Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H20N2O3 |
| Molecular Weight | 348.3951 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(CN(C(C)=O)C2=C(OC3=CC=CC=C3)C=CN=C2)C=CC=C1
InChI
InChIKey=DHZBNHMEIOBPAE-UHFFFAOYSA-N
InChI=1S/C21H20N2O3/c1-16(24)23(15-17-8-6-7-11-20(17)25-2)19-14-22-13-12-21(19)26-18-9-4-3-5-10-18/h3-14H,15H2,1-2H3
| Molecular Formula | C21H20N2O3 |
| Molecular Weight | 348.3951 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
PBR28 or PBR-28, a chemical substance that binds to translocator protein TSPO, also known as Peripheral-type benzodiazepine receptor (PBR). TSPO located within the cells such as macrophages reaches high levels of expression in inflammatory conditions and thus can be a biomarker of neuroinflammation. When radioactivity in the form of carbon-11 is tagged to PBR 28 and is administered, its uptake in the inflammatory body regions can be measured using positron emission tomography (PET). PBR28 now is involved in a clinical trial to evaluate the specificity of its binding in the joints of patients with inflammatory joint disease, like rheumatoid and psoriatic arthritis.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation. | 2007 Dec |
|
| Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors. | 2008 Feb 1 |
|
| Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28. | 2015 |
|
| Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET. | 2016 Aug 31 |
|
| Tracking Macrophage Infiltration in a Mouse Model of Pancreatic Cancer with the Positron Emission Tomography Tracer [11C]PBR28. | 2018 Dec |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 20:10:21 UTC 2023
by
admin
on
Sat Dec 16 20:10:21 UTC 2023
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| Record UNII |
4XS5FDP2HY
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| Record Status |
Validated (UNII)
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| Record Version |
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9841240
Created by
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253307-65-2
Created by
admin on Sat Dec 16 20:10:21 UTC 2023 , Edited by admin on Sat Dec 16 20:10:21 UTC 2023
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4XS5FDP2HY
Created by
admin on Sat Dec 16 20:10:21 UTC 2023 , Edited by admin on Sat Dec 16 20:10:21 UTC 2023
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| Related Record | Type | Details | ||
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TARGET->LIGAND |
May affect the localization of TSPO moving it from the mitochondria to cytosol. Also contains a low affinity binding site Ki~200 nanomolar.
BINDING
Ki
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LABELED -> NON-LABELED |
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