Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Wed Apr 02 02:41:21 GMT 2025
by
admin
on
Wed Apr 02 02:41:21 GMT 2025
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
4U7WR2K3GX
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
4U7WR2K3GX
Created by
admin on Wed Apr 02 02:41:21 GMT 2025 , Edited by admin on Wed Apr 02 02:41:21 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
AGONIST -> TARGET | |||
|
RADIOLIGAND->TARGET |
|
||
|
RADIOLIGAND->TARGET |
|
||
|
RADIOLIGAND->TARGET |
Also contains a low affinity binding site Ki ~200 nanomolar.
Ki
|
||
|
RADIOLIGAND->TARGET |
SSR180575 promotes neuronal survival and repair in axotomy and neuropathy models and have potential for the treatment of neurodegenerative diseases
IC50
|
||
|
LIGAND->TARGET |
BINDING
Ki
|
||
|
|
LIGAND->TARGET |
Enhances cholesterol transport into mitochondria leading to increase level of neurosteroid synthesis.
|
||
|
RADIOLIGAND->TARGET |
|
||
|
|
RADIOLIGAND->TARGET |
|
||
|
RADIOLIGAND->TARGET |
Susceptible to the rs6971 polymorphism, which affects the affinity of the radioligand binding to the TSPO and separates individuals into high-affinity binders (HABs), mixed-affinity binders (MABs), and low-affinity binders.
|
||
|
LIGAND->TARGET |
|
||
|
|
RADIOLIGAND->TARGET |
|
||
|
RADIOLIGAND->TARGET |
PET with radioligands targeting the TSPO can detect patterns of neuroinflammation in vivo. Monitoring activated microglia is of great interest to assess disease severity and progressionas well as therapeutic efficacy of anti-inflammatory drugs. Several recent lines of evidence support that neuroinflammation plays an important role in schizophrenia.
|
||
|
LIGAND->TARGET |
May affect the localization of TSPO moving it from the mitochondria to cytosol. Also contains a low affinity binding site Ki~200 nanomolar.
BINDING
Ki
|
||
|
AGONIST -> TARGET |
Ki
|
||
|
RADIOLIGAND->TARGET | |||
|
|
AGONIST -> TARGET |
|
||
|
|
RADIOLIGAND->TARGET |
|
||
|
RADIOLIGAND->TARGET |
|
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) | CHEMICAL |
|
||||
| Molecular Formula | CHEMICAL |
|