| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H12O4 |
| Molecular Weight | 268.2641 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(C=C1)C2=COC3=C(C=CC(O)=C3)C2=O
InChI
InChIKey=HKQYGTCOTHHOMP-UHFFFAOYSA-N
InChI=1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3
| Molecular Formula | C16H12O4 |
| Molecular Weight | 268.2641 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Formononetin, an isoflavone, derived from Astragalus membranaceus, possesses the potential to reduce obesity and associated metabolic disorders. Formononetin displays estrogenic properties and induces angiogenesis activities. It regulates adipocyte thermogenesis as a partial PPARγ agonist and produces proangiogenesis effects through estrogen receptor alpha (ERα)-enhanced ROCK-II signaling pathways, by direct binding to the ligand-binding domain (LBD) of ERα. Besides, was shown, that formononetin inhibits HMGB1 release by decreasing HMGB1 acetylation via upregulating SIRT1 in a PPARδ-dependent manner and the identification of this process may help to treat inflammation-related disorders.
Approval Year
Sample Use Guides
The mice were fed on a high fat diet (D12492, Research Diets) for 8 weeks to become obese, and then randomly divided into two groups and gavaged for the following 8 weeks with either Astragalus membranaceus water extract (3.3g/kg) or formononetin (50mg/kg) and vehicle (control) on a high fat diet.
Route of Administration:
Oral
Showing 1 to 5 of 6 entries