| Stereochemistry | RACEMIC |
| Molecular Formula | C19H26Cl2N2O |
| Molecular Weight | 369.329 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 1 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN([C@H]1CCCC[C@H]1N2CCCC2)C(=O)CC3=CC=C(Cl)C(Cl)=C3
InChI
InChIKey=VQLPLYSROCPWFF-QRWMCTBCSA-N
InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17?,18-/m1/s1
| Molecular Formula | C19H26Cl2N2O |
| Molecular Weight | 369.329 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
CNS Activity
Originator
Approval Year
PubMed
Patents
Sample Use Guides
C57BL6 male mice were placed in the open field for 30 min prior to injection of vehicle (saline) or 5 mg/kg i.p. U50488 (Tocris). Two hours later, mice were transcardially perfused with 4% paraformaldehyde (PFA) and 0.1 M PBS. Brains were postfixed overnight in PBS with 4% PFA and then transferred to 20% sucrose in PBS with 4% PFA.
Route of Administration:
Intraperitoneal
Flasks of T. brucei were seeded at 1 x 104 cells/ml and incubated in the presence of the U50,488 for 3 days. Flasks were set up in triplicate for each inhibitor at multiples of EC50 along with 3 control flasks with no inhibitor added. Pentamidine and U50,488 were added in DMSO in a volume of 0.1% of the culture. Eflornithine was dissolved directly in HMI9-T medium and sterilised by 0.22 mMfiltration before diluting into the cell culture.
