Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 14:59:50 UTC 2023
by
admin
on
Sat Dec 16 14:59:50 UTC 2023
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| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
4U7WR2K3GX
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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4U7WR2K3GX
Created by
admin on Sat Dec 16 14:59:52 UTC 2023 , Edited by admin on Sat Dec 16 14:59:52 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
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AGONIST -> TARGET | |||
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RADIOLIGAND->TARGET |
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RADIOLIGAND->TARGET |
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RADIOLIGAND->TARGET |
Also contains a low affinity binding site Ki ~200 nanomolar.
Ki
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RADIOLIGAND->TARGET |
SSR180575 promotes neuronal survival and repair in axotomy and neuropathy models and have potential for the treatment of neurodegenerative diseases
IC50
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LIGAND->TARGET |
BINDING
Ki
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LIGAND->TARGET |
Enhances cholesterol transport into mitochondria leading to increase level of neurosteroid synthesis.
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RADIOLIGAND->TARGET |
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RADIOLIGAND->TARGET |
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LIGAND->TARGET |
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RADIOLIGAND->TARGET |
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RADIOLIGAND->TARGET |
PET with radioligands targeting the TSPO can detect patterns of neuroinflammation in vivo. Monitoring activated microglia is of great interest to assess disease severity and progressionas well as therapeutic efficacy of anti-inflammatory drugs. Several recent lines of evidence support that neuroinflammation plays an important role in schizophrenia.
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LIGAND->TARGET |
May affect the localization of TSPO moving it from the mitochondria to cytosol. Also contains a low affinity binding site Ki~200 nanomolar.
BINDING
Ki
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RADIOLIGAND->TARGET |
Drugs: 18F FEMPA(Primary); Indications: Alzheimer's disease; Focus: Diagnostic use; Most Recent Event: 20 Nov 2014 New trial record
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AGONIST -> TARGET |
Ki
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AGONIST -> TARGET |
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RADIOLIGAND->TARGET |
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RADIOLIGAND->TARGET |
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) | CHEMICAL |
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| Molecular Formula | CHEMICAL |
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