Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C21H29N7O14P2 |
Molecular Weight | 665.441 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 8 / 8 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)N4C=NC5=C4N=CN=C5N)[C@@H](O)[C@H]2O
InChI
InChIKey=BOPGDPNILDQYTO-NNYOXOHSSA-N
InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
Molecular Formula | C21H29N7O14P2 |
Molecular Weight | 665.441 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 8 / 8 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Nicotinamide adenine nucleotide (NAD) is a cofactor found in all living cells. It exists in oxidized form (NAD+) and reduced form (NADH). NADH is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). NADH supplements are used for improving mental clarity, alertness, concentration, and memory; as well as for treating Alzheimer’s disease and dementia. Because of its role in energy production, NADH is also used for improving athletic performance and treating chronic fatigue syndrome (CFS). Some people use NADH for treating high blood pressure, high cholesterol, jet lag, depression, and Parkinson’s disease; opposing alcohol’s effects on the liver; reducing signs of aging; protecting against the side effects of an AIDS drug called zidovudine (AZT).
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL4506 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21528845 |
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Target ID: CHEMBL4835 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8308865 |
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Target ID: CHEMBL1970 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8308865 |
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PubMed
Title | Date | PubMed |
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Structure of lactate dehydrogenase inhibitor generated from coenzyme. | 1979 Apr 3 |
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Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase. | 1992 Apr 25 |
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RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria. | 1993 Feb |
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Trichomonas hydrogenosomes contain the NADH dehydrogenase module of mitochondrial complex I. | 2004 Dec 2 |
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Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance. | 2004 Oct 26 |
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Biomimetics with a self-assembled monolayer of catalytically active tethered isoalloxazine on Au. | 2005 Aug 16 |
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Canal wall reconstruction and mastoid obliteration with composite multi-fractured osteoperiosteal flap. | 2006 Dec |
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NADPH- diaphorase positive cardiac neurons in the atria of mice. A morphoquantitative study. | 2006 Feb 2 |
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High-resolution intravital NADH fluorescence microscopy allows measurements of tissue bioenergetics in rat ileal mucosa. | 2006 Jan |
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Superoxide anion is elevated in sympathetic neurons in DOCA-salt hypertension via activation of NADPH oxidase. | 2006 Mar |
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Effect of water activity on inactivation of Listeria monocytogenes and lactate dehydrogenase during high pressure processing. | 2008 May 10 |
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Structural and mechanistic roles of three consecutive Pro residues of porcine NADH-cytochrome b(5) reductase for the binding of beta-NADH. | 2009 Oct |
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Structural and redox behavior of OxyVita, a zero-linked polymeric hemoglobin: comparison with natural acellular polymeric hemoglobins. | 2010 Apr |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:56:42 GMT 2023
by
admin
on
Sat Dec 16 01:56:42 GMT 2023
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Record UNII |
4J24DQ0916
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Record Status |
Validated (UNII)
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DSLD |
2235 (Number of products:5)
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DTXSID30889320
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4J24DQ0916
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16908
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57945
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439153
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NADH
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7222
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200-393-0
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m7699
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SUB33719
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100000127643
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DB00157
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58-68-4
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4J24DQ0916
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
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ACTIVE MOIETY |