TTI-101

Investigational

COC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(O)C3=C2C=CC=C3)C4=C5C=CC=CC5=CC=C4O

InChIKey=QDCJDYWGYVPBDO-UHFFFAOYSA-N

InChI=1S/C27H21NO5S/c1-33-18-11-13-19(14-12-18)34(31,32)28-24-16-23(27(30)22-9-5-4-8-21(22)24)26-20-7-3-2-6-17(20)10-15-25(26)29/h2-16,28-30H,1H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Signal transducer and activator of transcription 3 10 Target ID: P40763 Gene ID: 6774.0 Gene Symbol: STAT3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21447830 \| https://www.ncbi.nlm.nih.gov/pubmed/25787076	Inhibitor 8297		136.0 nM [Ki]

PubMed

Title	Date	PubMed
Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor.	2011 May 26	21447830
Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia.	2015 Apr 24	25787076
C188-9, a small-molecule STAT3 inhibitor, exerts an antitumor effect on head and neck squamous cell carcinoma.	2019 Sep	30870229

Substance Class	Chemical Created by `admin` on `Sat Dec 16 13:40:00 UTC 2023` Edited by `admin` on `Sat Dec 16 13:40:00 UTC 2023`
Record UNII	KZ3DLD11RQ
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

TTI-101

Code

English

TTI101

Code

English

TTI 101 [WHO-DD]

Common Name

English

STAT3 INHIBITOR C188-9

Common Name

English

BENZENESULFONAMIDE, N-(1',2-DIHYDROXY(1,2'-BINAPHTHALEN)-4'-YL)-4-METHOXY-

Common Name

English

C-188-9

Code

English

STAT3 INHIBITOR TTI-101

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

866721