PBR-111 F-18

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H25ClFN3O2
Molecular Weight	416.907
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)C(=O)CC1=C(N=C2C=CC(Cl)=CN12)C3=CC=C(OCCC[18F])C=C3

InChI

InChIKey=YFXIZOLPHFYYMF-MIGPCILRSA-N

InChI=1S/C22H25ClFN3O2/c1-3-26(4-2)21(28)14-19-22(25-20-11-8-17(23)15-27(19)20)16-6-9-18(10-7-16)29-13-5-12-24/h6-11,15H,3-5,12-14H2,1-2H3/i24-1

HIDE SMILES / InChI

Molecular Formula	C22H25ClFN3O2
Molecular Weight	416.907
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:54:09 GMT 2025` Edited by `admin` on `Mon Mar 31 22:54:09 GMT 2025`
Record UNII	3W97GXI2IU
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

J3.034.964D

Preferred Name

English

PBR-111 F-18

Common Name

English

[18F]PBR 111

Code

English

2-(6-CHLORO-2-(4-(3-(18F)FLUOROPROPOXY)PHENYL)IMIDAZO(1,2-A)PYRIDIN-3-YL)-N,N-DIETHYLACETAMIDE

Systematic Name

English

IMIDAZO(1,2-A)PYRIDINE-3-ACETAMIDE, 6-CHLORO-N,N-DIETHYL-2-(4-(3-(FLUORO-18F)PROPOXY)PHENYL)-

Systematic Name

English

[18F]PBR-111

Code

English

N,N-DIETHYL-(2-(4-(3-(18F)FLUOROPROPOXY)PHENYL)-6-CHLOROIMIDAZO(1,2-A)PYRIDINE-3-YL)ACETAMIDE

Systematic Name

English

[18F]-PBR111

Code

English

Code System Code Type Description

CAS

1009080-75-4

Created by admin on Mon Mar 31 22:54:09 GMT 2025 , Edited by admin on Mon Mar 31 22:54:09 GMT 2025

PRIMARY

PUBCHEM

24944913

Created by admin on Mon Mar 31 22:54:09 GMT 2025 , Edited by admin on Mon Mar 31 22:54:09 GMT 2025

PRIMARY

FDA UNII

3W97GXI2IU

Created by admin on Mon Mar 31 22:54:09 GMT 2025 , Edited by admin on Mon Mar 31 22:54:09 GMT 2025

PRIMARY

Related Record Type Details


					4U7WR2K3GX

TRANSLOCATOR PROTEIN

TARGET->RADIOLIGAND

Comments:

PET with radioligands targeting the TSPO can detect patterns of neuroinflammation in vivo. Monitoring activated microglia is of great interest to assess disease severity and progressionas well as therapeutic efficacy of anti-inflammatory drugs. Several recent lines of evidence support that neuroinflammation plays an important role in schizophrenia.

Amount:

Related Record Type Details


					3W97GXI2IU

PBR-111 F-18

ACTIVE MOIETY

Amount: