DescriptionCurator's Comment: description was created based on several sources, including:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5176be07-3121-49fb-9eb9-638903753a31 | https://www.drugs.com/monograph/atracurium-besylate.html | http://www.wikidoc.org/index.php/Atracurium
Curator's Comment: description was created based on several sources, including:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5176be07-3121-49fb-9eb9-638903753a31 | https://www.drugs.com/monograph/atracurium-besylate.html | http://www.wikidoc.org/index.php/Atracurium
Atracurium is an intermediate-duration, nondepolarizing, skeletal muscle relaxant for intravenous administration. It is used, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Most adverse reactions were suggestive of histamine release. Common side effects include flushing of the skin and low blood pressure. Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine.
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2362997 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19417616 |
169.5 nM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Palliative | ATRACURIUM BESYLATE Approved UseAtracurium Besylate Injection, USP is indicated, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Launch Date8.6918398E11 |
PubMed
Title | Date | PubMed |
---|---|---|
Synthesis and structure-activity relationships of neuromuscular blocking agents. | 2002 Aug |
|
[Establishment of a hypothermic dog model to investigate airway rewarming]. | 2006 Aug |
|
Dynamic encoding of natural luminance sequences by LGN bursts. | 2006 Jul |
|
Anaesthetic management of post-burn contractures, a recurrent challenge from oil pipeline vandalization in Nigeria: a case report. | 2009 Dec 3 |
|
Leaking abdominal aortic aneurysm on anticoagulants-thromboelastography assisted management. | 2009 Jun |
|
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
|
Comparison between Culture Conditions Improving Growth and Differentiation of Blood and Bone Marrow Cells Committed to the Endothelial Cell Lineage. | 2010 Feb 6 |
|
Cisatracurium in different doses versus atracurium during general anesthesia for abdominal surgery. | 2010 Sep |
Patents
Sample Use Guides
An atracurium besylate dose of 0.4 to 0.5 mg/kg (1.7 to 2.2 times the ED95), given as an intravenous bolus injection, is the recommended initial dose for most patients. Maximum neuromuscular block achieved approximately 3 to 5 minutes after injection.
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2720863
Exposure of isolated rat hepatocytes to atracurium produced cellular damage evidenced by extrusion of an intracellular enzyme, lactate dehydrogenase (LDH), into the incubation medium. Leakage of LDH was directly related to the concentration of atracurium in the medium (250 to 800 microM). When atracurium was added to the medium and the medium immediately added to hepatocytes, the leakage of LDH increased as the concentration of atracurium increased (P < 0.001 for the comparison with cells not exposed to atracurium).
Substance Class |
Mixture
Created
by
admin
on
Edited
Fri Dec 16 20:00:19 UTC 2022
by
admin
on
Fri Dec 16 20:00:19 UTC 2022
|
Record UNII |
2GQ1IRY63P
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NDF-RT |
N0000175720
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
||
|
WHO-ESSENTIAL MEDICINES LIST |
20
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
||
|
WHO-VATC |
QM03AC04
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
||
|
NCI_THESAURUS |
C66886
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
||
|
WHO-ATC |
M03AC04
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
||
|
NDF-RT |
N0000175732
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
2GQ1IRY63P
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY | |||
|
D001279
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY | |||
|
2914
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY | |||
|
C76068
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY | |||
|
Atracurium
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY | |||
|
SUB00618MIG
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY | |||
|
DTXSID9043726
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY | |||
|
64228-79-1
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY | |||
|
259
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY | |||
|
2GQ1IRY63P
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY | |||
|
DB00732
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY | |||
|
1218
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY | RxNorm | ||
|
ATRACURIUM
Created by
admin on Fri Dec 16 20:00:19 UTC 2022 , Edited by admin on Fri Dec 16 20:00:19 UTC 2022
|
PRIMARY |
All of the following components must be present:
Related Record | Type | Details | ||
---|---|---|---|---|
|
SALT/SOLVATE -> PARENT | |||
|
BINDER->LIGAND |
BINDING
|
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
---|---|---|---|---|---|---|
Volume of Distribution | PHARMACOKINETIC |
|
|
|||
Biological Half-life | PHARMACOKINETIC |
|
|
|||