U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 10:25:02 GMT 2023
Edited
by admin
on Sat Dec 16 10:25:02 GMT 2023
Source Materials Class ORGANISM
Source Materials Type PLANT
Source Materials Parent
Part RHIZOME; ROOT; STOLON
Record UNII
42B5YD8F0K
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
GLYCYRRHIZA URALENSIS
Preferred Name English
GLYCYRRHIZA URALENSIS ROOT
WHO-DD  
Common Name English
GANCAO (GLYCYRRHIZA URALENSIS)
Common Name English
LOLOZ WITH CAVIBLOC
Brand Name English
Glycyrrhiza uralensis root [WHO-DD]
Common Name English
LIQUORICE ROOT (GLYCYRRHIZA URALENSIS)
Common Name English
GLYCYRRHIZAE RADIX ET RHIZOMA (GLYCYRRHIZA URALENSIS)
CHP  
Common Name English
PHY-906 COMPONENT GLYCYRRHIZA URALENSIS ROOT
Common Name English
URAL LICORICE ROOT
Common Name English
GLYCYRRHIZAE RADIX ET RHIZOMA (GLYCYRRHIZA URALENSIS) [CHP]
Common Name English
WU LA GAN CAO ROOT
Common Name English
GLYCYRRHIZA URALENSIS ROOT WITH RHIZOME
WHO-DD  
Common Name English
Glycyrrhiza uralensis root with rhizome [WHO-DD]
Common Name English
CHINESE HERBAL FORMULATION PHY906 COMPONENT GLYCYRRHIZA URALENSIS ROOT
Common Name English
GLYCYRRHIZA (GLYCYRRHIZA URALENSIS) [JP]
Common Name English
YIV-906 COMPONENT GLYCYRRHIZA URALENSIS ROOT
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C79664
Created by admin on Sat Dec 16 10:25:09 GMT 2023 , Edited by admin on Sat Dec 16 10:25:09 GMT 2023
DSLD 3014 (Number of products:192)
Created by admin on Sat Dec 16 10:25:09 GMT 2023 , Edited by admin on Sat Dec 16 10:25:09 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C80296
Created by admin on Sat Dec 16 10:25:09 GMT 2023 , Edited by admin on Sat Dec 16 10:25:09 GMT 2023
PRIMARY
EVMPD
SUB130189
Created by admin on Sat Dec 16 10:25:09 GMT 2023 , Edited by admin on Sat Dec 16 10:25:09 GMT 2023
PRIMARY
RXCUI
1342493
Created by admin on Sat Dec 16 10:25:09 GMT 2023 , Edited by admin on Sat Dec 16 10:25:09 GMT 2023
PRIMARY RxNorm
FDA UNII
42B5YD8F0K
Created by admin on Sat Dec 16 10:25:09 GMT 2023 , Edited by admin on Sat Dec 16 10:25:09 GMT 2023
PRIMARY
DAILYMED
42B5YD8F0K
Created by admin on Sat Dec 16 10:25:09 GMT 2023 , Edited by admin on Sat Dec 16 10:25:09 GMT 2023
PRIMARY
EVMPD
SUB33295
Created by admin on Sat Dec 16 10:25:09 GMT 2023 , Edited by admin on Sat Dec 16 10:25:09 GMT 2023
PRIMARY
Related Record Type Details
CONSTITUENT ALWAYS PRESENT -> PARENT
ISOLICOFLAVONOL showed antibacterial activity against MSSAs (strains FDA 209P and Smith) and MRSAs(strains K3 and ST 28) (MICs1.56?25 ug/ml). This compound exhibited antimicrobial activity against Micrococcus luteus ATCC 9341 and Bacillus subtilis PCI 219 (MICs3.13?25 ug/ml) but not against Klebsiella pneumoniae PCI 602 and Pseudomonas aeruginosa IFO 3445.
