DANVATIRSEN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 07:05:09 GMT 2025` Edited by `admin` on `Wed Apr 02 07:05:09 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Type	COMPLETE
Record UNII	31N550RD05
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DANVATIRSEN

Official Name

English

AZD-9150

Preferred Name

English

ALL-P-AMBO-2'-O,4'-C-((1S)-ETHANE-1,1-DIYL)-5-METHYL-PTHIOCYTIDYLYL-(3'->5')-2'-O,4'-C-((1S)-ETHANE-1,1-DIYL)-5-METHYL-P-THIOURIDYLYL-(3'->5')-2'-O,4'-C-((1S)-ETHANE-1,1-DIYL)-P-THIOADENYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-PTHIOTHYMIDYLYL-(3'->5')-P-T

Common Name

English

danvatirsen [INN]

Common Name

English

ISIS-481464

Code

English

Danvatirsen [WHO-DD]

Common Name

English

ISIS-STAT3RX

Code

English

DANVATIRSEN [USAN]

Common Name

English

AZD9150

Code

English

ALL-P-AMBO-2'-O,4'-C-((1S)-ETHANE-1,1-DIYL)-5-METHYL-P-THIOCYTIDYLYL-(3'->5')-2'-O,4'-C-((1S)-ETHANE-1,1-DIYL)-5-METHYL-P-THIOURIDYLYL-(3'->5')-2'-O,4'-C-((1S)-2-ETHANE-1,1-DIYL)-P-THIOADENYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')

Systematic Name

English

DNA, D(P-THIO)(((5'.XI.)-2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)-.ALPHA.-L-LYXO-HEXOFURANO)M5C-(3'->4')-((5'.XI.)-2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)-.ALPHA.-L-LYXO-HEXOFURANO)M5U-(3'->4')-((5'.XI.)-2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1291

Created by admin on Wed Apr 02 07:05:09 GMT 2025 , Edited by admin on Wed Apr 02 07:05:09 GMT 2025

Code System Code Type Description

SMS_ID

100000175531

Created by admin on Wed Apr 02 07:05:09 GMT 2025 , Edited by admin on Wed Apr 02 07:05:09 GMT 2025

PRIMARY

CAS

1402357-06-5

Created by admin on Wed Apr 02 07:05:09 GMT 2025 , Edited by admin on Wed Apr 02 07:05:09 GMT 2025

PRIMARY

INN

10612

Created by admin on Wed Apr 02 07:05:09 GMT 2025 , Edited by admin on Wed Apr 02 07:05:09 GMT 2025

PRIMARY

FDA UNII

31N550RD05

Created by admin on Wed Apr 02 07:05:09 GMT 2025 , Edited by admin on Wed Apr 02 07:05:09 GMT 2025

PRIMARY

DRUG BANK

DB14825

Created by admin on Wed Apr 02 07:05:09 GMT 2025 , Edited by admin on Wed Apr 02 07:05:09 GMT 2025

PRIMARY

USAN

FG-83

Created by admin on Wed Apr 02 07:05:09 GMT 2025 , Edited by admin on Wed Apr 02 07:05:09 GMT 2025

PRIMARY

NCI_THESAURUS

C101368

Created by admin on Wed Apr 02 07:05:09 GMT 2025 , Edited by admin on Wed Apr 02 07:05:09 GMT 2025

PRIMARY

CAS

1402100-56-4

Created by admin on Wed Apr 02 07:05:09 GMT 2025 , Edited by admin on Wed Apr 02 07:05:09 GMT 2025

SUPERSEDED

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_4-1_13	10 / 16
2,'4'-locked-Ribose (alpha-L-LNA)	1_1-1_3;1_14-1_16	6 / 16

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_16	15 / 15

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					31N550RD05

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_1] [1_16]	SITE_SPECIFIC			5-METHYLDEOXYCYTIDINE	B200GV71QM