TRANSLOCATOR PROTEIN

Approval Year

Substance Class	Protein
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	4U7WR2K3GX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MITOCHONDRIAL BENZODIAZEPINE RECEPTOR

Preferred Name

English

TRANSLOCATOR PROTEIN

Common Name

English

PKBS

Common Name

English

TRANSLOCATOR PROTEIN (HUMAN)

Common Name

English

TSPO

Common Name

English

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Code System

Code

Type

Description

FDA UNII

4U7WR2K3GX

PRIMARY

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Subunit 0

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Related Record

Type

Details


					C68RF62SNJ

FGIN-143

AGONIST -> TARGET


					M3708K4Z4V

DPA-713 C-11

RADIOLIGAND->TARGET

Amount:


					0VMV8Z3972

DPA-714 F-18

RADIOLIGAND->TARGET

Amount:


					82MI0GT75Z

PBR-28 C-11

RADIOLIGAND->TARGET

Comments:

Also contains a low affinity binding site Ki ~200 nanomolar.

Qualification:

Ki

Amount:

4 NANOMOLAR (average)


					N8CG9437DN

SSR-180575 C-11

RADIOLIGAND->TARGET

Comments:

SSR180575 promotes neuronal survival and repair in axotomy and neuropathy models and have potential for the treatment of neurodegenerative diseases

Qualification:

IC50

Amount:

[2.5 to 3.5] NANOMOLAR (average)

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL	NUMBER AVERAGE 18000 DA (average)
Molecular Formula	CHEMICAL	ESTIMATED C891H1290N223O213S5

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