CONSTITUENT ALWAYS PRESENT -> PARENT
ISOTRIFOLIOL was shown through anticoagulative assay to have significant antithrombotic activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
7,4'-dihydroxyflavone was tested for antithrombotic activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
The compound did not show significant cytotoxicity against uninfected MDCK cells at 100 uM, but showed inhibitory activity against the H1N1 virus at 100 uM. The compound was also evaluated for anti-HIV activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
Anti-H1N1 (IC50 in uM) activity of compound was shown to be 42.7 uM. The compound did not show significant cytotoxicity against uninfected MDCK cells at 100 uM, but showed inhibitory activity against the H1N1 virus at 100 uM. The compound was also evaluated for anti-HIV activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
The compound did not show significant cytotoxicity against uninfected MDCK cells at 100 uM, but showed inhibitory activity against the H1N1 virus at 100 uM. The compound was also evaluated for anti-HIV activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
LIQUIRITIN was tested for antimicrobial activity against methicillin sensitive Staphylococcus aureus, methicillin resistant S. aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa and found to be inactive.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
Anti-H1N1 (IC50 in uM) activity of compound was shown to be 49.1 uM. Anti-HIV (IC50 in uM) activity of compound was shown to be 29.5 uM. The compound did not show significant cytotoxicity against uninfected MDCK cells at 100 uM, but showed inhibitory activity against the H1N1 virus at 100 uM. The compound was also evaluated for anti-HIV activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
isoliquiritigenin was tested for antithrombotic activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
Anti-H1N1 (IC50 in uM) activity of compound was shown to be 39.6 uM. The compound did not show significant cytotoxicity against uninfected MDCK cells at 100 uM, but showed inhibitory activity against the H1N1 virus at 100 uM. The compound was also evaluated for anti-HIV activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
The compound did not show significant cytotoxicity against uninfected MDCK cells at 100 uM, but showed inhibitory activity against the H1N1 virus at 100 uM. The compound was also evaluated for anti-HIV activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
FORMONONETIN was tested for antimicrobial activity against methicillin sensitive Staphylococcus aureus, methicillin resistant S. aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa and found to be inactive.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
The compound did not show significant cytotoxicity against uninfected MDCK cells at 100 uM, but showed inhibitory activity against the H1N1 virus at 100 uM. The compound was also evaluated for anti-HIV activity.
ACTIVE CONSTITUENT ALWAYS PRESENT -> PARENT
The compound showed strong ferric reducing activities and effectively scavenged DPPH, ABTS+, and singlet oxygen radicals.
CONSTITUENT ALWAYS PRESENT -> PARENT
The compound did not show significant cytotoxicity against uninfected MDCK cells at 100 uM, but showed inhibitory activity against the H1N1 virus at 100 uM. The compound was also evaluated for anti-HIV activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
The compound did not show significant cytotoxicity against uninfected MDCK cells at 100 uM, but showed inhibitory activity against the H1N1 virus at 100 uM. The compound was also evaluated for anti-HIV activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
LIQUIRITIGENIN was tested for antithrombotic activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
GANCAONOL B was tested for antimicrobial activity against methicillin sensitive Staphylococcus aureus, methicillin resistant S. aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa and found to be inactive.
SUB_CONCEPT->SUBSTANCE
CONSTITUENT ALWAYS PRESENT -> PARENT
Structure elucidation of compound.
CONSTITUENT ALWAYS PRESENT -> PARENT
NEOGLYCYROL was tested for antithrombotic activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
LICOISOFLAVONE B showed 12.5 ug/ml MIC against methicillin-resistant Staphylococcus aureus and not determined for all others.
CONSTITUENT ALWAYS PRESENT -> PARENT
ISOGLYCYROL was tested for antimicrobial activity against methicillin sensitive Staphylococcus aureus, methicillin resistant S. aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa and found to be inactive.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
The compound did not show significant cytotoxicity against uninfected MDCK cells at 100 uM, but showed inhibitory activity against the H1N1 virus at 100 uM. The compound was also evaluated for anti-HIV activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
3-O-methylglycyrol showed a MIC of >16 ug/ml for antimicrobial activities against methicillin sensitive Staphylococcus aureus, methicillin resistant S. aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
Structure elucidation of compound.
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
CONSTITUENT ALWAYS PRESENT -> PARENT
JARANOL was tested for antithrombotic activity.
CONSTITUENT ALWAYS PRESENT -> PARENT
Anti-H1N1 (IC50 in uM) activity of compound was shown to be 48.0 uM. The compound did not show significant cytotoxicity against uninfected MDCK cells at 100 uM, but showed inhibitory activity against the H1N1 virus at 100 uM. The compound was also evaluated for anti-HIV activity.
CONSTITUENT ALWAYS PRESENT -> PARENT