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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H27N7O14P2.2Na
Molecular Weight 709.4046
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DISODIUM NICOTINAMIDE ADENINE DINUCLEOTIDE

SMILES

[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)N4C=NC5=C4N=CN=C5N)[C@@H](O)[C@H]2O

InChI

InChIKey=QRGNQKGQENGQSE-WUEGHLCSSA-L
InChI=1S/C21H29N7O14P2.2Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;/q;2*+1/p-2/t10-,11-,13-,14-,15-,16-,20-,21-;;/m1../s1

HIDE SMILES / InChI
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C21H27N7O14P2
Molecular Weight 663.4251
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 8 / 8
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Nicotinamide adenine nucleotide (NAD) is a cofactor found in all living cells. It exists in oxidized form (NAD+) and reduced form (NADH). NADH is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). NADH supplements are used for improving mental clarity, alertness, concentration, and memory; as well as for treating Alzheimer’s disease and dementia. Because of its role in energy production, NADH is also used for improving athletic performance and treating chronic fatigue syndrome (CFS). Some people use NADH for treating high blood pressure, high cholesterol, jet lag, depression, and Parkinson’s disease; opposing alcohol’s effects on the liver; reducing signs of aging; protecting against the side effects of an AIDS drug called zidovudine (AZT).

Approval Year

2011
587
Targets

Targets

Primary TargetPharmacologyConditionPotency
Substrate
661
Substrate
661
Substrate
661
Modulator
828
PubMed

PubMed

TitleDatePubMed
Structure of lactate dehydrogenase inhibitor generated from coenzyme.
1979 Apr 3
RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria.
1993 Feb
Role of redox potential of hemoglobin-based oxygen carriers on methemoglobin reduction by plasma components.
2002 Jan
Mitochondrial NADH redox state, monitoring discovery and deployment in tissue.
2004
High-resolution intravital NADH fluorescence microscopy allows measurements of tissue bioenergetics in rat ileal mucosa.
2006 Jan
Superoxide anion is elevated in sympathetic neurons in DOCA-salt hypertension via activation of NADPH oxidase.
2006 Mar
Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.
2007 May
Patents

Patents

JP1005500A
2
JP1018057A
2
JP1043197A
2
JP1045374A
2
JP1047386A
2
JP2000007696A
2
JP2000060563A
2
JP2000069971A
2
JP2000078969A
2
JP2000139499A
3
JP2000189188A
3
JP2000224991A
2
JP2000236883A
2
JP2000245478A
2
JP2000300292A
2
JP2000502262A
2
JP2001037499A
2
JP2001061472A
2
JP2001061498A
2
JP2001204493A
2
JP2001218579A
5
JP2001258595A
2
JP2002095499A
2
JP2002223788A
2
JP2002233395A
2
JP2002345479A
2
JP2003057235A
2
JP2003116585A
2
JP2003135057A
2
JP2003169697A
2
JP2003319788A
2
JP2003334069A
2
JP2004002446A
2
JP2004024088A
2
JP2004024140A
2
JP2004049028A
2
JP2004049138A
2
JP2004065078A
2
JP2004113040A
2
JP2004233289A
2
JP2004283120A
2
JP2004305016A
2
JP2004321114A
4
JP2004344107A
2
JP2005034044A
2
JP2005053783A
2
JP2005087149A
2
JP2005124401A
2
JP2005185145A
2
JP2005278432A
2
JP2005515451A
2
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:14:03 GMT 2023
Edited
by admin
on Fri Dec 15 15:14:03 GMT 2023
Record UNII
8295030YNC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DISODIUM NICOTINAMIDE ADENINE DINUCLEOTIDE
Common Name English
DISODIUM NADH [INCI]
Common Name English
NICOTINAMIDE ADENINE DINUCLEOTIDE DISODIUM REDUCED
Common Name English
DISODIUM NICOTINAMIDE ADENINE DINUCLEOTIDE REDUCED
Common Name English
NICOTINAMIDE ADENINE DINUCLEOTIDE DISODIUM
Common Name English
.BETA.-NICOTINAMIDE ADENINE DINUCLEOTIDE DISODIUM SALT
Common Name English
NADH DISODIUM SALT
Common Name English
DISODIUM NADH
INCI  
INCI  
Official Name English
Code System Code Type Description
CAS
606-68-8
Created by admin on Fri Dec 15 15:14:03 GMT 2023 , Edited by admin on Fri Dec 15 15:14:03 GMT 2023
PRIMARY
ECHA (EC/EINECS)
210-123-3
Created by admin on Fri Dec 15 15:14:03 GMT 2023 , Edited by admin on Fri Dec 15 15:14:03 GMT 2023
PRIMARY
FDA UNII
8295030YNC
Created by admin on Fri Dec 15 15:14:03 GMT 2023 , Edited by admin on Fri Dec 15 15:14:03 GMT 2023
PRIMARY
PUBCHEM
2724710
Created by admin on Fri Dec 15 15:14:03 GMT 2023 , Edited by admin on Fri Dec 15 15:14:03 GMT 2023
PRIMARY
RXCUI
1716102
Created by admin on Fri Dec 15 15:14:03 GMT 2023 , Edited by admin on Fri Dec 15 15:14:03 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID901014657
Created by admin on Fri Dec 15 15:14:03 GMT 2023 , Edited by admin on Fri Dec 15 15:14:03 GMT 2023
PRIMARY
DAILYMED
8295030YNC
Created by admin on Fri Dec 15 15:14:03 GMT 2023 , Edited by admin on Fri Dec 15 15:14:03 GMT 2023
PRIMARY
Related Record Type Details
Structure of NADH
PARENT -> SALT/SOLVATE
NIH
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