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Development Status

Investigational

2

Other

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Primary Target

GABA-A receptor; anion channel

2

Glycogen synthase kinase-3 beta

2

Heat shock protein HSP90

2

Serine/threonine-protein kinase Aurora-B

2

Signal transducer and activator of transcription 3

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Highest Phase

Phase II

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Approval Year

Unknown

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Condition

Autism spectrum disorder

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Cancer

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Obesity

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Treatment Modality

Primary

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CNS Activity

CNS Active

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Originator

Chevreul, M.E.

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Chemical

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CAS

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PUBCHEM

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CHEBI

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Salts, Hydrates, Esters, etc.

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Showing 1 - 3 of 3 results

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LUTEOLIN MONOHYDRATE

N79TPJ3DTD

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Heat shock protein HSP90

GABA-A receptor; anion channel

Signal transducer and activator of transcription 3

Glycogen synthase kinase-3 beta

Serine/threonine-protein kinase Aurora-B

Conditions:

Autism spectrum disorder

Luteolin, 3',4',5,7-tetrahydroxyflavone, is a common flavonoid that exists in many types of plants including fruits, vegetables, and medicinal herbs. Plants rich in luteolin have been used in Chinese traditional medicine for treating various diseases...

such as hypertension, inflammatory disorders, and cancer. Luteolin possesses a variety of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial and anticancer activities. Numerous studies have shown that luteolin possesses beneficial neuroprotective effects both in vitro and in vivo.

FORMONONETIN

295DQC67BJ

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Estrogen receptor

Peroxisome proliferator-activated receptor gamma

Conditions:

Formononetin, an isoflavone, derived from Astragalus membranaceus, possesses the potential to reduce obesity and associated metabolic disorders. Formononetin displays estrogenic properties and induces angiogenesis activities. It regulates adipocyte t...

hermogenesis as a partial PPARγ agonist and produces proangiogenesis effects through estrogen receptor alpha (ERα)-enhanced ROCK-II signaling pathways, by direct binding to the ligand-binding domain (LBD) of ERα. Besides, was shown, that formononetin inhibits HMGB1 release by decreasing HMGB1 acetylation via upregulating SIRT1 in a PPARδ-dependent manner and the identification of this process may help to treat inflammation-related disorders.

LUTEOLIN

KUX1ZNC9J2

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Search for Structure

Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Heat shock protein HSP90

GABA-A receptor; anion channel

Signal transducer and activator of transcription 3

Glycogen synthase kinase-3 beta

Serine/threonine-protein kinase Aurora-B

Conditions:

Autism spectrum disorder

Luteolin, 3',4',5,7-tetrahydroxyflavone, is a common flavonoid that exists in many types of plants including fruits, vegetables, and medicinal herbs. Plants rich in luteolin have been used in Chinese traditional medicine for treating various diseases...

such as hypertension, inflammatory disorders, and cancer. Luteolin possesses a variety of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial and anticancer activities. Numerous studies have shown that luteolin possesses beneficial neuroprotective effects both in vitro and in vivo.

HHS VULNERABILITY DISCLOSURE

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