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Description
Curator's Comment: description was created based on several sources, including: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5176be07-3121-49fb-9eb9-638903753a31 | https://www.drugs.com/monograph/atracurium-besylate.html | http://www.wikidoc.org/index.php/Atracurium

Atracurium is an intermediate-duration, nondepolarizing, skeletal muscle relaxant for intravenous administration. It is used, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Most adverse reactions were suggestive of histamine release. Common side effects include flushing of the skin and low blood pressure. Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
169.5 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
ATRACURIUM BESYLATE

Approved Use

Atracurium Besylate Injection, USP is indicated, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Launch Date

1997
PubMed

PubMed

TitleDatePubMed
Synthesis and structure-activity relationships of neuromuscular blocking agents.
2002 Aug
[Relaxation and the electromyographic identification of the recurrent laryngeal nerve].
2002 Sep
[Interaction of donepezil and muscular blockers in Alzheimer's disease].
2003 Feb
[Establishment of a hypothermic dog model to investigate airway rewarming].
2006 Aug
Donepezil in Alzheimer's disease: From conventional trials to pharmacogenetics.
2007 Jun
Modulation of temporal precision in thalamic population responses to natural visual stimuli.
2010
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Comparison between Culture Conditions Improving Growth and Differentiation of Blood and Bone Marrow Cells Committed to the Endothelial Cell Lineage.
2010 Feb 6
Marfan syndrome with acute abdomen: a case report.
2010 Nov 10
Cisatracurium in different doses versus atracurium during general anesthesia for abdominal surgery.
2010 Sep
Patents

Sample Use Guides

An atracurium besylate dose of 0.4 to 0.5 mg/kg (1.7 to 2.2 times the ED95), given as an intravenous bolus injection, is the recommended initial dose for most patients. Maximum neuromuscular block achieved approximately 3 to 5 minutes after injection.
Route of Administration: Intravenous
In Vitro Use Guide
Exposure of isolated rat hepatocytes to atracurium produced cellular damage evidenced by extrusion of an intracellular enzyme, lactate dehydrogenase (LDH), into the incubation medium. Leakage of LDH was directly related to the concentration of atracurium in the medium (250 to 800 microM). When atracurium was added to the medium and the medium immediately added to hepatocytes, the leakage of LDH increased as the concentration of atracurium increased (P < 0.001 for the comparison with cells not exposed to atracurium).
Substance Class Mixture
Created
by admin
on Fri Dec 15 16:08:13 GMT 2023
Edited
by admin
on Fri Dec 15 16:08:13 GMT 2023
Record UNII
40AX66P76P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ATRACURIUM BESYLATE
MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF  
USAN  
Official Name English
ISOQUINOLINIUM, 2,2'-(1,5-PENTANEDIYLBIS(OXY(3-OXO-3,1-PROPANEDIYL)))BIS(1-((3,4-DIMETHOXYPHENYL)METHYL)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL-, (1R,2R,1'R,2'R)- BISBENZENESULFONATE
Common Name English
NSC-760047
Code English
(1R,2R,1'R,2'R)-2,2'-(PENTANE-1,5-DIYLBIS(OXY(3-OXOPROPANE-3,1-DIYL)))BIS(1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINIUM) BISBENZENESULFONATE
Common Name English
ATRACURIUM BESYLATE [MI]
Common Name English
ATRACURIUM BESILATE
EP   INN   MART.   WHO-DD  
INN  
Official Name English
ATRACURIUM BESYLATE [USAN]
Common Name English
TRACRIUM
Brand Name English
ATRACURIUM BESYLATE [VANDF]
Common Name English
ATRACURIUM BESYLATE [USP-RS]
Common Name English
atracurium besilate [INN]
Common Name English
2-(2-Carboxyethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium benzenesulfonate, pentamethylene ester
Common Name English
BW-33A
Code English
ATRACURIUM DIBESYLATE
Common Name English
WELLCOME 33-A-74
Code English
ATRACURIUM BESYLATE [ORANGE BOOK]
Common Name English
BW 33A
Code English
ATRACURIUM BESILATE [MART.]
Common Name English
Atracurium besilate [WHO-DD]
Common Name English
ATRACURIUM BESYLATE [USP MONOGRAPH]
Common Name English
ATRACURIUM BESILATE [EP MONOGRAPH]
Common Name English
ISOQUINOLINIUM, 2,2'-(1,5-PENTANEDIYLBIS(OXY(3-OXO-3,1-PROPANEDIYL)))BIS(1-((3,4-DIMETHOXYPHENYL)METHYL)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL-, DIBENZENESULFONATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29696
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
Code System Code Type Description
INN
4734
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
EVMPD
SUB05603MIG
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
ECHA (EC/EINECS)
264-743-4
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PRIMARY
DRUG BANK
DB00732
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
RXCUI
1219
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PRIMARY RxNorm
NCI_THESAURUS
C28839
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PRIMARY
ChEMBL
CHEMBL1360
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PRIMARY
NSC
760047
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PRIMARY
EPA CompTox
DTXSID6022630
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PRIMARY
CAS
64228-81-5
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PRIMARY
MERCK INDEX
m2129
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PRIMARY Merck Index
FDA UNII
40AX66P76P
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
WIKIPEDIA
ATRACURIUM BESILATE
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
RS_ITEM_NUM
1044800
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
CHEBI
2915
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PRIMARY
USAN
T-90
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PRIMARY
DAILYMED
40AX66P76P
Created by admin on Fri Dec 15 16:08:13 GMT 2023 , Edited by admin on Fri Dec 15 16:08:13 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY
Definition References