 UTC 2023 , Edited by admin on Thu Jul 06 19:25:10 UTC 2023
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
ACTIVATOR -> TARGET
INHIBITOR -> TARGET
In HepG2 cells, in the presence of 50 pM IL-6 (luciferase assay)
INHIBITOR
IC50
INHIBITOR OF EXPRESSION->TARGET
INHIBITOR -> TARGET
Inhibits phosphorylation, cell proliferation and induces apoptosis.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INDUCER -> TARGET
INHIBITOR OF EXPRESSION->TARGET
INHIBITOR -> TARGET
Inhibits the activation of STAT3 signaling resulting from tyrosine residue phosphorylation (Y705) leads to aberrant oncogene transcription.
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL