GOLOTIMOD

Possibly Marketed Outside US

First approved in 2020

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H19N3O5
Molecular Weight	333.3392
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@H](CCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O)C(O)=O

InChI

InChIKey=CATMPQFFVNKDEY-YPMHNXCESA-N

InChI=1S/C16H19N3O5/c17-11(15(21)22)5-6-14(20)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12/h1-4,8,11,13,18H,5-7,17H2,(H,19,20)(H,21,22)(H,23,24)/t11-,13+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C16H19N3O5
Molecular Weight	333.3392
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15246665 | https://www.drugbank.ca/drugs/DB05475 | https://www.ncbi.nlm.nih.gov/pubmed/16499289 | https://clinicaltrials.gov/ct2/show/NCT00968357 | https://clinicaltrials.gov/ct2/show/NCT00756951

Golotimod (SCV-07) is compound that has been investigated as a medicine for the treatment of tuberculosis, and various other viral and bacterial infections. Golotimod acts broadly on the Toll-like receptor (TLR) pathway. It stimulates the T-helper 1 (Th1) type immune response and blocks signal transducers and activator of transcription 3 (STAT3) mediated signaling. Treatment of tuberculosis with golotimod improves clearance of mycobacteria, cavity healing, and immune parameters and also reduced symptoms (such as fever, weakness, sweating, dry cough, productive cough, dyspnea, chest pain, tachycardia) without adverse effects. Phase II clinical trials have been completed to assess its safety and tolerability.

Approval Year

PubMed

Title	Date	PubMed
Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07).	2010-10	20412446
SCV-07 (SciClone Pharmaceuticals/Verta).	2006-02	16499289
Development of an efficient enzymatic production of gamma-D-glutamyl-L-tryptophan (SCV-07), a prospective medicine for tuberculosis, with bacterial gamma-glutamyltranspeptidase.	2004-08-05	15246665
Gateways to clinical trials.	2003-06	12851663
Immune system stimulator shows promise against tuberculosis.	2002-12	12467673

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:46:59 GMT 2025` Edited by `admin` on `Wed Apr 02 08:46:59 GMT 2025`
Record UNII	637C487Y09
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SCV-07

Preferred Name

English

GOLOTIMOD

Official Name

English

Golotimod [WHO-DD]

Common Name

English

golotimod [INN]

Common Name

English

D-.GAMMA.-GLUTAMYL-L-TRYPTOPHAN

Systematic Name

English

GOLOTIMOD [USAN]

Common Name

English

(2R)-2-Amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C129820