Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H20N2O3 |
| Molecular Weight | 347.3958 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)N(CC1=C(O[11CH3])C=CC=C1)C2=C(OC3=CC=CC=C3)C=CN=C2
InChI
InChIKey=DHZBNHMEIOBPAE-JVVVGQRLSA-N
InChI=1S/C21H20N2O3/c1-16(24)23(15-17-8-6-7-11-20(17)25-2)19-14-22-13-12-21(19)26-18-9-4-3-5-10-18/h3-14H,15H2,1-2H3/i2-1
| Molecular Formula | C21H20N2O3 |
| Molecular Weight | 347.3958 |
| Charge | 0 |
| Count |
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| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:48:57 GMT 2023
by
admin
on
Sat Dec 16 11:48:57 GMT 2023
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| Record UNII |
82MI0GT75Z
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| Record Status |
Validated (UNII)
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| Record Version |
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922528-31-2
Created by
admin on Sat Dec 16 11:48:58 GMT 2023 , Edited by admin on Sat Dec 16 11:48:58 GMT 2023
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1005325-43-8
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admin on Sat Dec 16 11:48:58 GMT 2023 , Edited by admin on Sat Dec 16 11:48:58 GMT 2023
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11653141
Created by
admin on Sat Dec 16 11:48:58 GMT 2023 , Edited by admin on Sat Dec 16 11:48:58 GMT 2023
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82MI0GT75Z
Created by
admin on Sat Dec 16 11:48:58 GMT 2023 , Edited by admin on Sat Dec 16 11:48:58 GMT 2023
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C121962
Created by
admin on Sat Dec 16 11:48:58 GMT 2023 , Edited by admin on Sat Dec 16 11:48:58 GMT 2023
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NON-LABELED -> LABELED |
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NON-LABELED -> LABELED |
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TARGET->RADIOLIGAND |
Also contains a low affinity binding site Ki ~200 nanomolar.
Ki
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ACTIVE MOIETY |
We also calculated the area under the time-activity curve from 0 to 120 minutes to compare specific organ uptake of (11C)-(R)-PK 11195 to that reported using (11C)PBR28. Using (11C)-(R)-PK 11195, pre-blockade with nonradioactive PBR28 decreased the area under the curve by only 31%, 14%, and 30% in lung, brain, and kidney, respectively. Using (11C)PBR28, pharmacological blockade was previously reported to decreased the area under the curve by 70%, 42%, and 50% in lung, brain, and kidney, respectively (Imaizumi et al., 2008). Whole body imaging with the 11C-labeled radioligands showed that (11C)PBR28 detects non-binding in all five target organs with high densities of TSPO (lung, heart, brain, kidney, and spleen).
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